Bisphosphonates are anti-resorptive agents highly efficient in binding bone hydroxyapatite. They can modulate the bone turnover and increase its mineral density. 1,2 Bisphosphonates are widely used to treat postmenopausal and corticosteroid-induced osteoporosis. 3 The use of bisphosphonates in osteoporosis has been shown to improve bone strength and decreases the risk of fracture. 4 Moreover, bisphosphonates are used in Paget's disease and fibrous dysplasia, 5 to balance metastatic cancer (primarily breast and prostate) deposits in bone, 6,7 to cure severe hypercalcemia 8 and to treat the bone resorption defects of multiple myeloma. 8 Some examples of widely used oral bisphosphonates are alendronate, risedronate, etidronate,