Alcoholysis of 1,3-Diketones

Scandium triflate catalyzed unexpected cleavage of C-C bonds in ynones

“…[19][20][21][22][23][24] However, such kind of C(sp)-C(sp) bond cleavage in ynones are remains uncommon 25 . Similarly, it should be noted that the such kind of cleavage in 1,3-diketone 26,27 has literature precedence; however, the use of naked H + , [28][29][30][31][32] amines 33 or strong bases [34][35] are necessary and the reactions are low yielding. 36 Despite these precedents, the catalytic cleavage of C-C bond in 1,3-diketones has, to date, not evolved into a synthetically useful methodology.…”