Aldol and Related Processes

Bestimmte Silberkomplexe katalysieren selektiv entweder die Allenylierung oder asymmetrische Propargylierung von Ketonen. Ohne Ligand entstehen Allenylalkohole als Hauptprodukte, der Zusatz des Liganden Walphos‐8 ergibt enantiomerenangereicherte Homopropargylalkohole. Die Methode kann auf die Umwandlung von prochiralen Diarylketonen in enantiomerenangereicherte tertiäre Diarylalkohole angewendet werden.

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Silver‐Catalyzed Allenylation and Enantioselective Propargylation Reactions of Ketones

Kohn

Ichiishi

Jarvo

2013

Angew Chem Int Ed

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More than a silver lining: Certain silver complexes are capable of selective catalysis of either allenylation or asymmetric propargylation reactions of ketones. Ligand‐free conditions lead to allenyl alcohols as the major product, whereas ligation with Walphos‐8 gives enantioenriched homopropargyl alcohols. This method can be applied to reactions of prochiral diarylketones to provide optically enriched tertiary diaryl alcohols.

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Aldol and Related Processes

Cited by 4 publications

References 53 publications

Recent Advances in the Field of Naturally Occurring 5,6‐Dihydropyran‐2‐ones

Recent Advances in the Field of Naturally Occurring 5,6‐Dihydropyran‐2‐ones

Silver‐Catalyzed Allenylation and Enantioselective Propargylation Reactions of Ketones

Silver‐Catalyzed Allenylation and Enantioselective Propargylation Reactions of Ketones

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