Alcohol use and clinical manifestations of tuberculosis

Fiske, Christina T.; Hamilton, Carol; Stout, Jason E.

doi:10.1016/j.jinf.2009.02.015

Cited by 36 publications

(49 citation statements)

References 24 publications

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“…In China, ever-smoking TB patients were significantly associated with IVDU (P<0.001) (Leung et al 2003). Furthermore, excess alcohol use has clinical features associated with greater infectiousness of M. tuberculosis (Fiske et al 2008;Lewis and Chamberlain 1963). Consistent with the previous literature, the current study found that alcohol use was significantly associated with ever-smoking TB patients.…”

Section: Discussionsupporting

confidence: 88%

Outcomes of tuberculosis treatment: a retrospective cohort analysis of smoking versus non-smoking patients in Penang, Malaysia

et al. 2010

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Background The association between tobacco smoking and tuberculosis (TB) is increasingly coming to light and the literature is laden with the evidence of this association. However, only a few observational studies specifically investigated the association between smoking and TB treatment outcomes. Aim and methods The present study aims to determine the prevalence of smoking among TB patients in Penang and to compare the treatment outcomes between smoking and non-smoking TB patients. A retrospective estimate of smoking prevalence among patients with TB and a retrospective cohort study comparing smoking and nonsmoking TB patients with regards to treatment outcomes was conducted. The data were extracted from medical records of newly diagnosed TB patients who registered at a chest clinic at a tertiary care hospital in the state of Penang, Malaysia

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Section: Discussionsupporting

confidence: 88%

Outcomes of tuberculosis treatment: a retrospective cohort analysis of smoking versus non-smoking patients in Penang, Malaysia

et al. 2010

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“…Des Bordes [3] also reported a higher prevalence of alcoholism amongst TB-infected patients (49.8%), and other studies have shown that the risk of TB infection increases in persons who consume 40 g of alcohol per day [12]. In addition, a higher prevalence of pulmonary TB and lung cavitations is associated with excess alcohol consumption [13]. In our study, Indians consumed more alcohol than Chinese and Malays, and similar findings were reported by Saroja and Kyaw [14].…”

Section: Discussionmentioning

confidence: 99%

Role of Diabetes in the Prognosis and Therapeutic Outcome of Tuberculosis

Suleiman

Aweis

Mohamed

et al. 2012

International Journal of Endocrinology

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Background. Increased susceptibility of diabetic mellitus (DM) patients to infection, including tuberculosis (TB), is well documented. The prevalence of DM in Malaysia is reaching epidemic proportions. In this study, we sought to assess risk factors for TB and the impact of DM on the outcome of TB treatment. Methods. TB patients, diabetic patients, and diabetic patients with TB were divided into three groups of 200 subjects each. Data were obtained from patients' medical files at the beginning and end of the study period. Prevalence rates of DM and HIV among TB patients were assessed. Prognosis, TB-related complications, anatomical site of infection, and duration of infection and diabetes were also examined. Results. The prevalence rates of HIV and DM amongst TB patients were 7.7 and 30%, respectively. The diabetic TB patient group contained more males (72%) and smokers (45.5%) compared to the nondiabetic group (58.3% and 33.5%, resp.). Approximately 74% of diabetic patients were Mycobacterium sputum positive compared to only 51% of nondiabetic patients. Diabetic patients were also more likely to develop pulmonary TB (87%) compared to nondiabetic TB patients (59%). Diabetic TB patients had a higher mortality rate (7.5%) compared to the TB only and DM only groups (1 and 2%, resp.). The duration of TB symptoms was longer in nondiabetic TB patients compared to diabetic TB patients (4.5 versus 2.6 months, resp.). Diabetes antedated TB by a mean time of 4 years. Conclusions. We found a higher number of sputum-smear-positive cases and pulmonary TB cases as well as a greater number of males and higher mortality rate in diabetic patients compared to nondiabetic patients.

