Alcohol Use and Treatment of Hepatitis C Virus: Results of a National Multicenter Study

Anand, B S; Currie, Sue; Dieperink, Eric; Bini, Edmund J.; Shen, Hui; Ho, Samuel B.; Wright, Teresa L.

doi:10.1053/j.gastro.2006.02.023

Cited by 142 publications

(120 citation statements)

References 30 publications

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“…More recent data, however, clearly suggest that the poor response of alcoholics towards interferon therapy is more likely due to reduced compliance. In this study, the recorded alcohol consumption during the months before HCV treatment was associated with an increased rate of therapy drop out (3% vs 26%, P = 0.002) [25] while the response rate was comparable (25% vs 23%) after correction for this confounding factor. In conclusion, poor compliance of alcoholics is probably the major cause for poor antiviral response to HCV therapy.…”

Section: Alcohol Consumption Hcv Replication and Response To Hcv Thementioning

confidence: 56%

Evaluation of standard liver volume formulae for Chinese adults

Shi¹,

Yan²,

Li³

et al. 2009

WJG

105

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Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs.

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Section: Alcohol Consumption Hcv Replication and Response To Hcv Thementioning

confidence: 56%

Evaluation of standard liver volume formulae for Chinese adults

Shi¹,

Yan²,

Li³

et al. 2009

WJG

105

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“…Pentoxifylline is an oral phosphodiesterase inhibitor which decreases expression of TNF-α (and other proinflammatory cytokines) and which may inhibit apoptosis. When the full course is completed, the SVR is similar, regardless of alcohol intake [45] .…”

Section: Alcohol Abusementioning

confidence: 98%

Hepatitis C comorbidities affecting the course and response to therapy

El-Zayadi¹

2009

WJG

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Several studies have demonstrated that the outcome of chronic hepatitis C (CHC) infection is profoundly influenced by a variety of comorbidities. Many of these comorbidities have a significant influence on the response to antiviral therapy. These comorbidities negatively affect the course and outcome of liver disease, often reducing the chance of achieving a sustained virological response with PEGylated interferon and ribavirin treatments. Comorbidities affecting response to antiviral therapy reduce compliance and adherence to inadequate doses of therapy. The most important comorbidities affecting the course of CHC include hepatitis B virus coinfection, metabolic syndrome, and intestinal bacterial overgrowth. Comorbidities affecting the course and response to therapy include schistosomiasis, iron overload, alcohol abuse, and excessive smoking. Comorbidities affecting response to antiviral therapy include depression, anemia, cardiovascular disease, and renal failure.

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“…Generally, patients should be encouraged to abstain from alcohol while on therapy since alcohol is assumed to impair outcome [31].…”

Section: Treatment Of Chronic Hepatitis C: Treatment Naïve Patientsmentioning

confidence: 99%

Treatment of hepatitis C virus infection: Updated Swedish Consensus recommendations

Lagging

Wejstål

Uhnoo

et al. 2009

Scandinavian Journal of Infectious Diseases

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Alcohol Use and Treatment of Hepatitis C Virus: Results of a National Multicenter Study

Cited by 142 publications

References 30 publications

Evaluation of standard liver volume formulae for Chinese adults

Evaluation of standard liver volume formulae for Chinese adults

Hepatitis C comorbidities affecting the course and response to therapy

Treatment of hepatitis C virus infection: Updated Swedish Consensus recommendations

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