Alcoholic diabetes. Induction of glucose intolerance with alcohol

Determinants of glycated haemoglobin in the general population: associations with diet, alcohol and cigarette smoking

“…Laws et al (1990) found that cigarette smoking was associated with greater truncal obesity, but the association of GHb with smoking was independent of waist ± hip circumference ratio. Reports of the association between consumption of alcohol and risk of type 2 diabetes have given con¯icting results (Rewers & Hamman, 1995;Balkau et al, 1991;Wei et al, 2000;Perry et al, 1995;Rimm et al, 1995;Stampfer et al, 1998;Phillips & Safrit, 1971;Holbrook et al, 1990). The present results suggest an inverse association between alcohol consumption and GHb in the general population.…”

The Relationship Between Chronic Alcohol Use and Type 2 Diabetes Mellitus: New Insights into Mechanisms of Appetite-Regulating Peptides

“…The association between alcohol consumption and DM was demonstrated early in 1971 by Phillips et al [41]. This study suggested that alcohol with doses of 266 to 513 ml produced glucose intolerance and insulin resistance in three of six healthy subjects.…”

“…Most directly, alcohol can induce acute and chronic pancreatitis and result in DM as in T1DM [59]. However, there is a growing body of evidence suggesting that the diabetogenic effect of alcohol does not seem to be mediated by decreased insulin secretion [41]. The priming effect of ethanol-enhanced insulin secretion in pancreatic -cells might be caused by an early defence mechanism used to compensate for alcohol-inhibited basal insulin secretion.…”

Role of substrate competition in the pathogenesis of insulin resistance in man

“…Moreover, it has been reported that severe ethanol intoxication may be responsible for the development of acute reversible forms of diabetes (36). It has been proposed that ethanol-induced inhibition of insulin secretion is the mechanism at the origin of diabetes in this setting.…”