ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension

Mei, Xiaofei; Hu, Shengda; Liu, Pengfei; Li, Fēi; Zhou, Xingping; Zhou, Yafeng; Tan, Chongqing

doi:10.1536/ihj.19-259

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…KEGG analysis revealed that the DEGs were involved in several pathways, including the "endocrine system", "cardiovascular diseases", and "neurodegenerative diseases". Hypertension is associated with a reduction in key enzymes that maintain cardiac homeostasis, such as ALDH2 [22][23][24] . However, the ability of these enzymes could be increased by enhanced catalytic activity to counteract the cytotoxic aldehydes produced by lipid peroxidation during hypertension 25 and improved ventricular dysfunction caused by hypertension 26 .…”

Section: Discussionmentioning

confidence: 99%

Exploring the Mechanisms of Acupuncture-Induced Lowering of Blood Pressure Through Positron Emission Tomography and RNA Sequencing of the PVH

Peng

Lai

et al. 2020

Preprint

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Manual acupuncture (MA) can be used to manage high blood pressure, however, the underlying molecular mechanism remains unknown. To explore the mechanism of acupuncture in the treatment of hypertension, we used Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) that were subject to either MA stimulation or the corresponding sham procedure as a negative control (sham-MA) for 1 week. Blood pressure was recorded regularly. After 7 days of treatment, PET-CT scans were used to detect brain areas where glucose metabolism was significantly regulated. Additionally, the differentially expressed genes(DEGs) of a specific brain region—the paraventricular hypothalamic nucleus (PVH)—were evaluated by transcriptomics, and verified with quantitative PCR (qPCR). Eight overlapping DEGs were found between the WKY, SHR, and MA groups. The DEGs were then annotated with the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. qPCR was used to verify the DEGs. These genes may lower blood pressure by regulating angiotensin, endothelial function and inflammation, ect. This study reveals MA regulates multiple biological processes and genes of the PVH, and provides a solid theoretical basis for exploring the mechanisms by which MA manages hypertension.

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Section: Discussionmentioning

confidence: 99%

Exploring the Mechanisms of Acupuncture-Induced Lowering of Blood Pressure Through Positron Emission Tomography and RNA Sequencing of the PVH

Peng

Lai

et al. 2020

Preprint

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“…Previously, a link with the cardiovascular disease and hypertension for some of these genes and their protein products was established. Thus, BRAP gene variants were found to be associated with the risk of carotid atherosclerosis (Liao et al, 2011); protein products of genes ATXN2 and SH2B3 were involved in AH development (Siedlinski et al, 2020); rs671 of ALDH2 gene was associated with a decrease in the risk of AH development (Mei et al, 2020). For the variant rs11065987, an association with many pathological conditions was registered, including the level of lipids in blood (Willer et al, 2013), body mass index (Locke et al, 2015), ischemic stroke, ischemic heart disease (Dichgans et al, 2014) and AH (Levy et al, 2009).…”

Section: Assessment Of the Regulatory Potential Of Snps Associated With Arterial Hypertensionmentioning

confidence: 99%

Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype

et al. 2022

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Linkage disequilibrium (LD) of single nucleotide polymorphisms (SNPs) of TLR4/AL160272.2 (rs1927914, rs1928298, rs7038716, rs7026297, rs7025144) was estimated in the Slavs of West Siberia. We further investigated an association of SNPs in TLR4/AL160272.2 (rs1927914, rs7038716, rs7025144), SERPINA1 (rs1980616), ATXN2/BRAP (rs11065987), IL2RB (rs2284033), NT5C2 (rs11191582), CARD8 (rs11669386), ANG/RNASE4 (rs1010461), and ABTB2/ САТ (rs2022318) genes with bronchial asthma (BA), arterial hypertension (AH) and their comorbidity. Then, the disease-associated SNPs were annotated in silico in relation to their potential regulatory functions. Strong LD was detected between rs1928298 and rs1927914, as well as rs7026297 and rs7038716 in the Slavs of West Siberia. It was found that the rs1927914 G allele of the TLR4 gene and the rs1980616 C allele of the SERPINA1 gene are associated with the predisposition to BA. These SNPs can affect binding affinity of transcription factors of the Pou and Klf4 families, as well as the expression levels of the TLR4 and SERPINA1 genes. The rs11065987 allele A of the ATXN2/BRAP genes, the rs11669386 A allele of the CARD8 gene, the rs2284033 allele G of the IL2RB gene, and the rs11191582 allele G of the NT5C2 gene were associated with the risk of AH. These variants can alter binding affinity of the Hoxa9, Irf, RORalpha1 and HMG-IY transcription factors, as well as the expression levels of the ALDH2, CARD8, NT5C2, ARL3, and SFXN2 genes in blood cells/vessels/heart, respectively. The risk of developing a comorbid phenotype of AD and AH is associated with the A allele of rs7038716 and the T allele of rs7025144 of the TLR4/AL160272.2 genes, the A allele of rs1010461 of the ANG gene and the C allele of rs2022318 of the ABTB2/CAT genes. Variants rs7038716 and rs7025144 can change the expression levels of the TLR4 gene in blood cells, while rs1010461 and rs2022318 influence the expression levels of the ANG and RNASE4 genes as well as the CAT and ABTB2 genes in blood cells, lungs/vessels/heart.

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“…On the other hand, the case–control studies indicate that the deficiency of ALDH2 activity affects the risk of cardiovascular and neurodegenerative diseases. Mei et al [ 3 ] showed that the presence of ALDH2* 2/2 (rs67) variant was related to the reduction in the risk of essential hypertension (EH). The authors even put forward the thesis that this variant of ALDH2 could be an attractive candidate for genetic therapy of EH [ 3 ].…”

Section: Commentarymentioning

confidence: 99%

“…Mei et al [ 3 ] showed that the presence of ALDH2* 2/2 (rs67) variant was related to the reduction in the risk of essential hypertension (EH). The authors even put forward the thesis that this variant of ALDH2 could be an attractive candidate for genetic therapy of EH [ 3 ].…”

Section: Commentarymentioning

confidence: 99%

A commentary on the paper: ‘Evaluation of spice and herb as phytoderived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method’

Bilska‐Wilkosz

2022

Bioscience Reports

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It is commonly known that aldehyde dehydrogenases (ALDHs) are a promising therapeutic target in many diseases. Bui et al. - the authors of the paper I am discussing here (Biosci Rep (2021) 41(5): BSR20210491; DOI: https://doi.org/10.1042/BSR20210491) - point that there is a lack of research on the use of spices and herbs as the sources of naturally occurring modulators of ALDH activity. In order to carry out this type of research, the authors prepared ethanolic extracts of 22 spices and herbs. The main objective of the study was to investigate retinaldehyde dehydrogenases (RALDHs), of which retinal is the main substrate and ALDH2, the mitochondrial isoform, having acetaldehyde as the main substrate. The obtained results indicated that the tested extracts exhibited differential regulatory effects on RALDHs/ALDH2 and some of them showed a potential selective inhibition of the activity of RALDHs.

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ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension

Cited by 10 publications

References 18 publications

Exploring the Mechanisms of Acupuncture-Induced Lowering of Blood Pressure Through Positron Emission Tomography and RNA Sequencing of the PVH

Exploring the Mechanisms of Acupuncture-Induced Lowering of Blood Pressure Through Positron Emission Tomography and RNA Sequencing of the PVH

Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype

A commentary on the paper: ‘Evaluation of spice and herb as phytoderived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method’

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