Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis

Li, Xiang; Chen, Yu; Luo, Yun; Lin, Jiacheng; Wang, Fang; Sun, Xuehua; Gao, Yueqiu; Tan, Weifeng; Xia, Qiang; Kong, Xiaoni

doi:10.7150/ijbs.59068

Cited by 14 publications

(6 citation statements)

References 50 publications

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“…Angiogenesis is involved in the progression of perihilar cholangiocarcinoma [27] . Glycolysis plays a vital role in tumor cell proliferation and invasion in cholangiocarcinoma [28] . Downregulation of Notch1 signaling was suggested as a promising strategy for inhibiting tumor cell development and progression in cholangiocarcinoma [29] .…”

Section: Discussionmentioning

confidence: 99%

Machine learning developed an intratumor heterogeneity signature for predicting prognosis and immunotherapy benefits in cholangiocarcinoma

Chen,

Sun,

Chen

et al. 2024

Translational Oncology

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Section: Discussionmentioning

confidence: 99%

Machine learning developed an intratumor heterogeneity signature for predicting prognosis and immunotherapy benefits in cholangiocarcinoma

Chen,

Sun,

Chen

et al. 2024

Translational Oncology

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“…previous studies demonstrated that glycolysis, as metabolic reprogramming, contributed significantly to cholangiocarcinoma initiation and progression [ 43 , 44 ] Glycolic pathways and enzymes, including pyruvate kinase M2 [ 45 , 46 ], Aldolase A [ 47 ] and lactate dehydrogenase A [ 48 ], play a critical role in BTC and have been utilized as biomarkers to predict patients` outcomes. Targeting glycolysis could be considered as a promising treatment option in BTC [ 49 – 51 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of 18F-Fluorodeoxyglucose positron-emission tomography parameters in patients with biliary tract cancers: a meta-analysis

Zheng,

Shi,

Kulabieke

et al. 2024

BMC Med Imaging

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Background and objective Numerous previous studies have assessed the prognostic role of 18F-fluorodeoxyglucose positron-emission tomography (18F FDG PET) in patients with biliary tract cancer (BTC), but those results were inconsistent. The present study aims to determine the predictive value of 18F FDG PET in BTC patients via a meta-analysis. Methods The underlying studies related to 18F FDG PET and BTC patients` outcomes were searched and identified in the online databases. The interested parameters include total lesion glycolysis (TLG), metabolic tumor volume (MTV), primary tumor and metastatic lymph node (LN) maximum standardized uptake value (SUVmax), as well as change of SUVmax (ΔSUVmax) during treatment. Overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were considered as the primary endpoints. Hazard ratio (HR) and corresponding 95% confidence intervals (CIs) were defined as the effective measure and calculated by a pooled analysis. Publication bias was assessed by funnel plot, Bagg’s and Egger’s tests. Results Totally, 23 studies involving 1478 patients were included in the present meta-analysis. After a pooled analysis, it revealed that a high SUVmax was significantly associated with a poor OS (HR:2.07, 95%CI: 1.74–2.46, P = 0.000) and DFS (HR: 2.28, 95%CI: 1.53–3.41, P = 0.000). In addition, an increased TLG level contributed to a shorter OS (HR:1.91, 95%CI: 1.26–2.90, P = 0.002) and DFS (HR: 4.34, 95%CI: 1.42–13.27, P = 0.01). Moreover, we confirmed that an elevated MTV was significantly associated with increased mortality (HR:2.04, 95%CI:1.26–3.31, P = 0.004) and disease relapse (HR: 3.88, 95%CI:1.25–12.09, P = 0.019) risks. Besides, the present study uncovered that increased ΔSUVmax could predict poor OS (HR:1.26, 95%CI:1.06–1.50, P = 0.008) instead of PFS (HR: 1.96, 95%CI: 0.82–4.72, P = 0.280). Lastly, we found that LN SUVmax did not link to OS (HR: 1.49, 95%CI: 0.83–2.68, P = 0.178). No obvious publication bias was detected in the present study. Conclusion 18F FDG PET parameters, including SUVmax, TLG, MTV, and ΔSUVmax, could be applied as convenient and reliable factors for predicting BTC patients` outcomes.

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“…where ϕ F is the fluorescence quantum yield, A is the absorbance, I f is the integration of the fluorescence band, and n is the solvent refractive index. The subscripts s and x refer to the standard and unknown samples, respectively [24]. In this work, the fluorescence quantum yield standards were solutions of 10 or 20 µM of 1,4-bis(5-phenyloxazol-2-yl)benzene (POPOP) in cyclohexane.…”

Section: Methodsmentioning

confidence: 99%

“…Cancer cells take up glucose and supply their energy requirements through anaerobic glycolysis; in these cells, ALDOA is overexpressed [23]. Indeed, certain ALDOA inhibitors have demonstrated antitumor activity [24,25]. Another attractive application of fluorescent probes is their utility as theranostic agents [26,27].…”

Section: Introductionmentioning

confidence: 99%

Turn-on Coumarin Precursor: From Hydrazine Sensor to Covalent Inhibition and Fluorescence Detection of Rabbit Muscle Aldolase

Amer,

Miles,

Firer

et al. 2024

Molecules

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Hydrazine, a highly toxic compound, demands sensitive and selective detection methods. Building upon our previous studies with pre-coumarin OFF–ON sensors for fluoride anions, we extended our strategy to hydrazine sensing by adapting phenol protecting groups (propionate, levulinate, and γ-bromobutanoate) to our pre-coumarin scaffold. These probes reacted with hydrazine, yielding a fluorescent signal with low micromolar limits of detection. Mechanistic studies revealed that hydrazine deprotection may be outperformed by a retro-Knoevenagel reaction, where hydrazine acts as a nucleophile and a base yielding a fluorescent diimide compound (6,6′-((1E,1′E)-hydrazine-1,2diylidenebis(methaneylylidene))bis(3(diethylamino)phenol, 7). Additionally, our pre-coumarins unexpectedly reacted with primary amines, generating a fluorescent signal corresponding to phenol deprotection followed by cyclization and coumarin formation. The potential of compound 3 as a theranostic Turn-On coumarin precursor was also explored. We propose that its reaction with ALDOA produced a γ-lactam, blocking the catalytic nucleophilic amine in the enzyme’s binding site. The cleavage of the ester group in compound 3 induced the formation of fluorescent coumarin 4. This fluorescent signal was proportional to ALDOA concentration, demonstrating the potential of compound 3 for future theranostic studies in vivo.

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Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis

Cited by 14 publications

References 50 publications

Machine learning developed an intratumor heterogeneity signature for predicting prognosis and immunotherapy benefits in cholangiocarcinoma

Machine learning developed an intratumor heterogeneity signature for predicting prognosis and immunotherapy benefits in cholangiocarcinoma

Prognostic significance of 18F-Fluorodeoxyglucose positron-emission tomography parameters in patients with biliary tract cancers: a meta-analysis

Turn-on Coumarin Precursor: From Hydrazine Sensor to Covalent Inhibition and Fluorescence Detection of Rabbit Muscle Aldolase

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