2006
DOI: 10.1080/08860220600779033
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Aldosterone Blockage in Proliferative Glomerulonephritis Prevents Not Only Fibrosis, but Proliferation as Well

Abstract: Studies performed recently have determined that aldosterone has not only a major role in electrolyte and water balance and K excretion, but it also modulates myofibroblast growth in the heart and blood vessels and causes fibrosis. This study investigated the effects of aldosterone blockers in rats with anti-thy 1.1 nephritis, both on proliferation and fibrosis, by comparing it to an angiotensin receptor inhibitor valsartan. Rats with anti-thy 1.1 nephritis were randomly allocated to one of the three following … Show more

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Cited by 20 publications
(19 citation statements)
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“…Evidence is available that aldosterone promotes fibroblast growth and proliferation 19 through activation of intracellular signal transduction pathways responsible for cell growth and differentiation that involve mitogen-activated protein kinases. 18 This has been documented in aldosterone-treated rats, in which activation of mitogen-activated protein kinases was prevented by concurrent treatment with eplerenone.…”
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confidence: 99%
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“…Evidence is available that aldosterone promotes fibroblast growth and proliferation 19 through activation of intracellular signal transduction pathways responsible for cell growth and differentiation that involve mitogen-activated protein kinases. 18 This has been documented in aldosterone-treated rats, in which activation of mitogen-activated protein kinases was prevented by concurrent treatment with eplerenone.…”
mentioning
confidence: 99%
“…18 This has been documented in aldosterone-treated rats, in which activation of mitogen-activated protein kinases was prevented by concurrent treatment with eplerenone. 19 By interacting with angiotensin II, aldosterone also increases the expression of plasminogen activator inhibitor-1 (PAI-1), which is known to promote accumulation of extracellular matrix 20 in endothelial cells. This signaling occurs through a glucocorticoid responsive element and serum-inducible element localized in the PAI-1 promot-er.…”
mentioning
confidence: 99%
“…Accumulating evidence also indicated that aldosterone may be involved in renal inflammation and fibrosis [3,13,17]. In most patients with chronic kidney disease, the plasma aldosterone concentration is increased and correlated with renal dysfunction [18].…”
Section: Discussionmentioning
confidence: 99%
“…Besides its basic role in controlling intracellular pH and cell volume, NHE1 also participates in certain physiological and pathological processes, such as cell proliferation, growth, migration and apoptosis in normal condition, as well as cancer cell invasion and heart failure [23]. Based on a possible link between aldosterone and NHE1 in organ fibrosis [3,24], we focused our present study on the potential role of NHE1 in mediating the effects of aldosterone on the production of fibronectin in cultured renal mesangial cells and its cell-signaling pathway. We found that the NHE1 protein expression was increased after the aldosterone treatment for 24 h. Our results also showed that aldosterone not only upregulated the expression of NHE1 in rat mesangial cells but also caused fibronectin accumulation.…”
Section: Discussionmentioning
confidence: 99%
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