Alcoholic neuropathy associated with chronic alcohol intake

Tessitore, Maria Eduarda; Pereira-Rufino, Laís da Silva; Panfilio, Carlos Eduardo; Sinigaglia, Rita de Cássia; Júnior, Odair Aguiar; Maluf, Luciana Le-Sueur; Conte, Rafael; Ladd, Fernando Vagner Lobo; Céspedes, Isabel Cristina

doi:10.1016/j.ibneur.2022.08.004

Cited by 3 publications

(2 citation statements)

References 62 publications

(91 reference statements)

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“…To our knowledge, our study is the first to determine mechanical allodynia using von Frey filaments with the mouse CIE‐2BC paradigm in both sexes. Previous studies have mainly determined hyperalgesia in rats (Avegno et al, 2018; Dina et al, 2006; Edwards et al, 2020; Fu et al, 2021; Navarro et al, 2008; Pradhan et al, 2019; Roltsch Hellard et al, 2017; Tessitore et al, 2022). We found no sex differences between dependent male and female mice in the abstinence‐induced pain hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol‐evoked neuropathic pain

Borgonetti

Roberts

Bajo

et al. 2023

British J Pharmacology

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Background and Purpose. Unrelieved chronic pain is considered a key factor contributing to the maintenance of alcohol use disorder (AUD). The mechanisms responsible for chronic pain associated with chronic alcohol consumption are still unknown. Thus, our goal was to evaluate the development of chronic pain in a mouse model of alcohol dependence and investigate the role of neuroinflammation in this chronic condition. Experimental Approach. We used the chronic-intermittent ethanol two-bottle choice CIE-2BC paradigm that generates three groups: (1) alcohol-dependent mice that exhibit escalating alcohol intake,(2) nondependent mice, mimicking moderate drinking, that experience voluntary drinking, and (3) alcohol-naïve control male and female mice. We measured mechanical allodynia using von Frey filaments during withdrawal and after the last voluntary drinking. Finally, we used immunoblotting to evaluate the protein levels of ionized calcium-binding adapter molecule-1 (IBA-1), macrophage-colony stimulating factor (CSF-1), interleukin 6 (IL-6), p38 and extracellular signal-regulated kinase 1/2 (ERK44/42) in spinal cord tissue of dependent and non-dependent animals. Key Results. We found significant escalation of drinking in the dependent group in male and female compared with the non-dependent group. The dependent group developed strong mechanical allodynia during 72 h of withdrawal, which was completely reversed immediately after the voluntary drinking. Moreover, we observed an increased pain hypersensitivity (allodynia) compared with the naïve group in 40% and 50% of non-dependent male and female mice, respectively. Increased IBA-1 and CSF-1 expression was observed in spinal cord tissue of both hypersensitivity-abstinence related and neuropathy-alcohol mice, and increased IL-6 expression and ERK44/42 activation in mice with hypersensitivity-related to abstinence, but not in mice with alcohol-evoked neuropathic pain. Conclusions and Implications. We showed that the CIE-2BC model induces two distinct pain conditions specific to the type of ethanol exposure: abstinence-related

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Section: Discussionmentioning

confidence: 99%

Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol‐evoked neuropathic pain

Borgonetti

Roberts

Bajo

et al. 2023

British J Pharmacology

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“…Клиническая картина включает потерю чувствительности в стопах и снижение (или отсутствие) рефлексов. Прогрессирование болезни продолжается несколько месяцев и проявляется нарушением походки, симметричной жгучей болью и онемением в ногах, к которому присоединяется слабость в мышцах ног [32].…”

Section: Note Alc -Amyotrophic Lateral Sclerosis; Dspk -Degenerative ...unclassified

Neurological disorders imitating spinal stenosis in elderly patients. Series of clinical observations

Seliverstova,

Kordonskiy,

Druzhinina

et al. 2023

Nejrohirurgiâ (Mosk.)

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Spinal stenosis is a pathological narrowing of the central spinal canal, lateral pocket, or intervertebral foramen due to age‑related changes, including pathology of the discs, facet joints, ligament hypertrophy, osteophyte formation and destruction of the arches. Clinically, the disease can manifest itself with pain, as well as numbness, or weakness in the arms or legs. The complexity of differential diagnosis is due to the lack of correlation between the degree of stenosis according to neuroimaging data and the severity of clinical manifestations. Spinal stenosis among 21 % of people may have an asymptomatic course.Spinal stenosis has to be differentiated from atherosclerosis of the vessels of the lower extremities, rheumatoid arthritis, piriformis syndrome, sacroiliitis, spondylitis/spondylodiscitis, amyotrophic lateral sclerosis, Guillain–Barré syndrome and other polyneuropathies. Isolated weakness should be of a particular concern in the clinical picture. Muscle hypotrophy, brisk tendon reflexes, the presence of pyramidal signs, muscle fasciculations, as well as patients’ complaints of simultaneous weakness in both the upper and lower extremities accompany them.We present and discuss three clinical cases of patients with a presumptive diagnosis of spinal stenosis. Two of them were held surgical treatment, which did not produce the expected result. Subsequently, it was found that the cause of progressive muscle weakness in the limbs was amyotrophic lateral sclerosis in two patients and the third one had Guillain–Barré syndrome, a form of acute demyelinating polyneuropathy.

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Late diagnosis of chronic inflammatory demyelinating polyneuropathy on the background of misdiagnosed alcoholic polyneuropathy: a clinical case

Shtaimets,

Mineeva,

Lalov

et al. 2024

Medicinskij alfavit

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Chronic inflammatory demyelinating polyneuropathy is a rare immune-mediated polyneuropathy pathology of the peripheral nervous system. The presence of etiological factors in the patient, such as type 1 and 2 diabetes mellitus, alcohol intoxication in the anamnesis or other causes of polyneuropathy, which are often found in practice, can disguise chronic inflammatory demyelinating polyneuropathy and lead to delayed diagnosis of potentially curable polyneuropathy, which further increases the likelihood of disability of the patient and a significant decrease in the quality of his life. The clinical case under consideration is a demonstration of such diagnostic difficulties, which led to a delayed diagnosis of chronic inflammatory demyelinating polyneuropathy against the background of alcohol abuse in the debut of neurological disorders.

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Alcoholic neuropathy associated with chronic alcohol intake

Cited by 3 publications

References 62 publications

Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol‐evoked neuropathic pain

Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol‐evoked neuropathic pain

Neurological disorders imitating spinal stenosis in elderly patients. Series of clinical observations

Late diagnosis of chronic inflammatory demyelinating polyneuropathy on the background of misdiagnosed alcoholic polyneuropathy: a clinical case

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