Aldose reductase inhibitory potential and anti-cataract activity of Punica granatum Linn. leaves against glucose-induced cataractogenesis in goat eye lens

Mestry, Snehal N.; Juvekar, Archana R.

doi:10.1007/s13596-017-0274-x

Cited by 11 publications

(6 citation statements)

References 24 publications

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“…Methanolic PGLE has been identified as an effective AGE inhibitor, reducing oxidative protein damage and maintaining protein thiol groups (S. N. Mestry et al, 2018 ). This anti-glycation effect, coupled with the reduction of fasting blood glucose and AGEs, underscores PGLE's role in delaying diabetic complications (S. N. Mestry & Juvekar, 2017 ). The extract's efficacy in inhibiting AGE formation has been corroborated by comparative studies with other medicinal plants, with PGLE showing exceptional activity ( Kaewnarin et al, 2014 ).…”

Section: Biological Activities and Human Health Of Pomegranate Leavesmentioning

confidence: 83%

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Unlocking the therapeutic treasure of pomegranate leaf: A comprehensive review on phytochemical compounds, health benefits, and future prospects

Yu,

Gouvinhas,

Chen

et al. 2024

Food Chemistry: X

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Section: Biological Activities and Human Health Of Pomegranate Leavesmentioning

confidence: 83%

“…The total flavonoid content (TFC) of methanolic PGL from Maharashtra, India (collected in January 2014) was 126.667 mg RE/g. Meanwhile, ethanolic PGL from Gujarat, India (collected in August 2012) had a TFC of 102.02 mg QE/g ( Ankita et al, 2015 ; S. N. Mestry & Juvekar, 2017 ).…”

Section: Phytochemicals Of Pomegranate Leavesmentioning

confidence: 99%

Unlocking the therapeutic treasure of pomegranate leaf: A comprehensive review on phytochemical compounds, health benefits, and future prospects

Yu,

Gouvinhas,

Chen

et al. 2024

Food Chemistry: X

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“…Researches on rats have been carried out to evaluate the inhibition ability of the biomaterials against AR enzymatic activity, obtained from Punica granatum leaves [40], Dendrobium aurantiacum var. denneanumis [41], Saraca indica [42], Zea mays leaves [43] and Chromolaena odorata leaves [48].…”

Section: Discussionmentioning

confidence: 99%

Anti-Cataract and Plant Extracts-Based Natural Products: A Review

Feriyani¹,

Darmawi²,

Lubis³

et al. 2021

Proceedings of the 1st Aceh International Dental Meeting (AIDEM 2019), Oral Health International Conference on Art, Nature and

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Cataracts are of concern to the world as one of the diseases that cause blindness. Diabetes mellitus has a relationship with cataracts due to hyperglycemia through polyol pathways that are converted to sorbitol by the aldose reductase enzyme. Polyol pathway has implications for the pathogenesis of the formation of diabetic cataracts. The use of anticataract drugs using plants is considered as a solution for the formation of diabetic cataracts. Several studies on plant material have been developed for the treatment of diabetic cataracts that assess the performance potential of bioactive compounds through inhibition of the enzyme Aldose Reductase. Studies from various recent research results provide information that plants as natural products have the potential for a large solution of diabetes cataract prevention and treatment.

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“…Aldose reductase breaks down surplus D-glucose into D-sorbitol with resultant change of reduced nicotinamide adenine dinucleotide phosphate (NADPH) into NADP+. The inception of NADP+ is documented at a wavelength of 340 nm for 3 minutes [ 23 ]. In this assay, the extract was disintegrated in phosphate-buffered saline (PBS).…”

Section: Methodsmentioning

confidence: 99%

Anticataract Effect of the Aqueous Extract of the Flowers of Aspilia africana in Murine Model of Diabetic and Age-Related Cataracts

Amanfo

Kyei

Boakye

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

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Background. The use of Aspilia africana in traditional medicine for the management of ocular diseases has been reported in India and some indigenous communities of Africa. The aim of this study was to investigate the aqueous extract of the flowers of A. africana (AAE) as an anticataract remedy using murine models of diabetic and senile cataracts. Methods. Preliminary phytochemical screening of the extract, in vitro antioxidant assays, and in vitro aldose reductase inhibitory activity were performed. For anticataract investigations of the extracts, diabetic cataract was induced by galactose administration in 3-week-old Sprague Dawley rats. The evaluation of experimentally induced age-related cataract was performed by administering sodium selenite to 10-day-old rat pups. Results. The phytochemical analysis revealed the presence of alkaloids, tannins, flavonoids, glycosides, and saponins. In vitro aldose reductase inhibitory property of the extract on rat lenses revealed that the AAE inhibited the enzyme activity with IC50 of 12.12 µg/ml. For the anticataract investigations, 30, 100, and 300 mg·kg−1AAE-treated rats recorded significantly low ( p ≤ 0.0001 ) cataract scores compared to the negative control rats, indicating a delay in cataractogenesis from the second week of treatment in the galactose-induced cataractogenesis. Similarly, the treatment with AAE caused a significant reduction ( p ≤ 0.0001 ) in cataract scores compared to the negative control rats in the selenite-induced cataractogenesis. Markers of lens transparency, such as aquaporin 0, alpha-A crystallin, and total lens proteins and lens glutathione levels, were significantly preserved ( p ≤ 0.05 – 0.0001 ) in each cataract model after AAE treatment. Conclusion. The study established the anticataract potential of the aqueous extract of flowers of A. africana in murine models, hence giving scientific credence to its folkloric use in the management of cataract.

show abstract

Aldose reductase inhibitory potential and anti-cataract activity of Punica granatum Linn. leaves against glucose-induced cataractogenesis in goat eye lens

Cited by 11 publications

References 24 publications

Unlocking the therapeutic treasure of pomegranate leaf: A comprehensive review on phytochemical compounds, health benefits, and future prospects

Unlocking the therapeutic treasure of pomegranate leaf: A comprehensive review on phytochemical compounds, health benefits, and future prospects

Anti-Cataract and Plant Extracts-Based Natural Products: A Review

Anticataract Effect of the Aqueous Extract of the Flowers of Aspilia africana in Murine Model of Diabetic and Age-Related Cataracts

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