Aldol Insights: The Route to Chiral Synthesis of 3‐Substituted 3‐Hydroxy‐2‐Oxindoles

Abstract

This research article explores the recent advancements in the enantioselective synthesis of 3‐substituted‐3‐hydroxyoxindoles, vital intermediates in drug development. Utilizing various catalysts, including prolinamides, peptides, and metal‐catalyzed reactions, the study showcases the evolution of asymmetric aldol reactions over the past 6–7 years. Notable innovations include eco‐friendly approaches, such as on‐water catalysis, and the strategic use of chiral thiourea catalysts. Emphasizing the intricate relationship between molecular structure and biological activity, the review provides valuable insights into the current state of asymmetric synthesis and foreshadows future possibilities in tailored molecular design for medicinal applications.