Abstract:The excretion of potassium and the reabsorption of sodium were studied in isolated perfused kidneys of adrenalectomized rats following the administration of aldosterone. Aldosterone (10-7M) produced a rapid increase in fractional excretion of potassium, without affecting glomerular filtration rate, urine flow rate or sodium reabsorption. Spironolactone (10-4M) completely abolished the kaliuretic effect of aldosterone, while actinomycin D had no inhibitory effect. In the absence of exogeno… Show more
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