Aldosterone-Mediated Sodium Retention Is Reflected by the Serum Sodium to Urinary Sodium to (Serum Potassium)2 to Urinary Potassium (SUSPPUP) Index

Kanaan, Evelien; Vonend, Oliver; Reincke, Martín; Schott, M.; Willenberg, Holger S.

doi:10.3390/diagnostics10080545

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…None of the diagnosed PA patients was hypokalemic at screening. A study by Kanaan et al showed that a po-tassium concentration of 3.8 mmol/L or lower (" < 3.9 mmol/L") best-discriminated patients with PA from with EH when only this information is available [15]. In our study, 5 (45.5 %) of patients with PA had a serum-K below 3.9 mmol/L compared to 48 (26.7 %) (p = 0.179) of the non-PA subjects.…”

Section: Incidence Of Primary Aldosteronism In the Study Populationmentioning

confidence: 99%

Prevalence of Primary Aldosteronism in Newly Diagnosed Hypertensive Patients in Primary Care

Asbach

Kellnar

Bekeran

et al. 2022

Exp Clin Endocrinol Diabetes

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Context: Primary aldosteronism (PA) represents the most frequent cause of an endocrine arterial hypertension. PA is also common in patients with mild forms of hypertension and normokalemia. Objective: Our aim was to identify the prevalence of PA in newly diagnosed hypertensive patients in primary care in Southern Germany. Patients and methods: Newly diagnosed hypertensive patients in 27 primary care centers in Munich agreed to participate to the study. Patients had screening for PA with aldosterone to renin ratio (ARR). In case of elevated ARR, confirmation testing was performed. After diagnosis of PA, subtype differentiation and subsequent therapy of PA was initiated. Results: A total of 235 patients with newly discovered arterial hypertension were initially screened for PA. Of these patients, 35 were excluded because the medication indicated pre-existing treated arterial hypertension or they were on interfering antihypertensive medication. 2.0 % of the patients had hypokalemia at first screening. Of the 200 patients with newly discovered arterial hypertension, 42 had an elevated ARR. The incidence of the presence of a hypokalemia did not differ according to normal or pathological ARR. Nine patients (21 %) did not show up for further testing and were lost to follow-up, 33 patients underwent a saline infusion test. Of these, 11 patients were diagnosed with PA, leading to a prevalence of at least 5.5 % of PA in the collective. None of the diagnosed PA patients was hypokalemic at screening. Conclusion: Our data of untreated newly diagnosed patients with hypertension demonstrates a prevalence of 5.5 % of PA.

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Section: Incidence Of Primary Aldosteronism In the Study Populationmentioning

confidence: 99%

Prevalence of Primary Aldosteronism in Newly Diagnosed Hypertensive Patients in Primary Care

Asbach

Kellnar

Bekeran

et al. 2022

Exp Clin Endocrinol Diabetes

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“…Willenberg et al [11] and Kanaan et al [16] demonstrated increased SUSPUP and SUSPPUP ratios in patients with primary hyperaldosteronism. In such a setting, the lack of any significant differences in SUSPUP and SUSPPUP ratios (p = 0.36 and 0.35, respectively) also confirms, in our opinion, that hyperaldosteronism does not seem to play a significant role in the development of PIH.…”

Section: Discussionmentioning

confidence: 96%

Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension

Lewandowski

Tadros-Zins

Horzelski

et al. 2023

Exp Clin Endocrinol Diabetes

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Introduction We aimed to assess renin, aldosterone, and cortisol in the early stages of pregnancy-induced hypertension (PIH), i. e., at the time of diagnosis. Methods During the postural test, we measured aldosterone, renin [Liason DiaSorin Inc. (Italy)], as well as cortisol, sodium, potassium, and 24-h urinary sodium and potassium excretion in 62 women with newly diagnosed PIH, 70 healthy women during the 3rd trimester of pregnancy, and in 22 healthy non-pregnant women. Results In all groups, there was a significant increase in aldosterone and renin in upright versus supine posture (p<0.01). Both supine and upright aldosterone concentrations were higher in healthy pregnant women than in women with PIH and the lowest in healthy not-pregnant [supine (median±intequartile range): 25.04±18.4 ng/dL, 18.03±12.58 ng/dL, and 7.48±4.78 ng/dL, p<0.001, upright: 31.60±21.32 ng/dL, 25.11±13.15 ng/dL, and 12.4±12.4 ng/dL, p<0.001, for healthy pregnant, pregnant with PIH, and non-pregnant, respectively]. Supine renin concentrations were higher only in healthy pregnant (p<0.001), while in the upright position, there was a difference only between healthy pregnant and women with PIH (p=0.002). Both in supine and upright positions, there was no difference in the aldosterone-to-renin ratio between healthy pregnant women and women with PIH, though, in both groups, the ratio was higher than in non-pregnant women (p<0.001). Morning cortisol concentrations and 24-h urinary sodium excretion were lower in women with PIH than in healthy pregnant (p<0.001, p=0.002, respectively). Conclusion Hyperaldosteronism is not involved in the etiology of PIH. In PIH, there is also a tendency towards lower sodium excretion and lower morning cortisol concentrations.

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Association of a novel electrolyte index, SUSPPUP, based on the measurement of fasting serum and spot urinary sodium and potassium, with prediabetes and diabetes in Chinese population

Sang¹,

Liu²,

Wu³

et al. 2022

Clinica Chimica Acta

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Aldosterone-Mediated Sodium Retention Is Reflected by the Serum Sodium to Urinary Sodium to (Serum Potassium)2 to Urinary Potassium (SUSPPUP) Index

Cited by 3 publications

References 22 publications

Prevalence of Primary Aldosteronism in Newly Diagnosed Hypertensive Patients in Primary Care

Prevalence of Primary Aldosteronism in Newly Diagnosed Hypertensive Patients in Primary Care

Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension

Association of a novel electrolyte index, SUSPPUP, based on the measurement of fasting serum and spot urinary sodium and potassium, with prediabetes and diabetes in Chinese population

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