Aleukemic cutaneous myeloid sarcoma

Aboutalebi, Amir; Korman, John B.; Sohani, Aliyah R.; Hasserjian, Robert P.; Louissaint, Abner; Le, Long P.; Kraft, Stefan; Duncan, Lyn M.; Nazarian, Rosalynn M.

doi:10.1111/cup.12231

Cited by 28 publications

(45 citation statements)

References 43 publications

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“…Myeloid sarcoma is classified into four subtypes according to the various cell types involved, as follows: i) Granulocytic sarcoma; ii) primitive monocytic sarcoma; iii) myeloid sarcoma of hematopoietic cells; and iv) primary myeloid sarcoma without the presentation of other hematological diseases (1,2).…”

Section: Discussionmentioning

confidence: 99%

“…Myeloid sarcoma is a form of solid tumor, and is composed of immature white blood cells known as myeloblasts (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…The disease is classified into four groups according to tumor cell type, namely granulocytic sarcoma, primitive monocytic sarcoma, myeloid sarcoma of hematopoietic cell and primary myeloid sarcoma without the presentation of other hematological diseases (1,2). Myeloid sarcoma may develop at any age, but occurs most commonly in children and young individuals (3).…”

Section: Introductionmentioning

confidence: 99%

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The progression of CD56+ myeloid sarcoma: A case report and literature review

Wang

Zheng

et al. 2016

Oncology Letters

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Abstract.The current study presents a case of cluster of differentiation (CD)56 + myeloid sarcoma in a patient that initially presented with skin lesions, and provides evidence for the clinical and differential diagnosis of myeloid sarcoma. The patient of the present case report was a 65-year-old man who was admitted to hospital with a six-month history of bilateral purple-red papules and nodules, which were present on the upper limbs of the patient and had spread over his whole body one month prior to admission to the hospital. Pathological examination demonstrated a diffuse infusion of primitive round cells at the papillary dermis and subcutaneous tissues. The infiltrated cells were 40-60 µm in diameter and morphologically identical. Immunohistochemical examination revealed that the cells expressed myeloperoxidase, CD56, CD43 and T-cell intracytoplasmic antigen. In addition, several cells expressed CD34, and 90% of the cells expressed Ki67. While the majority of cells in myeloid sarcoma do not express CD56, the present case was a myeloid sarcoma that expressed CD56, which is extremely rare. The sarcoma in the present patient progressed rapidly, and the patient died eight months following the onset of disease. Clinicians should be aware of CD56 + myeloid sarcoma, which is easily misdiagnosed and inappropriately treated. Consequently, myeloid sarcoma may have a high malignancy and poor outcome for patients.

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Section: Discussionmentioning

confidence: 99%

“…Myeloid sarcoma is a form of solid tumor, and is composed of immature white blood cells known as myeloblasts (1,2).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The progression of CD56+ myeloid sarcoma: A case report and literature review

Wang

Zheng

et al. 2016

Oncology Letters

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“…AML can present with nonspecific cutaneous lesions or wounds or with more specific reactive cutaneous manifestations such as Sweet syndrome, erythema multiforme, and herpes infection, among others. 30 AML associated with t(6;9)(p23;q34)/DEK-NUP214 is included in the WHO classification category of AML with recurrent genetic abnormalities. These neoplasms represent 1% to 2% of all cases of AML, patients often have cytopenias, and these neoplasms are commonly associated with multilineage dysplasia, FLT3-ITD mutations, and a poor prognosis.…”

Section: Are There Extramedullary Manifestations Of Aml That Are Not mentioning

confidence: 99%

Extramedullary Manifestations of Myeloid Neoplasms

Wilson

Medeiros

2015

American Journal of Clinical Pathology

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“…Транслокация t(8;21) (q22;q22) встречается чаще при МС детского возраста. Методом полимеразной цепной реакции (ПЦР) опре-деляется химерный транскрипт FLT3-ITD [10].…”

Section: Introductionunclassified