Aldosterone and stress-dependent arterial hypertension

Antonov, E. V.; Markel, A. L.; Yakobson, G. S.

doi:10.1007/s10517-011-1484-8

Cited by 11 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic resonance imaging (MRI), MRI spectroscopy [7] Hypertrophy of renal corpuscles accompanied by structural changes that lead to an increase in the filtration barrier functional load and glomerular sclerosis Electron microscopic analysis [8] Characteristics of the neurohormonal system HPLC, immunohistochemistry [4,[9][10][11] Behavior…”

Section: Phenotype Approach Referencesmentioning

confidence: 99%

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Ryazanova,

Plekanchuk,

Prokudina

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Research into genetic and physiological mechanisms of widespread disorders such as arterial hypertension as well as neuropsychiatric and other human diseases is urgently needed in academic and practical medicine and in the field of biology. Nevertheless, such studies have many limitations and pose difficulties that can be overcome by using animal models. To date, for the purposes of creating animal models of human pathologies, several approaches have been used: pharmacological/chemical intervention; surgical procedures; genetic technologies for creating transgenic animals, knockouts, or knockdowns; and breeding. Although some of these approaches are good for certain research aims, they have many drawbacks, the greatest being a strong perturbation (in a biological system) that, along with the expected effect, exerts side effects in the study. Therefore, for investigating the pathogenesis of a disease, models obtained using genetic selection for a target trait are of high value as this approach allows for the creation of a model with a “natural” manifestation of the pathology. In this review, three rat models are described: ISIAH rats (arterial hypertension), GC rats (catatonia), and PM rats (audiogenic epilepsy), which are developed by breeding in the Laboratory of Evolutionary Genetics at the Institute of Cytology and Genetics (the Siberian Branch of the Russian Academy of Sciences).

show abstract

Section: Phenotype Approach Referencesmentioning

confidence: 99%

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Ryazanova,

Plekanchuk,

Prokudina

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Therefore, aldosterone is now considered as emotional stress hormone which plays an important contribution to the pathogenesis of stress‐dependent arterial hypertension (Antonov et al. ).…”

Section: Introductionmentioning

confidence: 99%

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice

2018

View full text Add to dashboard Cite

We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive in the face of double deleterious stresses, such as Ca2+‐homeostasis, pro/anti‐hypertrophic, endoplasmic reticulum stress (ER stress), pro‐ or anti‐apoptotic effectors, and MAP kinase activation, and redox signaling. These protein expressions were assessed by immunoblotting at 9 weeks after surgery. Female wild type (FWT) and FAS mice were fed with phytoestrogen‐free diet; underwent ovariectomy (Ovx) or sham‐operation (Sham). Ovx increased gain weight and hypertrophy index. Transthoracic echocardiograghy was performed. Both Ovx‐induced heart rate decrease and fractional shortening increase were associated with collagen type III shift. Cardiac estrogen receptor (ER α, ER β) protein expression levels were downregulated in Ovx mice. Hypoestrogenism increased plasma aldosterone and MR protein expression in FAS mice. Both aldosterone and Ovx played as mirror effects on up and downstream signaling effectors of calcium/redox homeostasis, apoptosis, such as concomitant CaMKII activation and calcineurin down–regulation, MAP kinase inhibition (ERK1/2, p38 MAPK) and Akt activation. The ratio Bcl2/Bax is in favor to promote cell survivor. Finally, myocardium had dynamically orchestrated multiple signaling cascades to restore tolerance to hostile environment thereby contributing to a better maintenance of Ca2+/redox homeostasis. Ovx‐induced collagen type III isoform shift and its upregulation may be important for the biomechanical transduction of the heart and the recovery of cardiac function in FAS mice. OVX antagonized aldosterone signaling pathways.

show abstract

Parameters of Blood Flow in Great Arteries in Hypertensive ISIAH Rats with Stress-Dependent Arterial Hypertension

et al. 2016

View full text Add to dashboard Cite

Magnetic resonance angiography was used to examine blood flow in great arteries of hypertensive ISIAH and normotensive Wistar rats. In hypertensive ISIAH rats, increased vascular resistance in the basin of the abdominal aorta and renal arteries as well as reduced fraction of total renal blood flow were found. In contrast, blood flow through both carotid arteries in ISIAH rats was enhanced, which in suggests more intensive blood supply to brain regulatory centers providing enhanced stress reactivity of these rats characterized by stress-dependent arterial hypertension.

show abstract

Aldosterone and stress-dependent arterial hypertension

Cited by 11 publications

References 8 publications

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice

Parameters of Blood Flow in Great Arteries in Hypertensive ISIAH Rats with Stress-Dependent Arterial Hypertension

Contact Info

Product

Resources

About