Aleukemic "leukemia cutis" of monocytic lineage

Gil-Mateo, M. P.; Miquel, F.J.; Piris, Miguel Á.; Sánchez, María Dolores Martín; Martín-Aragonés, G

doi:10.1016/s0190-9622(97)70035-5

Cited by 32 publications

(24 citation statements)

References 13 publications

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“…Radiotherapy may also be employed if necessary. Our findings and those reported in previous studies [3–9,11,12] showed that there is no effective treatment for this disease. Lee et al [22] employed sorafeni in the treatment of skin infiltration of AML with internal tandem duplication, and complete remission was observed.…”

Section: Discussioncontrasting

confidence: 47%

“…[3–9,11,12] This may be explained as that tumor cells in the skin escape from the killing of chemotherapeutics because most chemotherapeutics mainly kill tumor cells in the bone marrow, tumor cells in the skin are hard to be killed, and these tumor cells may be a major cause of recurrence. [1,20] Thus, some clinicians proposed that total skin electron beam radiation therapy may be employed simultaneously with chemotherapy in leukemia patients with skin involvement.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous presentation preceding acute monocytic leukemia

Jin

Li²,

Li³

et al. 2017

Medicine

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Rationale:Cutaneous presentation preceding acute myeloid leukemia (AML) is rare, and the prognosis is poor.Patient concerns:We report 4 cases of AML cutis, where skin infiltration precedes any blood or bone marrow evidence of leukemia. We also reviewed 13 cases reported in English and Chinese literature. The 4 cases all presented typical cutaneous lesions without any systemic evidence of leukemia. Histopathological examination found that dense monomorphous cell infiltration involved the dermis. Some cells surrounded blood vessels and skin appendages in a concentric manner or showed single-row arrangement in the collagen fiber bundles. Uninvolved papillary dermis was found to separate normal epidermis from dermal infiltration. Minor cells had a large kidney-shaped or oval nucleus with nucleoli and slightly eosinophilic cytoplasm. Immunohistochemical analysis was positive for CD4, CD56, while CD123 was negative in all cases.Diagnoses:AML-M5.Interventions:2 patients received chemotherapy ,but others rejected treatment.Outcomes:Most patients died within 1 year after the onset of skin lesions.Lessons:These findings suggest that skin infiltration of AML may precede any systemic evidence, and typical cutaneous lesions in elderly individuals may be indicative for AML.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Cutaneous presentation preceding acute monocytic leukemia

Jin

Li²,

Li³

et al. 2017

Medicine

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“…The prognosis of ALC associated with monocytic leukemia is poor. Eighteen [2, 4, 6, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]cases have been reported in the English literature as ALC associated with monocytic leukemia in which the white blood cell count was within normal limits and blast cells were not evident in the presence of eruptions. Some were misdiagnosed as cutaneous lymphoma and subsequently developed overt leukemia; others were diagnosed as leukemia and were treated with chemotherapy but failed to remit.…”

Section: Discussionmentioning

confidence: 99%

Acute Monocytic Leukemia Presenting as Cutaneous Involvement

Nakano¹,

Kusakabe²,

Kiyokane³

1999

Dermatology

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Specific cutaneous lesions appearing during acute monocytic leukemia (AMoL) are more frequent than those associated with other types of leukemia. However, skin involvement preceding the presence of leukemic cells in the peripheral blood is quite rare. In this paper, we describe a case where a 25-year-old male had multiple infiltrative erythemas and nodules on his arms. Histologically, the nodules were formed by masses of tumor cells in the dermis. Peripheral-blood tests revealed no abnormalities, but bone marrow aspiration from the sternum led to a diagnosis of AMoL. The diagnosis of specific cutaneous lesions of AMoL was confirmed by the results of cytochemical studies of bone marrow smears, and cutaneous nodules of cutaneous biopsy specimens led to early diagnosis. Complete remission was achieved with combination chemotherapy and peripheral blood stem cell transplantation.

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“…1 However, LC has also been described in association with chronic myelogenous leukemia, myelodysplastic syndromes (MDS), and acute lymphoblastic leukemias (T-ALL and B-ALL). [6][7][8] Rarely, cutaneous involvement by a leukemic infiltrate can occur in the absence of bone marrow or peripheral blood involvement by acute leukemia; this then is referred to as aleukemic LC (ALC) [9][10][11][12][13][14][15][16][17] or aleukemic myeloid sarcoma. Myeloid sarcoma, extramedullary myeloid tumor, granulocytic sarcoma, and monocytic sarcoma are often termed LC when occurring in the skin.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Aleukemic Leukemia Cutis

Gru

Coughlin

Schapiro

et al. 2015

The American Journal of Dermatopathology

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Leukemia cutis (LC) denotes a cutaneous infiltration of neoplastic myeloid cells or lymphoid blasts, which can present in the setting of acute myeloid leukemia, particularly in those cases with monocytic or myelomonocytic differentiation. Rarely, cutaneous involvement by a leukemic infiltrate can occur in the absence of bone marrow or peripheral blood involvement by acute leukemia; this then is referred to as aleukemic LC (ALC). Recognition of LC is important for further classification and early diagnosis of the disease, but the diagnosis is difficult in the absence of a systemic presentation of acute leukemia. Although the molecular and cytogenetic features of ALC are poorly characterized, some have shown specific molecular alterations in common with classic forms of acute leukemias. We present 3 cases of ALC in pediatric patients.

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Aleukemic "leukemia cutis" of monocytic lineage

Cited by 32 publications

References 13 publications

Cutaneous presentation preceding acute monocytic leukemia

Cutaneous presentation preceding acute monocytic leukemia

Acute Monocytic Leukemia Presenting as Cutaneous Involvement

Pediatric Aleukemic Leukemia Cutis

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