“…Carbamate insecticides are considered safer than organophosphate (OP) insecticides because they produce poisoning by virtue of reversible inhibition of acetylcholinesterase (AChE). Aldicarb, which is not only one of the most toxic carbamates, but also more toxic than several OP insecticides, has recently been encountered in several accidental poisonings in animals [Spierenburg et al, 1985;Dorman et al, 1990;Kerr et al, 19911 as well as in humans [Goes et al, 1980;Lee and Ransdell, 1984;Parks et al, 1987;Goldman et al, 19901. Although the mechanism of toxic action of aldicarb is reported to be similar to other carbamate insecticides, i.e., reversible AChE inhibition at the synapses and neuromuscular junctions [Casida, 1963;O'Brien, 1967;Cambon et al, 19791 leading into accumulation of acetylcholine, the toxic manifestations differ very widely. For example, carbofuran, propoxur, and carbaryl produced toxic signs involving central as well as peripheral nervous systems [Gupta andKadel, 1989a,b, 1990b1, whereas, aldicarb in preliminary studies exhibited signs predominantly of the peripheral nervous system.…”