Alendronate Treatment to Prevent Osteoporotic Fractures

Abstract

Alendronate sodium, an aminobisphosphonate, has been approved by the Food and Drug Administration for the prevention and treatment of osteoporosis in postmenopausal women, thus providing an effective alternative to estrogen replacement therapy in women who cannot or will not take estrogen. Large, randomized, controlled trials have demonstrated approximately a 50% reduction in vertebral, hip, and wrist fractures. Efficacy and safety beyond 3 years has not been determined. To avoid esophagitis and maximize absorption, alendronate should be taken with 180 to 240 mL of water on arising for the day, allowing at least 30 minutes before the first food, beverage, or oral medication of the day is ingested.

Osteoporosis management among residents living in long-term care

“…A unique observation that is particularly concerning is that 10% of residents were taking a bisphosphonate but were not taking vitamin D or a multivitamin. Alterations in calcium and phosphorus metabolism can occur with bisphosphonate use, so supplemental calcium and vitamin D are recommended [35].…”

Dynamic expression of SMAD3 is critical in�osteoblast differentiation of PDMCs

“…To determine gene expression levels, total RNA was extracted from cells at each experimental time point using TRIzol ® reagent (Thermo Fisher Scientific, Inc., Waltham, MA, USA). Total RNA (1 µg) was reverse-transcribed using oligo (dT) 20 primer and SuperScript III First-Strand Synthesis System (Invitrogen; Thermo Fisher Scientific, Inc.) according to the manufacturer's protocol. The relative mRNA level of the target gene was quantified using qPCR with a TaqMan �robe and TaqMan Master Mix in a LightCycler Nano instrument (both Roche Diagnostics GmbH, Mannheim, Germany), according to the �anufacturer's �rotocol.…”

“…Clinically, osteoporotic fractures result in notable mortality and morbidity (18). Alendronate acid, a bisphosphonate, is the primary agent used to prevent and treat osteoporosis (20)(21)(22). Pharmacokinetic studies have indicated that ~50% of the alendronate absorbed into the body binds to bone surface, while the other 50% is rapidly excreted from the kidneys (20,23,24).…”

“…Alendronate acid, a bisphosphonate, is the primary agent used to prevent and treat osteoporosis (20)(21)(22). Pharmacokinetic studies have indicated that ~50% of the alendronate absorbed into the body binds to bone surface, while the other 50% is rapidly excreted from the kidneys (20,23,24). Besides conventional chemical therapy, stem cell therapy has been demonstrated to lead to an improvement in patients with osteoporosis by promoting osteo-in patients with osteoporosis by promoting osteo-by promoting osteogenesis and preventing the progression of osteoporosis (25,26).…”

Ulceração de anastomose esôfago-entérica causada por alendronato

“…O alendronato de sódio é uma droga aprovada pelo FDA (Food and Drug Administration) para prevenção e tratamento da osteoporose em mulheres pós-menopausadas, como alternativa eficaz à terapia de reposição estrogênica, especialmente para aquelas que não podem ou não farão o uso deste hormônio (5) . Recomenda-se que a droga seja tomada pelo menos 30 minutos antes da primeira alimentação ou bebida do dia com um copo cheio de água (180-240 mL), e que se evite deitar ao menos por um período de 30 minutos que sucedem a sua ingestão (2) …”