Alcohol, sludge, and hypoxic areas of nervous system, liver and heart

Moskow, Herbert; Pennington, Raymond C.; Knisely, Melvin H.

doi:10.1016/0026-2862(68)90016-2

Cited by 30 publications

(6 citation statements)

References 27 publications

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“…Brain damage related to the excessive use of alcohol (even though in the past) appears to clear more rapidly and completely than that related to arteriosclerosis alone. Such a good response is similar to that in patients with diabetes, and probably for the same reason, i.e., alcohol, like diabetes, can cause blood sludging (13), a condition that can be reversed by an ticoagulant therapy.…”

Section: Casesupporting

confidence: 88%

Presenile Dementia: Further Experience with an Anticoagulant‐Psychotherapy Regimen*

Walsh

Walsh²

1974

J American Geriatrics Society

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The principles of an anticoagulant-psychotherapy regimen for presenile dementia are discussed. Short histories are given of 10 patients (including one with Huntington's chorea as well as dementia) who responded well to this treatment. It is important to keep the blood prothrombin time at 2.0-2.5 times the control time. The earlier treatment is started, the better the result. Even in cases in which there is n o significant improvement, the prevention of further deterioration is of great value. If properly controlled, this regimen is relatively safe and can maintain or improve the quality of life for dementia patients. When brain deterioration is observed in patients past the age of 70, it is usually accepted as an unfortunate manifestation associated with the aging process. However, when observed in patients of the 40-60 age group, it is one of the most puzzling problems in medicine. Traditionally, age 6 5 is arbitrarily chosen as the dividing line for nomenclature: after that age the brain deterioration is called senile dementia; before that age it is called presenile dementia. It is our hypothesis that they both represent variations of cerebrovascular insufficiency, regardless of age. This paper concerns our recent experience with a therapeutic regimen developed during the past eleven years. Ten patients have responded favorably to this treatment in such a way as to refute the general belief that presenile dementia is an irreversible disorder with a steady downhill course.Nineteen years of general practice have afforded the writer ample opportunity for ob-

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Section: Casesupporting

confidence: 88%

Presenile Dementia: Further Experience with an Anticoagulant‐Psychotherapy Regimen*

Walsh

Walsh²

1974

J American Geriatrics Society

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“…The possibility has not been ruled out that ethanol's actions are, in part at least, associated with a reduction of microcirculation (MOSKOW et al, 1968;KNISELY et al, 1969;PENNINGTON and KNISELY, 1973). Data exist to support a direct relationship; there have been no confirming studies of which this writer is aware.…”

Section: Alterations In Microcirculationmentioning

confidence: 64%

The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

Smith¹

1977

Drug Addiction I

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“…Therapy is based upon two physiologic principles: (a) alcohol causes blood sludging which produces ischemia of the brain and neurone damage (2); and (b) anticoagulant drugs can relieve or prevent blood sludging (3) and thus the improved blood flow may revive many viable but nonfunctioning brain cells. As viable brain cells resume function and become re‐integrated regarding behavior patterns, maximal clinical improvement may be enhanced by suitable milieu and psychotherapy together with family therapy, to assist in the resocialization process.…”

Section: Results Of Dicumarol Therapy In 15 Patients With Organic Bramentioning

confidence: 99%

Alcoholic Brain Damage: Anticoagulant Therapy

Walsh¹,

Lukás²

1974

J American Geriatrics Society

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Alcohol, sludge, and hypoxic areas of nervous system, liver and heart

Cited by 30 publications

References 27 publications

Presenile Dementia: Further Experience with an Anticoagulant‐Psychotherapy Regimen*

Presenile Dementia: Further Experience with an Anticoagulant‐Psychotherapy Regimen*

The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

Alcoholic Brain Damage: Anticoagulant Therapy

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