Alemtuzumab treatment for steroid-refractory acute graft-versus-host disease leads to severe immunosuppression but not to relapse of malignant disease

Philippen, Lennart; Schub, Natalie; Günther, Andreas; Cario, Gunnar; Schrappe, Martin; Repp, Roland; Gramatzki, Martin

doi:10.1038/s41409-023-02144-8

Bone Marrow Transplant

2023

DOI: 10.1038/s41409-023-02144-8

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Alemtuzumab treatment for steroid-refractory acute graft-versus-host disease leads to severe immunosuppression but not to relapse of malignant disease

Lennart Philippen,

Natalie Schub,

Andreas Günther

et al.

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2024

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Applications of Biological Therapy for Latent Infections: Benefits and Risks

Zong,

Kamoi,

Miyagaki

et al. 2024

IJMS

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Biological therapies have revolutionized medical treatment by targeting the key mediators or receptors involved in inflammatory responses, thereby effectively suppressing inflammation and achieving beneficial outcomes. They are more advanced than conventional therapies using corticosteroids and immunosuppressants, offering effective solutions for autoimmune diseases, cancer, transplant rejection, and various infectious diseases, including coronavirus disease 2019. Although they exert low immunosuppressive effects, biological therapies can reactivate specific biological targets associated with infections. This review summarizes the currently available biological therapies and discusses their immunosuppressive mechanisms and clinical applications, highlighting the variations in the types and frequencies of infection recurrence induced by different biological agents. Additionally, this review describes the risk factors associated with various biological agents, thus aiding clinicians in selecting the most appropriate biological therapy.

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Applications of Biological Therapy for Latent Infections: Benefits and Risks

Zong,

Kamoi,

Miyagaki

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Alemtuzumab treatment for steroid-refractory acute graft-versus-host disease leads to severe immunosuppression but not to relapse of malignant disease

Cited by 1 publication

References 11 publications

Applications of Biological Therapy for Latent Infections: Benefits and Risks

Applications of Biological Therapy for Latent Infections: Benefits and Risks

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