Alcoholic chronic pancreatitis and liver cirrhosis: Coincidence and differences in lifestyle

Špičák, Julius; Pulkertova, Adela; Králová-Lesná, Ivana; Suchánek, Pavel; Vitásková, Martina; Adámková, Věra

doi:10.1016/j.pan.2012.05.008

Cited by 14 publications

(12 citation statements)

References 18 publications

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“…The two major causes of chronic liver disease in patients with ACP are alcohol abuse and/or compression of the biliary duct [1,3,[9][10][11]36]. Cholestasis due to the fibrous pancreatic head was an exclusion criterion in our study, and therefore only the toxic etiology of the liver injury was assessed.…”

Section: Discussionmentioning

confidence: 99%

“…ACP has been found to be more common in patients who smoke, have a long-term history of alcohol consumption, and prefer to drink spirits, and have a relatively low level of education [9], whereas ALF was reported to be more frequent in smokers [1]. The duration of chronic alcohol abuse proved to be shorter in ACP than in ALF, and cirrhosis was more characteristic among older subjects [3,10].…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Zsóri¹,

Czepán²,

Illés³

et al. 2017

Pancreat Disord Ther

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Objective: The coincidence of chronic pancreatitis and liver cirrhosis in alcoholic patients is comparatively rare. Our aim was to assess liver fibrosis in patients with alcoholic chronic pancreatitis (ACP) by measuring noninvasive fibrosis scores and liver stiffness. Methods:Fifty-five patients with ACP were enrolled in the study. Eight healthy volunteers served as controls. Noninvasive fibrosis scoring systems, including the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 score (FIB-4), were determined and transient elastography (TE) was performed.Results: Mild (F1 or F2) and severe (F3 or F4) fibrosis was revealed by TE in 15 and 6 patients (38.2%), respectively. However, the levels of the liver enzymes were elevated in only 12 patients. The APRI and FIB-4 scores jointly revealed fibrosis of the liver in two patient. ACP patients with liver fibrosis drank significantly more amount of alcohol and had diabetes more frequently than ACP patients without liver fibrosis. Conclusion:Liver fibrosis was revealed by TE in one-fourth of the ACP patients. Liver enzymes are not reliable parameters with which to diagnose liver fibrosis. The quantity of consumed alcohol and the presence of DM are risk factors for the development of liver fibrosis in ACP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Zsóri¹,

Czepán²,

Illés³

et al. 2017

Pancreat Disord Ther

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“…Although chronic pancreatitis (CP) and liver cirrhosis (LC) are quite frequent gastroenterological disorders that share common risk factors, the co-incidence of both diseases is considered to be rare [1,2]. Clinical studies reported a co-incidence of cirrhosis in around 12.5e17.0% of patients with CP [3,4] and a co-incidence of CP of 6.6e16.0% in patients with LC [1,3,5]. Mostly alcoholism was an underlying etiologic factor [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Clinical studies reported a co-incidence of cirrhosis in around 12.5e17.0% of patients with CP [3,4] and a co-incidence of CP of 6.6e16.0% in patients with LC [1,3,5]. Mostly alcoholism was an underlying etiologic factor [1,3,4]. Some studies with smaller patient numbers showed an even higher association of both diseases with up to 38% concomitant chronic pancreatitis in liver cirrhotics [5,6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of lifestyle factors in patients with concomitant chronic pancreatitis and liver cirrhosis

et al. 2017

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“…Alcohol consumption is the world's third largest risk factor for disease and disability and is considered to cause epilepsy, liver cirrhosis, pancreatitis, angiocardiopathy and several types of cancer [3][4][5][6] . Currently, there are only three FDA-approved medications available for the treatment of alcohol dependence, disulfiram, naltrexone and acamprosate.…”

Section: Introductionmentioning

confidence: 99%

Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats

Liu

Gong

et al. 2014

Acta Pharmacol Sin

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Aim: Brucine (BRU) extracted from the seeds of Strychnos nux-vomica L is glycine receptor antagonist. We hypothesize that BRU may modify alcohol consumption by acting at glycine receptors, and evaluated the pharmacodynamic profiles and adverse effects of BRU in rat models of alcohol abuse. Methods: Alcohol-preferring Fawn-Hooded (FH/Wjd) rats were administered BRU (10, 20 or 30 mg/kg, sc). The effects of BRU on alcohol consumption were examined in ethanol 2-bottle-choice drinking paradigm, ethanol/sucrose operant self-administration paradigm and 5-d ethanol deprivation test. In addition, open field test was used to assess the general locomotor activity of FH/Wjd rats, and conditioned place preference (CPP) was conducted to assess conditioned reinforcing effect. Results: In ethanol 2-bottle-choice drinking paradigm, treatment with BRU for 10 consecutive days dose-dependently decreased the ethanol intake associated with a compensatory increase of water intake, but unchanged the daily total fluid intake and body weight. In ethanol/sucrose operant self-administration paradigms, BRU (30 mg/kg) administered before each testing session significantly decreased the number of lever presses for ethanol and the ethanol intake, without affecting the number of sucrose (10%) responses, total sucrose intake, and the number of lever presses for water. Acute treatment with BRU (30 mg/kg) completely suppressed the deprivation-induced elevation of ethanol consumption. Treatment with BRU (10, 20, and 30 mg/kg) did not alter locomotion of FH/Wjd rats, nor did it produce place preference or aversion. Conclusion: BRU selectively decreases ethanol consumption with minimal adverse effects. Therefore, BRU may represent a new pharmacotherapy for alcoholism.

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Alcoholic chronic pancreatitis and liver cirrhosis: Coincidence and differences in lifestyle

Cited by 14 publications

References 18 publications

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Analysis of lifestyle factors in patients with concomitant chronic pancreatitis and liver cirrhosis

Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats

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