Alcohol use disorders in multidrug resistant tuberculosis MDR-TB patients and their non-tuberculosis family contacts in Nigeria

Lasebikan, Victor Olufolahan; Ige, Olusoji Mayowa

doi:10.11604/pamj.2020.36.321.17118

Cited by 5 publications

(8 citation statements)

References 32 publications

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Section: Resultsmentioning

confidence: 99%

“…The lung cavity plays a role in the occurrence of MDR-TB, because it is related to the extent of the cavity in the parenchyma with the longer time of sputum conversion. Lung cavities are established risk factors for extending the time that it takes for a culture to convert, as well as conditions that can lead to treatment failure [10], [13]. Malnutrition is known to produce a decline in the body's immunity, increasing susceptibility to MDR-TB.…”

Section: Resultsmentioning

confidence: 99%

“…Malnutrition is known to produce a decline in the body's immunity, increasing susceptibility to MDR-TB. Nutritional deficiency weakens a person's immune system, making sickness more likely [13].…”

Section: Resultsmentioning

confidence: 99%

“…Other studies have discovered a link between MDR-TB and alcohol consumption, working status, and educational level [11], [13], [14], [15]. People who use alcohol have a lower immune system, making them more vulnerable to MDR-TB [13]. Furthermore, patients who work will forget to take their TB medications as a result of their work activities [14].…”

Section: Resultsmentioning

confidence: 99%

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Factors Associated of Multidrug-Resistance Tuberculosis among Minangkabau Ethnicity in Indonesia

Kadri

Machmud

Putra

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Past tuberculosis therapy has been linked to an increased chance of developing multidrug-resistant tuberculosis (MDR-TB). Indonesia is placed 8th among the 27 nations with "high-burden" MDR-TB. AIM: The purpose of this study was to determine the risk factors associated of multidrug-resistance tuberculosis among minangkabau ethnicity in Indonesia. METHODS: The authors conducted a case control study. Data were gathered in Dr. M Djamil General Hospital Padang, Lubuk Alung Hospital Pariaman and Primary Health Care in Padang Pariaman District from December 2019-March 2020. In this study, there were 73 cases (MDR-TB) and 219 controls (Tuberculosis) who were matched by age and sex. The sampling technique in this research was convenience sampling. Data were gathered from medical records. Bivariate and multivariate analysis were investigated using chi-square and logistic binary regression test. The data were analyzed using STATA version 14.2. Results: The risk factors for MDR-TB, cavitary pulmonary had the highest odds ratio (OR = 113.54 [95% CI 15.02-858.54]), followed by TB outside the lung (OR = 38,68 [95% CI 4.89-305.43]), nutritional status (OR = 10.92 [95% CI 5.79-20.56]), alcohol consumption (OR = 6.45 [95% CI 1.57-26.48]), working status (OR = 4.08 [95% CI 2.33-7.17]), level of education (OR = 2.79 [95% CI 1.61-4.85]), history of close contact to patients with MDR-TB and TB (OR = 2.35 [95% CI 1.30-4.22]) and diabetes mellitus (OR = 2.12 [95% CI 1.15-3.91]). Multivariate analysis found that patients with a cavitary pulmonary was significant dominant factors for MDR-TB. Conclusion: MDR-TB was predicted by previous tuberculosis therapy and cavitary pulmonary disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Factors Associated of Multidrug-Resistance Tuberculosis among Minangkabau Ethnicity in Indonesia

Kadri

Machmud

Putra

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…For example, it is known that AUD has been associated with delays in accessing TB care and poor adherence to TB treatment, both of which may contribute to the more advanced, severe disease at the time of diagnosis and inadequate therapy ( 44 , 45 ). More recent data indicate an increased incidence of multi-drug resistant TB in people with AUD, possibly due to poor treatment adherence as well as comorbidities associated with AUD that impact immune function and metabolism ( 43 , 46 , 47 ). However, as described above, poor TB outcomes persist among individuals with AUD even when controlling for behaviors that impact access to and retention in treatment (e.g., individuals with AUD lost to treatment follow-up) ( 28 ).…”

