Aldrin epoxidase and dimethylhydrazine demethylase activities in tumorous and non-tumorous tissue of the human colon and rectum

Siegers, C.‐P.; Schumann, Sophia; Thies, E.; Böse-Younes, H.; Younes, Maged

doi:10.1016/0304-3835(84)90059-4

Cancer Letters

1984

DOI: 10.1016/0304-3835(84)90059-4

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Aldrin epoxidase and dimethylhydrazine demethylase activities in tumorous and non-tumorous tissue of the human colon and rectum

C.‐P. Siegers

Sophia Schumann

E. Thies

et al.

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1985

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Cited by 5 publications

(1 citation statement)

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“…Recently a distinct human microsomal GST has been described and purified (McLellan et al, 1989). In many malignant tumours the expression of GST is altered, with an increase in GST pi frequently reported (Di Ilio et al, 1987;Siegers et al, 1984;Batist et al, 1987;Tew et al, 1987;Shea et al, 1988). This has been implicated in tumour cell resistance to alkylating agents and other cytotoxic drugs Wolf et al, 1987).…”

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Glutathione S-transferase expression in fetal kidney and Wilms' tumour

Harrison

Hallam²,

Lauder³

1990

Br J Cancer

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The glutathione S-transferases (GSTs) have been implicated in carcinogenesis and tumour drug-therapy resistance. In this study GST pi was the predominant isoenzyme in the fetal human kidney. It was present in differentiated epithelial structures but never in the primitive mesenchyme. By contrast most cases of Wilms' tumours showed GST pi in both epithelial structures and undifferentiated blastema. The level of expression, as assessed by immunostaining, was no more than moderate, and was generally higher in differentiated elements. In only one case was GST alpha found in Wilms' tumour. This study had demonstrated a difference between fetal kidney and Wilms' tumour blastema in terms of GST expression. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11

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confidence: 99%

Glutathione S-transferase expression in fetal kidney and Wilms' tumour

Harrison

Hallam²,

Lauder³

1990

Br J Cancer

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Effect of iron overload on spontaneous and xenobiotic‐induced lipid peroxidation in vivo

Younes

Eberhardt

Lemoine

1989

J of Applied Toxicology

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To study the effect of iron-overload on hepatic lipid peroxidation, two rat models of haemochromatosis were employed: in the first model resembling secondary haemochromatosis, repeated i.p. injections with Fe-dextran led to an accumulation of Fe in Kupffer cells, while in the second model resembling hereditary haemochromatosis, iron was located mainly in periportal hepatocytes after feeding on a diet containing 3.5% Fe-fumarate for 3 weeks. In both models, total hepatic iron content was elevated four- to fivefold over controls. In vivo lipid peroxidation (ethane exhalation) was enhanced only in the second model, indicating that the hepatocytes are the main targets of Fe-induced lipid peroxidation. Low hepatotoxicity was observed in the second model. Additional treatment of the rats with hepatotoxic agents led to different results: with ethanol and bromobenzene, lipid peroxidation was only evident in both models of iron-overload, while paracetamol-induced lipid peroxidation was seen only in Fe-fumarate-fed rats. CCl4-induced lipid peroxidation was strongly enhanced in both models of haemochromatosis. Hepatotoxicity was enhanced by iron overload only in the case of CCl4-treated, Fe-fumarate-fed rats. The activities of phase I and phase II enzymes of xenobiotic metabolism were not markedly altered in livers of iron-overloaded rats. This implies that neither the bioactivation nor the detoxification of the agents studied were affected in experimental haemochromatosis.

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Rat liver cytochrome P-450 isozymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes

Wolff

Guengerich

1987

Biochemical Pharmacology

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Aldrin epoxidase and dimethylhydrazine demethylase activities in tumorous and non-tumorous tissue of the human colon and rectum

Cited by 5 publications

References 6 publications

Glutathione S-transferase expression in fetal kidney and Wilms' tumour

Glutathione S-transferase expression in fetal kidney and Wilms' tumour

Effect of iron overload on spontaneous and xenobiotic‐induced lipid peroxidation in vivo

Rat liver cytochrome P-450 isozymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes

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