Alendronic acid‐induced oral mucosal ulceration: two case reports

Abstract

Alendronic acid is generally a well-tolerated medication, however, there are well-established adverse effects known within dentistry, such as medication-related osteonecrosis of the jaw and upper gastro-intestinal disturbances, particularly erosive oesophagitis. There is growing evidence Case 1An 84-year-old female patient attended the emergency dental department, having been referred from her General Dental Practitioner complaining of

Oral bisphosphonates: Adverse effects on the oral mucosa not related to the jaw bones. A scoping review

“…After reading the full text, another 16 articles were excluded. Finally, 26 studies were included in this scoping review 26,27,32‐59 (Figure 1).…”

“…In three cases, the age of the patient was not mentioned 27,51 . Ten cases involved patients who were residents of a nursing facility or were receiving 24‐hour help at home 43,44,50,54‐56,59 …”

“…One case reported a patient with Down Syndrome, 41 whilst another case involved a legally blind patient suffering from schizophrenia 43 . One case involved a patient with congenital deafness 52 and another case was a non‐verbal patient with learning difficulties 59 . Cerebral palsy, 43 hemiplegia, 43 severe postural instability 52 and a thoracic compression fracture 42,56 were described in five individual cases.…”

“…27,51 Ten cases involved patients who were residents of a nursing facility or were receiving 24-hour help at home. 43,44,50,[54][55][56]59 The major indication for prescribing bisphosphonates was osteoporosis (51/56). In one case, the bisphosphonate was administrated because osteopenia, a preosteoporotic condition.…”

“…Most of the cases involved patients who used oral bisphosphonates in the form of tablets, except for one case where the alendronate tablets had been recently replaced by a drinkable solution of alendronate. 59 Forty-six patients used only alendronate (46/56), and one patient used alendronate in combination with etidronate and calcium. 43…”