Aldose Reductase Inhibitory and Antiglycation Activities of Four Medicinal Plant Standardized Extracts and Their Main Constituents for the Prevention of Diabetic Complications

Rao, Ajmeera Rama; Shyam, Panga; Veeresham, Ciddi; Asres, Kaleab

doi:10.4314/epj.v31i1.1

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…The number of enzymes that involve as catalysts for the 1 μmol NADPH/ h/100 mg protein oxidation. TRIzol reagent was used to extract total RNA from the lens, and the real-time reverse transcription polymerase chain reaction (RT-PCR) technique was used to measure the AR mRNA expression [27] .…”

Section: Estimation Of Mrna and Aldose Reductase Activity In Rat Lensesmentioning

confidence: 99%

Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats

Wang¹,

Wu²

2023

Int J Ophthalmol

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AIM: To investigate the aldose reductase (AR) inhibition capacity of astragalin (AST) against streptozoticin-induced diabetic cataracts (DCs) in rats. METHODS: Ex vivo investigations were conducted by treating the lens of a goat placed for 72h in artificial aqueous humor (AAH) of pH 7.8 at room temperature with cataract-causing substance (55 mmol/L of galactose) and in vivo studies were performed on rats via induction with streptozotocin. AST was administered at different dose levels and scrutinize for DC activity. RESULTS: In diabetic rats, AST improved the body weight, blood insulin, and glucose as well as the levels of galactitol in a dose-dependent way, other biochemical parameters i.e. inflammatory mediators and cytokines, and also suppress AR activity. The level of the antioxidant parameters such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) activity were also altered on a diabetic lens after the administration of the AST. CONCLUSION: AST protects against lens opacification to avoid cataracts and polyols formation, indicating that it could be used as a potential therapeutic agent for diabetes.

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Section: Estimation Of Mrna and Aldose Reductase Activity In Rat Lensesmentioning

confidence: 99%

Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats

Wang¹,

Wu²

2023

Int J Ophthalmol

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“…Rao et al [ 70 ] evaluated in vitro biological activity of standardized extracts of plants, including Morus alba extract containing morusin and its derivatives, in treatment of long-term diabetic complications. They assessed the inhibitory activity of the extract to aldose reductase (AR) and advanced glycation end products (AGEs) formation.…”

Section: Biological Effects Of Morusin and Its Derivativesmentioning

confidence: 99%

The Pro-Health Benefits of Morusin Administration—An Update Review

Panek-Krzyśko

Stompor-Gorący

2021

Nutrients

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Prenylflavonoids are widespread in nature. Plants are valuable sources of natural polyphenolic compounds with isoprenyl groups, which include flavones, flavanones, chalcones and aurones. They can be found in flowers, bark and stems. One of the most important compounds found in the bark of white mulberry (Morus alba) is morusin, a prenylated flavone with interesting pro-health properties. The research carried out so far revealed that morusin has antioxidant, antitumor, anti-inflammatory and anti-allergic activity. Moreover, its neuroprotective and antihyperglycemic properties have also been confirmed. Morusin suppresses the growth of different types of tumors, including breast cancer, glioblastoma, pancreatic cancer, hepatocarcinoma, prostate cancer, and gastric cancer. It also inhibits the inflammatory response by suppressing COX activity and iNOS expression. Moreover, an antimicrobial effect against Gram-positive bacteria was observed after treatment with morusin. The objective of this review is to summarize the current knowledge about the positive effects of morusin on human health in order to facilitate future study on the development of plant polyphenolic drugs and nutraceutics in the group of prenylflavones.

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Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism

Mahmoud

Abdel-Reheim

2016

Eur J Nutr

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Aldose Reductase Inhibitory and Antiglycation Activities of Four Medicinal Plant Standardized Extracts and Their Main Constituents for the Prevention of Diabetic Complications

Cited by 5 publications

References 32 publications

Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats

Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats

The Pro-Health Benefits of Morusin Administration—An Update Review

Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism

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