Aldosterone induced morphological changes in amphibian epithelia in vivo

Voûte, Cornelis L.; Hänni, S.; Ammann, Elias

doi:10.1016/0022-4731(72)90046-5

Cited by 42 publications

(2 citation statements)

References 4 publications

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“…The stratum corneum, the outermost, dead, cell layer, is shed; the underlying layer of cells, the stratum granulosum, cornifies and becomes the new s. corneum; and the layer of cells below that takes over the functions of the s. granulosum [19,27,28]. Transport properties of the skin are also affected.…”

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confidence: 97%

Aldosterone-induced moulting in amphibian skin and its effect on electrical capacitance

Smith

1975

J. Membrain Biol.

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The resistance and capacitance of the isolated amphibian skin have been determined from measurements of the response of the voltage across the skin to small steps to current. Previous work indicates that the electrical impedance of frog skin, when the skin is bathed with Ringer's solution on both sides, is largely determined by the properties of the functional outward-facing membrane of the skin, the outer membrane of the stratum granulosum (P.G. Smith, 1971, Acta Physiol. Scand. 81:355). This membrane can be represented by a resistance and capacitance in parallel. Aldosterone, which induces conversion of the s. granulosum into a cornified cell layer and transformation of the cell layer below into a new s. granulosum, also causes a transient rise in resistance and a short-lived decrease in capacitance to about one-half its initial value. It is suggested that these electrical changes are caused by the transitory presence of two functional outward-facing membranes in series. The method of determining resistance and capacitance from the voltage response is discussed in the Appendix.

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confidence: 97%

Aldosterone-induced moulting in amphibian skin and its effect on electrical capacitance

Smith

1975

J. Membrain Biol.

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“…Extensive experimental work has been devoted to trying to correlate known functions (Na +, H +, H20 transport) to these epithelial cells [6,15,17,18,20]. Little information is available on the underlying cells, termed basal cells.…”

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confidence: 99%

Microfilament-rich cells in the toad bladder epithelium

et al. 1979

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Basal cells of the bladder epithelium of Bufo marinus have been found heterogenous and consist of microfilament-rich cells (MFR-cell) and undifferentiated cells (Un-cell). The MFR-cell, which represents approximately 20% of the epithelial cell population, lies between the epithelial layer lining the urinary space and the basement membrane; it extends under several epithelial cells by processes of varying widths and lengths which contact, via desmosomes, other MFR-cells, as well as cells in the superficial layer, i.e., granular and mitochondria-rich cells. The cytoplasm of MFR-cell is filled with intermediate filaments arranged in bundles which run parallel to the plane of the epithelium and no dense granules, typical of granular cells, have been detected. Strong immunofluorescence for actin is associated with cells which occupy the same basal position as MFR-cells. Undifferentiated cells have no contact via desmosomes with adjacent cells and their cytoplasm is filled with free ribosomes; they lack bundles of intermediate filaments and possess no specialized organelles. After a 4-hr pulse of 3H-thymidine, 1.5% of epithelial cells incorporate thymidine into nuclear DNA, out of which 3/4 are basally and 1/4 are apically located. Identification of cell types by electron microscopy reveals that approximately 10% of undifferentiated basal cells are labeled, whereas less than 0.1% of granular cells and no MFR-cells incorporate 3H-thymidine into DNA. When dissociated from the epithelium and separated by isopycnic centrifugation, MFR-cells possess a mean buoyant density of approximately 1.025, cosediment with mitochondria-rich cells and exhibit a strong immunofluorescence for actin. The function of MFR-cells remains unknown; however, they may play a role in cell coupling and responses to hormonal and physical factors.

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Morphology of the exocrine glands of the frog skin

Mills

Prum

1984

Am. J. Anat.

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Frog skin contains three distinct types of exocrine glands: granular (poison), mucous, and seromucous. The granular gland forms a syncytial secretory compartment within the acinus, which is surrounded by smooth muscle cells. The mucous and seromucous glands are easily identifiable as distinct glands. The serous and mucous secretory cells are arranged in a semilunar configuration opposite the ductal end and are filled with granules. Within the acinus, located at the ductal pole of the gland, are distinct groups of cells with few or no granules in the cytoplasm. In both the mucous and seromucous gland there is a cell type with abundant mitochondria; the one in the mucous gland is located in the region adjacent to the secretory cells. The duct of these glands is two-layered, with the individual cells appearing morphologically similar to the layers of the skin epithelium as the duct traverses the skin. The duct appears to be patent throughout its length. The morphological heterogeneity and distinct distribution of the cell types within the gland acinus may be indicative of a functional heterogeneity that allows the production of distinctly different types of secretion from the same gland type, depending on the type of stimulus.

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Aldosterone induced morphological changes in amphibian epithelia in vivo

Cited by 42 publications

References 4 publications

Aldosterone-induced moulting in amphibian skin and its effect on electrical capacitance

Aldosterone-induced moulting in amphibian skin and its effect on electrical capacitance

Microfilament-rich cells in the toad bladder epithelium

Morphology of the exocrine glands of the frog skin

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