Section: Alcohol and Tb Epidemiologymentioning

confidence: 99%

The Impact of Alcohol Use Disorder on Tuberculosis: A Review of the Epidemiology and Potential Immunologic Mechanisms

et al. 2022

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Globally, an estimated 107 million people have an alcohol use disorder (AUD) leading to 2.8 million premature deaths each year. Tuberculosis (TB) is one of the leading causes of death globally and over 8% of global TB cases are estimated to be attributable to AUD. Social determinants of health such as poverty and undernutrition are often shared among those with AUD and TB and could explain the epidemiologic association between them. However, recent studies suggest that these shared risk factors do not fully account for the increased risk of TB in people with AUD. In fact, AUD has been shown to be an independent risk factor for TB, with a linear increase in the risk for TB with increasing alcohol consumption. While few studies have focused on potential biological mechanisms underlying the link between AUD and TB, substantial overlap exists between the effects of alcohol on lung immunity and the mechanisms exploited by Mycobacterium tuberculosis (Mtb) to establish infection. Alcohol misuse impairs the immune functions of the alveolar macrophage, the resident innate immune effector in the lung and the first line of defense against Mtb in the lower respiratory tract. Chronic alcohol ingestion also increases oxidative stress in the alveolar space, which could in turn facilitate Mtb growth. In this manuscript, we review the epidemiologic data that links AUD to TB. We discuss the existing literature on the potential mechanisms by which alcohol increases the risk of TB and review the known effects of alcohol ingestion on lung immunity to elucidate other mechanisms that Mtb may exploit. A more in-depth understanding of the link between AUD and TB will facilitate the development of dual-disease interventions and host-directed therapies to improve lung health and long-term outcomes of TB.

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Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household

Kim

Hesseling²,

Wu³

et al. 2023

PLoS ONE

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Background Understanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting contact investigations. Methods Using data from a cross-sectional study that enrolled index participants with rifampin-resistant pulmonary TB and their household contacts (HHCs), we evaluated HHCs age ≥15 years for factors associated with two outcomes: Mycobacterium tuberculosis infection and TB disease. Among HHCs who were not already diagnosed with current active TB disease by the TB program, Mycobacterium tuberculosis infection was determined by interferon-gamma release assay (IGRA). TB disease was adjudicated centrally. We fitted logistic regression models using generalized estimating equations. Results Seven hundred twelve HHCs age ≥15 years enrolled from 279 households in eight high-TB burden countries were a median age of 34 years, 63% female, 22% current smokers and 8% previous smokers, 8% HIV-positive, and 11% previously treated for TB. Of 686 with determinate IGRA results, 471 tested IGRA positive (prevalence 68.8% (95% Confidence Interval: 64.6%, 72.8%)). Multivariable modeling showed IGRA positivity was more common in HHCs aged 25–49 years; reporting prior TB treatment; reporting incarceration, substance use, and/or a period of daily alcohol use in the past 12 months; sharing a sleeping room or more evenings spent with the index participant; living with smokers; or living in a home of materials typical of low socioeconomic status. Forty-six (6.5% (95% Confidence Interval: 4.6%, 9.0%)) HHCs age ≥15 years had prevalent TB disease. Multivariable modeling showed higher prevalence of TB disease among HHCs aged ≥50 years; reporting current or previous smoking; reporting a period of daily alcohol use in the past 12 months; and reporting prior TB treatment. Conclusion We identified overlapping and distinct characteristics associated with Mycobacterium tuberculosis infection and TB disease that may be useful for those conducting household TB investigations.

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Alcohol use disorders in multidrug resistant tuberculosis MDR-TB patients and their non-tuberculosis family contacts in Nigeria

Cited by 5 publications

References 32 publications

Factors Associated of Multidrug-Resistance Tuberculosis among Minangkabau Ethnicity in Indonesia

Factors Associated of Multidrug-Resistance Tuberculosis among Minangkabau Ethnicity in Indonesia

The Impact of Alcohol Use Disorder on Tuberculosis: A Review of the Epidemiology and Potential Immunologic Mechanisms

Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household

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