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“…Bacakoglu et al 30 proved that there was no difference in the frequency of cavity occurrence between the diabetics and individuals without diabetes. In their study, Kiyan et al 25 reached results that showed no significant difference in the frequency of cavity occurrence between the immunocompromised individuals (who are not HIV positive) and immunocompetent individuals, whereas Fiske et al 29 proved that there was a higher frequency of cavity occurrence among the alcoholics. Perez-Guzman et al 26 , Jabbar et al 28 and Singla et al 27 published results showing that the majority of diabetics had radiological changes in lower lobes.…”

Section: Discussionmentioning

confidence: 96%

“…Singla et al 27 also proved that diabetics require longer time for the conversion of sputum cultures to M. tuberculo-sis. In a study conducted in North Carolina, Fiske et al 29 proved that there was a higher frequency of patients with positive sputum smear among the individuals who used alcohol excessively.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis in the immunocompromised patients

Vukosav

Tot-Veres²

2019

VOJNOSANIT PREGL

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Background/Aim. During the last few decades, immunocompromising diseases led to an increase in the number of tuberculosis cases. The aim of this study was to examine the influence of immunocompromising diseases on the course of tuberculosis. Methods. The research included two groups, each consisting of 40 subjects with tuberculosis, who were treated at the Institute for Pulmonary Diseases of Vojvodina during 2010 and 2011. The first group had no immunocompromising diseases (the kontrol group), whereas the second group contained patients with accompanying immunocompromising diseases. The data from the patients' medical history, from the Center for Microbiology and from the Radiology Center were used. The two groups were compared according to the following characteristics: age, sex, bacteriological status, radiological presence of the disease, presence of adverse effects of drugs, presence of resistance to drugs, duration of the therapy regimen and the duration of hospitalization. Results. The group of immunocompromised patients was older in average than the control group and included a higher percentage of males. The immunocompromised group had statistically important longer average time required for the sputum smear conversion (p = 0.000) and for the conversion of sputum cultures to M. tuberculosis (p = 0.010), more frequent presence of cavity (p = 0.030), longer average therapy regimen duration (p = 0.000) and higher average number of hospital days (p = 0.000) compared to the control group. The most frequent localization of changes in the immunocompromised patients was in all lobes of both lungs (32.5%) whereas the changes in the control group were mostly localized in the upper lung lobes (62.5%). There was no statistically important difference in the finding of sputum smear positive acidfast bacilli on direct micoscropy, the presence of adverse effects of drugs and M. tuberculosis resistance to drugs between the two groups of patients. Conclusion. The immunocompromising diseases change the course of tuberculosis, primarily by affecting bacteriological status, radiological presentation, the length of therapy regimen and the duration of hospitalization. ApstraktUvod/Cilj. Imunokompromitujuće bolesti su tokom poslednjih decenija dovele do porasta broja obolelih od tuberkuloze. Cilj rada je bio da se ispita uticaj imunokompromitujućih bolesti na tok tuberkuloze. Metode. Ispitivanjem su obuhvaćene dve grupe od po 40 bolesnika obolelih od tuberkuloze koji su lečeni u Institutu za plućne bolesti Vojvodine tokom 2010. i 2011. godine. Prva grupa nije imala imunokompromitujuće bolesti (kontrolna grupa), dok su u drugoj grupi bili bolesnici sa pridruženim imunokompromitujućim bolestima. Korišćeni su podaci iz istorija bolesti, podaci Centra za mikrobiologiju i Centra za radiologiju. Dve grupe su poređene prema sledećim karakteristikama: starost, pol, bakteriološki status, radiološki nalaz, prisustvo neželjenih efekata lekova, prisustvo rezistencije M. tuberculosis na lekove, trajanje terapijskog režima i dužina hospitaliz...

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Alcohol use and clinical manifestations of tuberculosis

Cited by 36 publications

References 24 publications

Outcomes of tuberculosis treatment: a retrospective cohort analysis of smoking versus non-smoking patients in Penang, Malaysia

Outcomes of tuberculosis treatment: a retrospective cohort analysis of smoking versus non-smoking patients in Penang, Malaysia

Role of Diabetes in the Prognosis and Therapeutic Outcome of Tuberculosis

Pulmonary tuberculosis in the immunocompromised patients

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