Aldosterone Secretion Rates in Abnormal Pregnancy1

Watanabe, Mamoru; Meeker, Chris; Gray, Mary Jane; Sims, Ethan A. H.; Solomon, Samuel

doi:10.1210/jcem-25-12-1665

Cited by 44 publications

(4 citation statements)

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“…The small increases in plasma levels and blood production rates of aldosterone that we observed during late pregnancy contrast with the large elevations reported in the literature for production rate of aldosterone determined by "urinary" methods (13)(14)(15) (16). However, such metabolic changes will not influence the results of production rates which are obtained by the determination of the specific activity of a unique metabolite of aldosterone.…”

Section: Methodscontrasting

confidence: 89%

Transplacental passage and fetal secretion of aldosterone

Bayard¹,

Ances²,

Tapper³

et al. 1970

J. Clin. Invest.

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A B S T R A C T The transplacental passage and the production of aldosterone were studied in late pregnancy during a constant infusion of 1,2-aldosterone-3H to mothers at the time of elective cesarean section.It was found that, while maternal aldosterone crossed the placenta, there was a significant secretion of aldosterone by the fetus. The aldosterone concentration in fetal plasma was 2-12 times higher than that of the corresponding mothers.Pregnancy had no effect on the metabolic clearance rate of aldosterone, but it increased the rate of production of this steroid. However, the increments that we observed were smaller than those reported in previous reports. The discrepancy was probably due to differences in body posture, our subjects being supine for at least 10 hr at the time of study.

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Section: Methodscontrasting

confidence: 89%

Transplacental passage and fetal secretion of aldosterone

Bayard¹,

Ances²,

Tapper³

et al. 1970

J. Clin. Invest.

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“…Whether this alteration in the estradiol to progesterone ratio plays a role in the induction of labor by increasing the sensitivity of the myomertrium to oxytocin, as has been postulated in human gestation, is unknown (23,26). The marked increase in serum aldosterone observed in this study is also characteristic of human pregnancy, although it is known to be responsive to changes in salt intake (27). Similarly, the marked increase in PRA is consistent with the findings in human pregnancy (28).…”

Section: Discussionsupporting

confidence: 91%

Endocrine Profile of Pregnancy in the Patas Monkey (Erythrocebus patas)

et al. 1985

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Spontaneous toxemia occurs in approximately 6% of pregnancies in patas monkeys (Erythrocebus patas). To assess further the relevance of this animal as a model system for toxemia of pregnancy in humans, we characterized the endocrine profile of the patas pregnancy by analyzing weekly blood samples for estrone, estradiol, estriol, progesterone, aldosterone, and PRA throughout gestation. The profiles obtained bear striking resemblance to those described for human pregnancy, an unexpected finding since the patas monkey is not a higher hominoid. We conclude that the patas monkey may provide a model of toxemia relevant to study of the human disorder and is superior to other animal models which require surgical manipulation and are characterized by secondary hyperreninemia.

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“…Therefore, if DOC secretion in pregnancy is unresponsive to volume hyperexpansion, it would present a substantial nonsuppressible level of mineralocorticoid activity. During maternal complications such as preeclampsia, where aldosterone secretion may be appropriately depressed (16), persistently elevated DOC concentrations, although reported to be no higher than those measured in normotensive gravidas (8), might be excessive relative to the existing degree of sodium retention.…”

Section: Discussionmentioning

confidence: 90%

ACTH-Induced Sodium Retention in Pregnancy. Role of Desoxycorticosterone and Corticosterone*†

Ehrlich

Biglieri

Lindheimer

1974

The Journal of Clinical Endocrinology & Metabolism

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Continued administration of ACTH to normal gravidas results in marked sodium retention that is sustained, while aldosterone excretion declines below pretreatment levels. Since this is similar to results noted in nonpregnant subjects, where the cumulative sodium retention has been ascribed to increments in ACTH-dependent mineralocorticoids such as desoxycorticosterone (DOC) and corticosterone (B), a study was designed to evaluate effects of administered ACTH in pregnancy upon the urinary excretion of DOC and B metabolites, tetrahydro-DOC (THDOC) and tetrahydro-B (THB).Control values for urinary THDOC excretion in pregnant women were markedly elevated; THB was within or just slightly above the normal nonpregnant range. Urinary THDOC and THB excretion increased more than twofold during ACTH administration while aldosterone excretion was depressed. Thus, the marked sodium retention induced by ACTH in pregnant women may be related to increments in secretion of DOC and B, as in nongravidas. Furthermore, the finding of increased urinary THDOC excretion as well as observations by others of marked increments in plasma DOC concentrations indicate that DOC secretion is substantially elevated in normal pregnancy. (J Clin Endocrinol Metab 38: 701, 1974) A DMINISTRATION of ACTH to normal A third trimester gravidas is accompanied by striking sodium retention (1). Of interest is that during prolonged ACTH administration, aldosterone excretion increases transiently but then declines below pretreatment values while sodium retention persists. This is similar to results noted is nonpregnant subjects where the sodium retention that continues after aldosterone excretion declines has been ascribed to increments in ACTH-dependent mineralocorticoids, such as desoxycorticosterone (DOC) and corticosterone (B) (2). The present study was designed to evaluate the effects of administered ACTH in pregnancy upon the urinary excretion of DOC and B metabolites, tetrahydro-DOC (THDOC) and tetrahydro-B (THB) and to correlate these with alterations in electrolyte balance, the excretion of aldosterone and cortisol, and changes in serum renin activity.

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Aldosterone Secretion Rates in Abnormal Pregnancy1

Cited by 44 publications

References 0 publications

Transplacental passage and fetal secretion of aldosterone

Transplacental passage and fetal secretion of aldosterone

Endocrine Profile of Pregnancy in the Patas Monkey (Erythrocebus patas)

ACTH-Induced Sodium Retention in Pregnancy. Role of Desoxycorticosterone and Corticosterone*†

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