Alcoholism and smoking as a risk factor for late-onset Alzheimer's disease: A meta-analysis study

Abstract

Objective: to determine, using a systematic review of meta-analysis studies, whether or not, remote alcohol and smoke are significant risk factors for late-onset Alzheimer's disease. Methods: using a meta-analysis statistics model, 12 case-control studies (6 for alcohol /6 for smoke) published on Medline from 1984 until 1999 which evaluated the interaction between those factors and Alzheimer's disease were investigated. Mantel-Haenszel adjusted odds ratio (OR) and 95% confidence intervals were calculated in stratified data. Epi Info statistical software was used to determine p-value with significant level at 0.05. Results: the studies showed that a prior history of alcohol abuse wasn't associated with late-onset of dementia due to Alzheimer's disease (OR=0.98; 95%CI 0.63 to 1.52; and p-value=0.996). And the other studies showed that a prior history of tabagism wasn't considered as a risk factor for AD (OR=0.70; 95%CI 0.57 to 0.85; and p-value= 0.0004). Conclusions: In this study alcoholism wasn't considered as a risk factor for AD .On the other hand , in people who had the smoke habit, chances of late-onset Alzheimer's development were reduced in 30%. In that case, tabagism was considered as a protector factor for AD.

Verminoses em crianças e prevenção na perspectiva da educação em saúde: revisão narrativa, 2001 a 2020

“…A metodologia trata-se de uma revisão de literatura tipo narrativa, frequentemente utilizada em trabalhos acadêmicos, visto que tem como finalidade mapear o conhecimento sobre um conteúdo amplo, onde não há critérios sistemáticos ou explícitos fornecendo ao leitor Brazilian Journal of Health Review, Curitiba, v. 6, n. 2, p.5066-5079, mar./apr., 2023 conhecimento mais aprofundados sobre o trabalho a ser realizado e possibilitando a reflexão sobre o tema relacionando-o com os resultados obtidos por outros autores (FONTELLES, 2009). Em alguns casos, esta pesquisa pode ser chamada de "estado de arte", indicando a atenção com que os pesquisadores referem ao conteúdo, ao tema, subtemas e a todo o conteúdo pesquisado (ROMANOWSKI, 2006).…”