Alcohol use and fasting glucose in a developing southern Chinese population: the Guangzhou Biobank Cohort Study

Schooling, CM; Jiang, Chao Qiang; Lam, Tai Hing; Zhang, W S; Cheng, Kar Keung; Leung, Gabriel M.

doi:10.1136/jech.2008.077602

Cited by 19 publications

(19 citation statements)

References 33 publications

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“…Recently, the views about protective effects of moderate alcohol consumption on healthy consequence have also been questioned. Several cohort studies have demonstrated that moderate alcohol use is not beneficial for heart function via QT interval or heart rate in men[21], but associated with higher fasting glucose[22]as well as increased alcohol related cancers in women[23]. In our study, long-term drinking (≥ 35 years)even with alleged moderate rang (80–210 g/week), was still a risk factor for NAFLD in elder men (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men

Liu¹,

Xu²,

Tang³

et al. 2017

PLoS ONE

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BackgroundWhether cigarette smoking and moderate drinking are associated with non-alcoholic fatty liver disease (NAFLD)has not been fully described. This study investigated the separate and joint effects of smoking and moderate drinking on Chinese men with NAFLD.MethodsAcross-sectional assay from DFTJ Cohort study was performed with a size of 9432 elderly Chinese men excluding excessive alcohol consumption (<210g/week). Fatty liver was diagnosed by standardized ultrasonographic inspection. The odds ratio (OR) of alcohol consumption and smoking for the prevalence of NAFLD were analyzed using multiple logistic regression with multiple adjustments.ResultsThe prevalence of NAFLD in current smokers (pack-year≥40) and drinkers (80~210g/week or drinking duration≥35years) was significantly higher than that in non-smokers and non-drinkers, respectively. The combination of current smoking (pack-year≥40) and drinking (80~210g/week) was associated with the highest risk of NAFLD (OR 1.85; 95% confidence interval [CI] 1.28–2.68;P<0.01). The similar combined effect was found in participants with pack-year≥40 and drinking duration≥35 years (OR 1.72; 95% CI 1.26–2.34;P<0.01). Moreover, an interaction was observed between current smoking and moderate drinking in NAFLD.ConclusionsIn elderly Chinese men, cigarette smoking and moderate alcohol consumption exerts an evident joint effect and interaction on the prevalence of NAFLD, although both are significantly and independently associated with NAFLD prevalence. Such findings highlight particular significance of avoidance of cigarette and alcohol on NAFLD prevention.

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Section: Discussionmentioning

confidence: 99%

Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men

Liu¹,

Xu²,

Tang³

et al. 2017

PLoS ONE

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“…First, alcohol use was self-reported, but we have previously validated self-reported alcohol use against HDL-cholesterol and ALDH2 polymorphisms 15 28. Second, this cohort may not be representative of all Chinese.…”

Section: Discussionmentioning

confidence: 99%

“…In the neighbouring city of Hong Kong where the population shares a common ancestry with the participants in GBCS, alcohol use less than or equal to 2 units/day for women and 3 units/day for men, where one unit is 10 g ethanol, has been considered as moderate 14. Therefore, this definition was used in this analysis, and was consistent with other papers using the same sample 15 16. Moderate alcohol users were defined as people using alcohol weekly with average consumption ≤140 g ethanol per week for women and ≤210 g for men.…”

Section: Methodsmentioning

confidence: 97%

Systematic differences among never, occasional and moderate alcohol users in southern China, and its use in alcohol research: a cross-sectional study

Yeung

Jiang

Zhang

et al. 2013

J Epidemiol Community Health

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“…Moreover, it is uncertain whether and to what extent that genetic backgrounds as well as lifestyle factors influence the association between alcohol intake and metabolic outcomes among difference ethical populations. So far, most of studies have been conducted among western populations and only one study investigated the relationship between alcohol intake and fasting glucose in Guangzhou, a southern city of China [6]. Given the substantial variations in lifestyles and disease patterns among peoples living in different geographic locations in China, more studies based on a representative sample of Chinese people are definitely warranted.…”

Section: Introductionmentioning

confidence: 99%

Associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia among middle-aged and elderly Chinese

Liu

Wang

et al. 2010

BMC Public Health

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BackgroundThe U-shaped relationship between alcohol consumption and diabetes mellitus was observed among western populations. However, few studies have systematically evaluated the association in Chinese. We aimed to investigate the associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia (IFG) among middle-aged and elderly Chinese.MethodsWe examined 1,458 men and 1,831 women aged 50 to 70 from Beijing and Shanghai China in a cross-sectional survey. Fasting glucose, adipokines and markers of inflammation were measured. Macronutrients and alcohol consumption were assessed with standardized questionnaires.ResultsCompared with abstainers, alcohol consumption was associated with a decreased risk of having diabetes mellitus in women (OR: 0.41, 95%CI: 0.22-0.78) after controlling for socio-demographic factors, physical activity, smoking, family income, family history of cardiovascular disease or diabetes, macronutrients intake, body mass index, and markers of inflammation and adipokines. In men, both low and high alcohol consumptions were associated with increased risks of having combined diabetes and IFG (ORs 1.36 [95%CI: 1.02-1.82] and 1.50 [95%CI: 1.04-2.15], respectively]. In the multivariable stratified analyses among men, moderate drinkers who had drinking days of ≥ 5 days/week had a deceased likelihood (OR: 0.61, 95%CI: 0.37-0.98) and liquor drinkers had an increased likelihood (OR: 1.47, 95%CI: 1.09-1.98) of having combined diabetes and IFG respectively, compared with the abstainers.ConclusionsAn approximately J-shaped association was observed between alcohol consumption and combined diabetes and IFG among men compared with abstainers in Chinese. Whether moderate alcohol intake could help decrease diabetic risk among Chinese people warrants further investigation.

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Alcohol use and fasting glucose in a developing southern Chinese population: the Guangzhou Biobank Cohort Study

Cited by 19 publications

References 33 publications

Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men

Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men

Systematic differences among never, occasional and moderate alcohol users in southern China, and its use in alcohol research: a cross-sectional study

Associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia among middle-aged and elderly Chinese

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