Alcohol-Related Elevation of Liver Transaminase Is Associated With Gut Microbiota in Male

Jiao, Mengfan; Su, Yan; Shi, Qingmiao; Liu, Ying; Li, Yaoguang; Lv, Jun; Ding, Shuzhe; Li, Ang

doi:10.3389/fmed.2022.823898

Cited by 10 publications

(8 citation statements)

References 44 publications

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“…Alcoholic liver damage is usually identified by elevated liver transaminase. A recent study investigating the role of the gut microbiome in individual susceptibility to alcoholic liver injury showed that R. gnavus exhibited the strongest positive association with alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and contributed to liver inflammation (Jiao et al 2022 ).…”

Section: Association Between R Gnavus and Diseasesmentioning

confidence: 99%

Ruminococcus gnavus: friend or foe for human health

Crost

Coletto

Bell

et al. 2023

FEMS Microbiology Reviews

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Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extra-intestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterisation of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonisation of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific.

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Section: Association Between R Gnavus and Diseasesmentioning

confidence: 99%

Ruminococcus gnavus: friend or foe for human health

Crost

Coletto

Bell

et al. 2023

FEMS Microbiology Reviews

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“…Third, despite widespread adjustment in our study, unmeasured confounders such as alcohol consumption may explain part of this association. Alcohol consumption is a great risk factor for liver damage and it's estimated that about 35% of alcohol drinkers developed early liver disease; the issue that might affected by the individual gut microbiome 56,57 . According to the systematic review and meta‐analysis study, 58 one out of eight general population of Iran reported consumption of alcohol despite its legal prohibition.…”

Section: Discussionmentioning

confidence: 99%

“…Alcohol consumption is a great risk factor for liver damage and it's estimated that about 35% of alcohol drinkers developed early liver disease; the issue that might affected by the individual gut microbiome. 56 , 57 According to the systematic review and meta‐analysis study, 58 one out of eight general population of Iran reported consumption of alcohol despite its legal prohibition. Therefore further study is required to evaluate alcohol‐related harms for liver disease in Iran.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and metabolic determinants of abnormal alanine aminotransferase: A cross‐sectional study of Iranian adults, 2018–2022

Asgari

Molavizadeh

Tohidi

et al. 2023

Clinical Laboratory Analysis

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BackgroundAlanine aminotransferase (ALT) is an enzyme whose activity became the principal biomarker for liver disease. In the current study, we aimed to determine the prevalence of abnormal ALT, as a surrogate of nonalcoholic fatty liver disease (NAFLD) and its associated determinants using different criteria among Tehranian subjects between 2018 and 2022.MethodsThis is a cross‐sectional study on 5676 Tehranian individuals aged 20–70 years. The weighted prevalence of abnormal ALT was calculated using both the National Health and Nutrition Examination Survey in the United States (US‐NHANCE; ALT ≥30 U/L for females and ≥40 U/L for males) and the American College of Gastroenterology (ACG) guideline (ALT >25 U/L for females, and >33 U/L for males) thresholds. Moreover, uni/multivariable logistic regression analysis was performed to find the determinants of abnormal ALT.ResultsThe weighted prevalence of abnormal ALT was 12.8% (7.6% females and 18% males) and 22.5% (17.7% females and 27.3% males) based on US‐NHANCE and ACG criteria, respectively. Our results showed every decade increase in age decreased the risk of abnormal ALT by 32%. We also found that generally male gender, being overweight/obese, central adiposity, TG ≥6.9 mmol/L, non‐HDL‐C ≥3.37 mmol/L, lipid‐lowering medications, pre‐diabetes/T2DM were associated with abnormal ALT using different cutoff points. Moreover, among men resting tachycardia (≥90 beats per min), hypertension, and females past‐smoker were also found as other determinants of abnormal ALT.ConclusionHigh prevalence of abnormal ALT among non‐elderly Iranian adults, especially among men, necessitates immediate multifaceted strategies by policymakers to prevent potential complications caused by NAFLD.

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“…Overgrowth of endogenous or exogenous Escherichia leads to altered gut microbiota and disrupts gut immune homeostasis, leading to gut inflammation, depression, and cognitive impairment by inducing IL-1β and corticosterone production ( 28 , 46 ). Jiao et al reported that the abundance of Faecalibacterium was significantly reduced in the drinking case group and its protective effect on inflammatory liver injury ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

Gong

et al. 2022

Front. Psychiatry

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IntroductionAlcohol use disorder (AUD) has evolved into a severe social and medical issue. However, the exact environmental factors triggering AUD pathophysiology remain unknown. A growing body of research has shown that environmental elements can affect the brain via the microbiota-gut-brain axis.MethodsWe employed 16S rRNA gene sequencing technology to investigate the composition and diversity of intestinal microbiota in 32 AUD males and 35 healthy controls (HCs), as well as its relationship on cognitive function.ResultsOur findings showed that the alpha diversity indices in AUDs were much lower than HCs. The abundances of Faecalibacterium, Gemmiger, Lachnospiracea_incertae_sedis, Megamonas, and Escherichia were significantly different between AUD and HC groups and could be used as a basis for judging whether excessive drinking. The abundances of Faecalibacterium, Gemmiger, Escherichia, and Fusobacterium can be used to judge the cognitive function of the population.ConclusionThese data suggested that the gut dysbiosis in AUD patients, and some specific microbiota were considered to be related to alcohol intake and cognitive function. This study provides important information for further study of the pathogenesis of AUD from the perspective of intestinal microbiota.

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Alcohol-Related Elevation of Liver Transaminase Is Associated With Gut Microbiota in Male

Cited by 10 publications

References 44 publications

Ruminococcus gnavus: friend or foe for human health

Ruminococcus gnavus: friend or foe for human health

Prevalence and metabolic determinants of abnormal alanine aminotransferase: A cross‐sectional study of Iranian adults, 2018–2022

The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

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