Aldehyde dehydrogenase 1 expression in invasive breast carcinoma and its correlation with other clinicopathological parameters

Farrag, MayadaS; Elmetwally, Mohamed; Farrag, Nesrine Saad; Ibrahiem, AfafT

doi:10.4103/egjp.egjp_23_22

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…The phenomenon, called “cadherin switch” has been implicated, often described in other types of cancer, i.e. breast cancer or ovarian cancer ( 58 , 59 ), but also in EC ( 29 ). We compared the expression of cadherins with nonparametric test, comparing the mean H-score value, like other studies ( 39 , 41 ), since cut-off for defining positive or negative expression of cadherins has not been validated in any of the previous studies.…”

Section: Discussionmentioning

confidence: 99%

The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer

Ledinek

Sobočan²,

Sisinger³

et al. 2023

Front. Oncol.

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Endometrial cancer is the most common gynecologic malignancy in the developed world. Risk stratification and treatment approaches are changing due to better understanding of tumor biology. Upregulated Wnt signaling plays an important role in cancer initiation and progression with promising potential for development of specific Wnt inhibitor therapy. One of the ways in which Wnt signaling contributes to progression of cancer, is by activating epithelial-to-mesenchymal transition (EMT) in tumor cells, causing the expression of mesenchymal markers, and enabling tumor cells to dissociate and migrate. This study analyzed the expression of Wnt signaling and EMT markers in endometrial cancer. Wnt signaling and EMT markers were significantly correlated with hormone receptors status in EC, but not with other clinico-pathological characteristics. Expression of Wnt antagonist, Dkk1 was significantly different between the ESGO-ESTRO-ESP patient risk assessment categories using integrated molecular risk assessment.

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Section: Discussionmentioning

confidence: 99%

The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer

Ledinek

Sobočan²,

Sisinger³

et al. 2023

Front. Oncol.

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“…(The CDH1 mutation analysis revealed a few such cases.) There are also publications reporting on decreased expression of E‐cadherin in nonlobular breast cancers and consequently diminished cell cohesion, epithelial mesenchymal transition—factors predisposing to form metastases 22,30,31 . Therefore, the distinction between NST carcinomas with loss of E‐cadherin staining (Figure 4) and nonclassical ILCs with aberrant or no staining may also not be obvious all the time.…”

Section: Discussionmentioning

confidence: 99%

“…Aberrant staining has also been used in connection with NST carcinomas, when the staining is diminished in intensity or at least partially lacking (Figure 4). 31 When a strong membranous staining is present, synchronous cytoplasmic reactions are generally ignored, or regarded as artefactual. Indeed, cytoplasmic staining may be artefactual; for example, with an excess of antibody, cytoplasmic staining may occur and with dilution it may vanish (Figure S7).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the routine use of E‐cadherin immunohistochemistry in the typing of breast carcinomas: results of a randomized diagnostic study

Cserni,

Kálmán,

Udvarhelyi

et al. 2023

Histopathology

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AimsInvasive lobular carcinoma (ILC) has distinct morphology and association with loss of E‐cadherin function. It has special clinical and imaging features, and its proper recognition is important. Following a recent proposal, we tested the value of the routine use of E‐cadherin immunohistochemistry (IHC) in recognizing ILC.Methods and resultsFive pathologists with experience in breast pathology from four Hungarian institutions histotyped 1001 breast cancers from diagnostic core biopsies or excision specimens randomly assigned to haematoxylin and eosin (HE) diagnosis first, followed by E‐cadherin IHC; or to immediate HE and E‐cadherin‐based diagnosis. Of 524 cases with HE diagnosis, 73(14%) were deemed uncertain. E‐cadherin made the initial histological type change in 14/524 cases (2.7%), including three with confident HE‐based type allocation. Use of E‐cadherin immunostaining was considered useful in 88/477 cases (18%) with immediate dual assessment, and typing uncertainty went down to 5% (25/477 cases), but was not zero. Collective assessment of 171 uncertain, difficult, nonclassical cases resulted in consensus diagnosis in most cases, but 15 cases were still doubtful as concerns their proper histological type. CDH1 gene sequencing was attempted and successful in 13; pathogenic genetic alterations were identified in seven cases.ConclusionsThe routine use of E‐cadherin IHC decreases the uncertainty in typing and improves the typing accuracy at the cost of potentially redundant additional immunostains. Furthermore, this procedure does not exclude uncertainty due to E‐cadherin‐positive ILCs, which are occasionally difficult to confidently label as ILC, especially when the growth pattern is not classic.

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Aldehyde dehydrogenase 1 expression in invasive breast carcinoma and its correlation with other clinicopathological parameters

Cited by 2 publications

References 29 publications

The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer

The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer

Evaluation of the routine use of E‐cadherin immunohistochemistry in the typing of breast carcinomas: results of a randomized diagnostic study

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