Alcoholic drinks: Important triggers for asthma

Vally, Hassan; Klerk, Nicholas de; Thompson, Philip J.

doi:10.1067/mai.2000.104548

Cited by 106 publications

(108 citation statements)

References 16 publications

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“…Limitations of this study were the high fraction of atopic asthmatics (84%), the exclusion of mild asthmatics, the high proportions of males (63%) and the inability to determine the prevalence of alcohol consumption among asthmatics. These findings were validated in a larger study that also identified sulfite additives and even salicylates in wines as triggers for asthma (Vally et al, 2000). The important findings from these studies are that: 1) the non-alcohol congeners present in different alcoholic beverages may act as triggers for asthma; and 2) alcohol may, in some asthmatics, act as a bronchodilator.…”

Section: Clinical Studies Of Alcohol and Asthmamentioning

confidence: 68%

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Alcohol and airways function in health and disease

Sisson

2007

Alcohol

135

136

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The volatility of alcohol promotes the movement of alcohol from the bronchial circulation across the airway epithelium and into the conducting airways of the lung. The exposure of the airways through this route likely accounts for many of the biologic effects of alcohol on lung airway functions. The impact of alcohol on lung airway functions is dependent on the concentration, duration and route of exposure. Brief exposure to mild concentrations of alcohol may enhance mucociliary clearance, stimulates bronchodilation and probably attenuates the airway inflammation and injury observed in asthma and COPD. Prolonged and heavy exposure to alcohol impairs mucociliary clearance, may complicate asthma management and likely worsens outcomes including lung function and mortality in COPD patients. Non-alcohol congeners and alcohol metabolites act as triggers for airway disease exacerbations especially in atopic asthmatics and in Asian populations who have a reduced capacity to metabolize alcohol. Research focused on the mechanisms of alcohol-mediated changes in airway functions has identified specific mechanisms that mediate alcohol effects within the lung airways. These include prominent roles for the second messengers calcium and nitric oxide, regulatory kinases including PKG and PKA, alcohol and acetaldehyde-metabolizing enzymes such as aldehyde dehydrogenase type 2 (ALDH2). The role alcohol may play in the pathobiology of airway mucus, bronchial blood flow, airway smooth muscle regulation and the interaction with other airway exposure agents, such as cigarette smoke, represent opportunities for future investigation.

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Section: Clinical Studies Of Alcohol and Asthmamentioning

confidence: 68%

“…These studies indicate that both the purity (pure ethanol vs. an alcoholic beverage) and the route (oral vs. intravenous) are factors that may determine how alcohol might modify airway function. An excellent review of alcoholic drinks as triggers for asthma has been previously published (Vally et al, 2000).…”

Section: Clinical Studies Of Alcohol and Asthmamentioning

confidence: 99%

Alcohol and airways function in health and disease

Sisson

2007

Alcohol

135

136

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“…Wine is an important source of flavonoids, which could plausibly reduce asthma inflammation through antioxidant, antiallergic and antiinflammatory properties [23]. Besides flavonoids, alcohol itself may have a modest bronchodilator effect and is likely to relax bronchial smooth muscle [24]. Nevertheless, reverse causation cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns and asthma in the E3N study

Varraso¹,

Kauffmann²,

Leynaert³

et al. 2009

European Respiratory Journal

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The aim of the present study was to determine dietary patterns and investigate their association with asthma incidence, current asthma and frequent asthma exacerbations.Dietary habits and asthma data were collected from the large E3N study (of French females, mostly teachers). Of the 54,672 females followed-up in 2003, 2,634 reported ever-adulthood asthma, 1,063 reported current asthma, 206 reported frequent asthma attacks (one or more a week), and 628 reported asthma onset between 1993 and 2003. Using principal component analysis, three dietary patterns were identified: the ''prudent'' pattern (fruits and vegetables); the ''Western'' pattern (pizza/salty pies, dessert and cured meats); and the ''nuts and wine'' pattern. Pattern scores were categorised into tertiles, and the incidence and prevalence of asthma was compared between tertiles.After adjustment for confounders, no association of dietary patterns was observed with asthma incidence, ever-asthma or current asthma. The Western pattern was associated with an increased risk of reporting frequent asthma attacks (highest versus lowest tertile odds ratio (OR) 1.79, 95% confidence interval (CI) 1.11-3.73). Increasing scores of the nuts and wine pattern were associated with a decreased risk of reporting frequent asthma attacks (highest versus lowest tertile OR 0.65, 95% CI 0.31-0.96).The results of the present study suggest that overall diet could be involved in frequent asthma exacerbations, one aspect of asthma severity.

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“…In asthmatic patients, asthma symptoms are sometimes worsened after alcohol consumption [64]. A cohort study has reported that sulfite in wine triggers asthmatic reactions [65]. Very little is known about the mechanisms involved in these reactions.…”

Section: Discussionmentioning

confidence: 99%