Alendronato de sódio: metodologias para análise quantitativa

Ribeiro, Ana Ferreira; Volpato, Nádia Maria

doi:10.1590/s0100-40422005000500024

Cited by 8 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analysis of bisphosphonates in biological samples presents challenges in both sample purification and analyte detection. Several review papers on the analysis of bisphosphonates have been published 4–6. Typical methods for sample purification involved the co‐precipitation of the bisphosphonates with calcium phosphate7, 8 and solid‐phase anion‐exchange extraction with strong acid9 or strong base10 as the elution solvent.…”

mentioning

confidence: 99%

A general approach for the quantitative analysis of bisphosphonates in human serum and urine by high‐performance liquid chromatography/tandem mass spectrometry

Zhu¹,

Lapko²,

Lee³

et al. 2006

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Bisphosphonates are extremely hydrophilic and structurally similar to many endogenous phosphorylated compounds, making their selective extraction from serum or urine very challenging. Many bisphosphonates lack strong chromophores for sensitive UV or fluorescence detection. We report here the first general approach to enable sensitive and selective quantitation of N-containing bisphosphonates by liquid chromatography/tandem mass spectrometry (LC/MS/MS) following derivatization with diazomethane. The novelty of the strategy lies in performing the derivatization on silica-based anion-exchange sorbents as an integrated step in the sample purification by solid-phase extraction (SPE). The 'on-cartridge' reaction with diazomethane not only led to higher efficiency of derivatization, but also enabled a more discriminatory recovery of the drug's derivatives. The derivatized bisphosphonates demonstrated improved chromatographic separation and increased sensitivity of the detection. The general applicability of the approach was demonstrated by validation of bioanalytical methods for risedronate and alendronate in human serum and urine. Sensitivity was achieved at the pg/mL level with merely 100-200 microL of sample.

show abstract

mentioning

confidence: 99%

A general approach for the quantitative analysis of bisphosphonates in human serum and urine by high‐performance liquid chromatography/tandem mass spectrometry

Zhu¹,

Lapko²,

Lee³

et al. 2006

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

“…23 Thus, there is a need to carefully follow the recommendations for use, since its bioavailability can reach zero if not correctly administered, generating complications of the clinical state, hospitalizations, fractures, and expenditures for the health system. 17,24,25 Therefore, most of the participants of the present study (69.3%) do not use the medication rationally, compromising its effectiveness and safety. Another Brazilian study shows a similar frequency of irrational use of alendronate sodium (68%), 19 but the present study differs when evaluating the use of the medication in the morning, a time that is more convenient and easy for fasting and to remain in an upright position until the next meal, thus avoiding the risk of gastroesophageal injury.…”

Section: Discussionmentioning

confidence: 81%

Irrational use of alendronate sodium by the elderly

Alvim

Figueiredo

Sousa

et al. 2020

Rev Bras Med Fam Comunidade

View full text Add to dashboard Cite

Introduction: The effectiveness and safety of alendronate sodium are dependent on patient adherence to very specific guidelines regarding use. This study aims to estimate the rational use of alendronate sodium in the elderly. Methods: This is a cross-sectional study carried out with a structured questionnaire containing form of use and occurrence of adverse events related to alendronate sodium. The patients were recruited in their own homes. Rational use was considered as being the participants who: a) took the tablet in the morning; b) were fasting; c) waited at least 30 minutes before eating; d) ingested with a full glass of water; e) ingested the whole tablet; f) and remained in the orthostatic position for at least 30 minutes after use. Additionally, the odds ratio (OR) was used to analyze the association between the irrational use of alendronate sodium and the independent variables. Results and Discussion: Of the 248 participants in the study, most of the participants administered the medication in the morning (95.2%), with fasting (89.1%), waited at least 30 minutes to eat the first meal of the day (87.9%), and were in the orthostatic position until the time of the first meal (78.6%), but less than half ingested the tablet with a full glass of water (43.6%). Rational use of the medication was observed in only 30.7% of the participants. Regarding possible adverse events, 13.3% of the participants reported some event. Among the most prevalent were dry cough (6.5%), stomach pain (5.2%) and some throat discomfort (4.8%). The irrational use of this medication is associated with age and education level. Conclusion: The prevalence of irrational use of alendronate sodium in the elderly is high, and this use is associated with patients’ sociodemographic factors.

show abstract

“…Em O método titulométrico empregado no ensaio de doseamento apresenta boa relação custo-benefício e é adequado para análise do fármaco em questão, porém, não distingue substâncias com propriedades físico-químicas semelhantes ou de mesmo grupo reacional, dessa forma há casos em que a especificidade não pode ser considerada. 17 O doseamento das diferentes apresentações comerciais de dipirona obedeceu 10.18606/2318-1419/amazonia.sci.health.v4n4p3-11 Revista Amazônia Science & Health. 2016 Out/Dez Costa TMF, Lopes JC.…”

Section: Resultsunclassified

Controle de Qualidade de Soluções Orais de Dipirona Sódica 500 mg/mL Referência, Genérico e Similar Comercializadas em Gurupi-TO

Lopes¹,

Costa²

2016

Amazônia Science & Health

View full text Add to dashboard Cite

Introduction:Dipyrone is widely used in Brazil, which makes it relevant to assess its quality in its various formulations, to ensure the efficacy and safety. Objective: Tests were conducted to verify the quality of dipyrone sodium oral solution 500mg/mL in reference, generic and similar presentations marketed in Gurupi-Tocantins-Brazil. Material and Methods: Lots of five different brands of dipyrone oral solution were evaluated, being the reference drug (Ref), two generic (Gen1 and Gen2) and two similar (Sim1 and Sim2), at a concentration of 500 mg/mL. The analysis of the information printed on the labels and in package leaflet was based on the current resolutions. The physical-chemical tests were conducted in accordance with official pharmacopeia compendium. Results: Some differences in the content and form of the information to users in all samples were found, Sim2 totaled the highest number of mismatches (seven), followed by the Gen1 (five), Sim1 (three), Gen2 (two) and Ref (one). The results of physical-chemical tests remained within the acceptable limits, except the drip test, in which the Ref and Sim2 were outside the specified minimum threshold. Conclusion: The results of the information printed were not satisfactory, presenting differences in the format of the information available.The physical-chemical tests were satisfactory, with the exception of the drip test for Ref and Sim2 drugs.

show abstract

Alendronato de sódio: metodologias para análise quantitativa

Cited by 8 publications

References 22 publications

A general approach for the quantitative analysis of bisphosphonates in human serum and urine by high‐performance liquid chromatography/tandem mass spectrometry

A general approach for the quantitative analysis of bisphosphonates in human serum and urine by high‐performance liquid chromatography/tandem mass spectrometry

Irrational use of alendronate sodium by the elderly

Controle de Qualidade de Soluções Orais de Dipirona Sódica 500 mg/mL Referência, Genérico e Similar Comercializadas em Gurupi-TO

Contact Info

Product

Resources

About