Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Minato, Takuya; Yamamoto, Yota; Seike, Junici; Yoshida, Takahiro; Yamai, Hiromichi; Takechi, Hirokazu; Yuasa, Yasuhiro; Furukita, Yoshihito; Goto, Masakazu; Bando, Yoshimi; Tangoku, Akira

doi:10.1245/s10434-012-2535-8

Cited by 22 publications

(17 citation statements)

References 29 publications

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“…The by‐products of this metabolic process increase the self‐renewal ability of mesenchymal stem cells . ALDH1 activity is found in neoplastic cells, which show proliferative ability similar to that observed in stem cells and tumors with aggressive clinical behavior .…”

Section: Introductionmentioning

confidence: 79%

“…Highly tumorigenic cancer stem‐like cells present in HNSCC have been considered responsible for the aggressive biological behavior of this tumor . Most studies available in the literature describe the use of cell culture techniques, flow cytometry, or transplantation assays in animal models to detect highly tumorigenic cells and thus assess the pathobiology of HNSCC .…”

Section: Discussionmentioning

confidence: 99%

“…The combination of markers that allow the identification of these cells is known to be tumor dependent. In HNSCCs, the markers most commonly used to identify highly tumorigenic cells are CD44 and aldehyde dehydrogenase 1 (ALDH1; ).…”

Section: Introductionmentioning

confidence: 99%

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Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas

Hildebrand

Carvalho

Lauxen

et al. 2014

J Oral Pathology Medicine

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas

Hildebrand

Carvalho

Lauxen

et al. 2014

J Oral Pathology Medicine

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“…In addition, BMI1 overexpression was correlated to advanced pathological stage and lymph node metastasis in ESCC and EAC [102,103]. Clinical studies have also revealed that EpCAM [95,104], ABCG2 [100], ALDH1 [96,105], NANOG [106], GLI1 [107,108], and CD24 [109] could be considered as CSC markers in ESCC, since their expression was associated with clinicopathological characteristics of tumors.…”

Section: Esophagusmentioning

confidence: 98%

“…Furthermore, the expression of OCT4 and SOX2 was significantly associated with higher histological grade and poorer survival of ESCC [93,94]. In addition, expression of CD133 [82] and CD44 [79,95,96], specifically CD44v6 [97,98], was associated with clinicopathological features of ESCC and EAC, although a number of studies reported contradictive results [99][100][101]. In addition, BMI1 overexpression was correlated to advanced pathological stage and lymph node metastasis in ESCC and EAC [102,103].…”

Section: Esophagusmentioning

confidence: 99%

Cancer stem cells in human digestive tract malignancies

2015

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Digestive tract malignancies, including oral, pharyngeal, esophageal, gastric, and colorectal cancers, are among the top 10 most common cancers worldwide. In spite of using various treatment modalities, cancer patients still suffer from recurrence and metastasis of malignant cells. Cancer stem cells (CSCs) are undifferentiated and highly proliferative malignant cells with unique properties mediated by overexpression of stemness markers, metastasis-related proteins, drug transporters, and DNA repair machinery. Due to their salient characteristics, it has been suggested that CSCs are responsible for tumor initiation, progression, invasion, recurrence, and therapy resistance. Exploring different aspects of CSC biology has fueled a great enthusiasm in designing novel therapeutic strategies to help patients. For instance, identification of markers associated with digestive tract CSCs, such as CD44, CD133, CD24, EpCAM, LGR5, ALDH1, and BMI1, has made it possible to develop more accurate diagnosis approaches. In addition, specifically targeting CSCs by their markers imposes fewer side effects and improves therapeutic outcomes. Here, we focus on the current status of CSC biology in digestive tract cancers, with emphasis on CSC markers, and review achieved progress in eradication of digestive tract CSC cells.

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Biomarkers for predicting future metastasis of human gastrointestinal tumors

Poon

Pang

2013

Cell. Mol. Life Sci.

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The recent advances in surgery and radiation therapy have significantly improved the prognosis of patients with primary cancer, and the major challenge of cancer treatment now is metastatic disease development. The 5-year survival rate of cancer patients who have distant metastasis at diagnosis is extremely low, suggesting that prediction and early detection of metastasis would definitely improve their prognosis because suitable patient therapeutic management and treatment strategy can be provided. Cancer cells from a primary site give rise to a metastatic tumor via a number of steps which require the involvement and altered expression of many regulators. These regulators may serve as biomarkers for predicting metastasis. Over the past few years, numerous regulators have been found correlating with metastasis. In this review, we summarize the findings of a number of potential biomarkers that are involved in cadherin-catenin interaction, integrin signaling, PI3K/Akt/mTOR signaling and cancer stem cell identification in gastrointestinal cancers. We will also discuss how certain biomarkers are associated with the tumor microenvironment that favors cancer metastasis.

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Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Abstract: ALDH1 was found to be a predictor of postoperative recurrence and prognosis in ESCC, and CD44 might be a predictor of recurrence and prognosis. ALDH1 expression might affect the treatment strategy for ESCC.

Cited by 22 publications

References 29 publications

Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas

Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas

Cancer stem cells in human digestive tract malignancies

Biomarkers for predicting future metastasis of human gastrointestinal tumors

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