Aldosterone Excretion in Normal Subjects Depleted of Sodium and Potassium 1

Johnson, Ben B.; Lieberman, Amos H.; Mulrow, Patrick J.

doi:10.1172/jci103480

Cited by 68 publications

(16 citation statements)

References 21 publications

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“…In addition to apparent direct adrenal effects, potassium contributes to the control of aldosterone secretion by potentiating the actions of other stimulatory factors. Sodium depletion increases aldosterone secretion to a greater extent when subjects are potassium replete than when potassium deplete (2,4,9). Both in vivo and in vitro, potassium augments stimulation by angiotensin II and by ACTH (10)(11)(12).…”

Section: As Does Infusion Of Potassiummentioning

confidence: 97%

Role of angiotensin II in potassium-mediated stimulation of aldosterone secretion in the dog.

Pratt¹

1982

J. Clin. Invest.

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A B S T R A C T Potassium is known to enhance the aldosterone-stimulating action of angiotensin II. Such a synergistic interaction of potassium with angiotensin II could represent an action by angiotensin II to potentiate potassium as a stimulus. To examine for this effect of angiotensin II on potassium, plasma aldosterone levels were measured before and after an infusion of potassium chloride (15 meq i.v.) into dogs without and with prevention of angiotensin II formation by captopril, an angiotensin converting-enzyme inhibitor. In addition, responses to potassium were measured in a group of dogs receiving angiotensin II plus captopril. After potassium infusion, control dogs showed an increase of 7.7±1.9 (SEM) ng/dl (P < 0.001) in the level of plasma aldosterone. In contrast, captopril-treated dogs showed no change in plasma aldosterone concentration in response to potassium. When angiotensin II was administered to captopril-treated dogs responsiveness to potassium administration was restored (plasma aldosterone concentration increased by 7.4±2.1 ng/dl, P < 0.002). ACTH stimulated aldosterone secretion despite captopril treatment (P < 0.001), however, ACTH produced a greater increase in the plasma aldosterone concentration in controls than in captopriltreated animals. It is evident from these results that stimulation of aldosterone secretion by potassium is considerably enhanced by angiotensin II. There appears to exist an important interdependence of these stimuli in the regulation of aldosterone secretion.

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Section: As Does Infusion Of Potassiummentioning

confidence: 97%

Role of angiotensin II in potassium-mediated stimulation of aldosterone secretion in the dog.

Pratt¹

1982

J. Clin. Invest.

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“…The magnitude of the contribution of organic acids to titratable acid was estimated in some specimens from both normal and potassiumPotassium Depletion and Urine Acidification depleted studies. 31 specimens from normal studies had a ratio of organic acid titratable acidity to total urinary organic acids of 0.14 +0.O1SE, and nine specimens from potassium-depleted studies a ratio of 0.16 +0.02SE. Therefore, it is unlikely that the exclusion of organic acids from the calculation of titratable acid significantly influenced the interpretation of changes in either titratable acid or net acid excretion.…”

Section: Potassium Depletion and Urine Acidification 815mentioning

confidence: 98%

“…7. This pattern of electrolyte excretion most likely represents a decrease in distal sodium-cation exchange and probably is a result, at least in part, of the decrease in aldosterone secretion which accompanies potassium depletion (31)(32)(33). This apparently is one manner in which urinary potassium excretion is altered in response to potassium deficiency.…”

Section: Potassium Depletion and Urine Acidification 815mentioning

confidence: 99%

The effect of uncomplicated potassium depletion on urine acidification

Tannen¹

1970

J. Clin. Invest.

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“…Previous studies have shown that aldosterone production can be markedly influenced by changes in potassium ( [1][2][3][4][5]. It is still uncertain, however, whether the modulating effect of potassium is dependent upon gross changes in potassium balance or whether it may also occur in response to changes in plasma potassium concentration independently of changes in potassium balance.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Plasma Aldosterone Concentration by Plasma Potassium in Anephric Man in the Absence of a Change in Potassium Balance

Cooke¹,

Horvath²,

Moore³

et al. 1973

J. Clin. Invest.

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A B S T R A C T In studies on seven anephric patients, glucose and insulin administration before hemodialysis produced a significant reduction in plasma potassium concentration (mean reduction = 1.3, 1.7, and 1.4 meq/ liter at 60, 120, and 180 min, respectively) which was accompanied by a significant and sustained reduction in plasma aldosterone concentration. There was a significant correlation between plasma aldosterone and plasma potassium concentration (r = +0.74, P < 0.001) and between changes in the concentration of plasma aldosterone occurring in individual patients and the corresponding changes in plasma potassium concentration (r = +0.52, P < 0.01). There was no significant change in plasma sodium concentration, and plasma corticoid concentration, which was monitored as an index of ACTH elaboration, was reduced at 60 min but increased subsequently as symptoms attributable to hypoglycemia were observed.These studies demonstrate that plasma aldosterone concentration can be modulated acutely by transitory changes in plasma potassium concentration without a change in potassium balance. The effect of glucose and insulin administration on intracellular potassium in the adrenal cortex is uncertain, and although increased net movement of potassium into cells is the presumptive mechanism of the reduction in plasma potassium concen-

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Aldosterone Excretion in Normal Subjects Depleted of Sodium and Potassium 1

Cited by 68 publications

References 21 publications

Role of angiotensin II in potassium-mediated stimulation of aldosterone secretion in the dog.

Role of angiotensin II in potassium-mediated stimulation of aldosterone secretion in the dog.

The effect of uncomplicated potassium depletion on urine acidification

Modulation of Plasma Aldosterone Concentration by Plasma Potassium in Anephric Man in the Absence of a Change in Potassium Balance

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