Alcoholic beverage consumption and gastric cancer risk: A prospective population‐based study in women

Larsson, Susanna C.; Giovannucci, Edward; Wolk, Alicja

doi:10.1002/ijc.22204

Cited by 29 publications

(17 citation statements)

References 47 publications

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“…The risk of gastric cancer was significantly decreased in our study, which supported our hypothesis. Some previous studies found that the risk of gastric cancer was not associated with alcohol consumption or was associated positively with alcohol consumption (Larsson et al, 2007;Sung et al, 2007;IARC, 2010;Duell et al, 2011), which contradicts our observation. However, most of the previous studies defined alcohol consumption and gastric cancer on the basis of self-answered questionnaires, with possible reporting bias.…”

Section: Discussioncontrasting

confidence: 85%

“…It is thus necessary to examine whether alcohol consumption is associated with adenocarcinoma in the esophagus. The current evidence suggests that the association between alcohol consumption and gastric cancer is unclear (Larsson et al, 2007;Sung et al, 2007;IARC 2010;Duell et al, 2011). It is known that Helicobacter pylori infection is causally linked to gastric cancer (De Koster et al, 1994;Hohenberger and Gretschel, 2003), which may partly explain the continuous decrease in the incidence of gastric cancer with the decreased prevalence of H. pylori.…”

Section: Introductionmentioning

confidence: 96%

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Associations of alcohol use disorders with esophageal and gastric cancers: a population-based study in Sweden

Sundquist

2017

European Journal of Cancer Prevention

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Alcohol consumption is associated with squamous cell carcinoma of the esophagus, but little is known about whether alcohol consumption is associated with adenocarcinoma of the esophagus and gastric cancer, which we attempt to clarify in this study. Individuals with alcohol use disorders were identified from the nation-wide Swedish Hospital Discharge Register and Outpatient Register, the Crime Register, and the Prescription Drug Register, and they were linked to the Swedish Cancer Registry to calculate standardized incidence ratios of esophageal and gastric cancers using those without alcohol use disorders (AUDs) as a reference. A total of 14 518 and 73 504 patients were diagnosed with esophageal and gastric cancers, separately, during the study period. The risk of esophageal cancer was significantly increased, with a standardized incidence ratio of 2.24 (95% confidence interval 2.08-2.41) among individuals with AUDs. Both squamous cell carcinoma and adenocarcinoma of the esophagus were increased (2.89 for squamous cell carcinoma and 1.20 for adenocarcinoma). The incidence of gastric cancer was significantly decreased and the decrease was even more prominant for corpus cancer compared with cardia cancer (0.57 vs. 0.82). In this retrospective cohort study, we found that AUDs were associated with an increased risk of both squamous cell carcinoma and adenocarcinoma of the esophagus, whereas individuals with AUDs had a lower risk of gastric cancer, especially for corpus cancer, which may be related to the eradication of Helicobacter pylori infection. However, the underlying mechanisms need to be explored in future studies.

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Section: Discussioncontrasting

confidence: 85%

Section: Introductionmentioning

confidence: 96%

Associations of alcohol use disorders with esophageal and gastric cancers: a population-based study in Sweden

Sundquist

2017

European Journal of Cancer Prevention

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“…Although it is generally agreed that light to moderate alcohol consumption is inversely correlated with CV risk, 13,14 our findings should not be used to promote alcohol consumption as a CV preventive strategy because alcohol has also several other adverse health consequences such as cancer and injuries. 15,16 …”

Section: Discussionmentioning

confidence: 99%

Impact of Sex on Cardiovascular Outcome in Patients at High Cardiovascular Risk

et al. 2012

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Background-Epidemiological data suggest that sex independently contributes to cardiovascular risk. Clinical trials are often hampered by the enrollment of few female patients. Methods and Results-The Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial(ONTARGET) and the parallel Telmisartan Randomized Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease (TRANSCEND) included a large proportion of female patients (9378 female versus 22 168 male patients). Differences in male and female patients enrolled in ONTARGET/TRANSCEND were analyzed for the primary 4-fold end point (composite of cardiovascular death, myocardial infarction, stroke, or admission to hospital for heart failure), a secondary 3-fold end point (cardiovascular death, myocardial infarction, stroke), and individual components of the primary composite. Baseline characteristics included age, ethnicity, body mass index, physical activity, tobacco use, alcohol consumption, formal education, clinical diagnosis for study entry, patient history, and concomitant medication. Patients were followed up until death or the end of the study (median, 56 months). Compared with male patients, female patients had a 19% significantly lower risk for the 4-fold end point and 21% for the 3-fold end point (after adjustment for study, treatment, and the above baseline values). Similarly, the adjusted risk for cardiovascular death (17%) and myocardial infarction (22%), but not for stroke and hospitalization for heart failure, was also significantly lower in women. Diabetic female patients were characterized by a higher risk for acute myocardial infarction compared with diabetic male patients, whereas alcohol consumption resulted in significantly lower risk in women. Conclusions-In our analysis made up of 70.3% male and 29.7% female patients, an Ϸ20% lower risk for the combined cardiovascular end points in female patients was observed despite treatment with cardioprotective agents. This difference was driven primarily by a significantly lower incidence of myocardial infarction. Thus, we demonstrate in a large interventional trial that sex greatly affects the occurrence of cardiovascular events in patients with vascular disease or high-risk diabetes mellitus. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00153101.

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“…Similar efforts have been directed at developing harmonized alcohol-consumption measures for studies of cancer (50). Alcohol intake data collected by using various foodfrequency questionnaires tend to correlate highly (51,52). However, reducing measurement heterogeneity within a set of studies with a common theme (eg, alcohol and cancer) does not ensure that these alcohol measures can themselves be combined with alcohol use assessed in studies focused on other endpoints, ie, if one is interested in identifying the genetic underpinnings of alcohol consumption, variations in the alcohol measures presented in Table 1 may still pose a challenge.…”

Section: Why Measurement Heterogeneity Occursmentioning

confidence: 99%

Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges

Agrawal¹,

Freedman²,

Cheng³

et al. 2012

The American Journal of Clinical Nutrition

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Whereas moderate drinking may have health benefits, excessive alcohol consumption causes many important acute and chronic diseases and is the third leading contributor to preventable death in the United States. Twin studies suggest that alcohol-consumption patterns are heritable (50%); however, multiple genetic variants of modest effect size are likely to contribute to this heritable variation. Genome-wide association studies provide a tool for discovering genetic loci that contribute to variations in alcohol consumption. Opportunities exist to identify susceptibility loci with modest effect by meta-analyzing together multiple studies. However, existing studies assessed many different aspects of alcohol use, such as typical compared with heavy drinking, and these different assessments can be difficult to reconcile. In addition, many studies lack the ability to distinguish between lifetime and recent abstention or to assess the pattern of drinking during the week, and a variety of such concerns surround the appropriateness of developing a common summary measure of alcohol intake. Combining such measures of alcohol intake can cause heterogeneity and exposure misclassification, cause a reduction in power, and affect the magnitude of genetic association signals. In this review, we discuss the challenges associated with harmonizing alcohol-consumption data from studies with widely different assessment instruments, with a particular focus on large-scale genetic studies.Am J Clin Nutr 2012;95:539-47.

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Alcoholic beverage consumption and gastric cancer risk: A prospective population‐based study in women

Cited by 29 publications

References 47 publications

Associations of alcohol use disorders with esophageal and gastric cancers: a population-based study in Sweden

Associations of alcohol use disorders with esophageal and gastric cancers: a population-based study in Sweden

Impact of Sex on Cardiovascular Outcome in Patients at High Cardiovascular Risk

Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges

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