Alcohol-Related Dementia: A Systemic Review of Epidemiological Studies

Cheng, Chih‐Tao; Huang, Chieh-Liang; Tsai, Chia Jui; Chou, Po-Han; Lin, Chih-Chien; Chang, Chin‐Kuo

doi:10.1016/j.psym.2017.02.012

Cited by 52 publications

(34 citation statements)

References 18 publications

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“…The current inability to separate the consequences of thiamine deficiency (TD) from those of ethanol neurotoxicity (EN) is not due to some insurmountable obstacle. Nonetheless, it has led to hybrid diagnoses and umbrella terms like “alcohol-related dementia” 36 – 38 or “alcohol-related brain injury.” 39 These current “alcohol-related” concepts and diagnoses hamper the clinical diagnosis of KS and complicate its scientific study. We would like to argue that there are no valid reasons why a reliable definition and reliable diagnostic criteria for KS would be harder to devise than definitions or criteria for, say, Alzheimer’s disease (AD).…”

Section: Definition Diagnosis and Epidemiologymentioning

confidence: 99%

Korsakoff’s syndrome: a critical review

Arts

Walvoort

Kessels

2017

NDT

215

174

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In this review, we present a survey on Korsakoff’s syndrome (KS), a residual syndrome in patients who suffered from a Wernicke encephalopathy (WE) that is predominantly characterized by global amnesia, and in more severe cases also by cognitive and behavioral dysfunction. We describe the history of KS and its definition, its epidemiology, and the lack of consensus criteria for its diagnosis. The cognitive and behavioral symptoms of KS, which include anterograde and retrograde amnesia, executive dysfunction, confabulation, apathy, as well as affective and social-cognitive impairments, are discussed. Moreover, recent insights into the underlying neurocognitive mechanisms of these symptoms are presented. In addition, the evidence so far on the etiology of KS is examined, highlighting the role of thiamine and alcohol and discussing the continuity hypothesis. Furthermore, the neuropathology of KS is reviewed, focusing on abnormalities in the diencephalon, including the mammillary bodies and thalamic nuclei. Pharmacological treatment options and nonpharmacological interventions, such as those based on cognitive rehabilitation, are discussed. Our review shows that thiamine deficiency (TD) is a crucial factor in the etiology of KS. Although alcohol abuse is by far the most important context in which TD occurs, there is no convincing evidence for an essential contribution of ethanol neurotoxicity (EN) to the development of WE or to the progression of WE to KS. Future research on the postmortem histopathological analysis of brain tissues of KS patients is crucial for the advancement of our knowledge of KS, especially for associating its symptoms with lesions in various thalamic nuclei. A necessary requirement for the advancement of studies on KS is the broad acceptance of a comprehensive definition and definite diagnostic criteria. Therefore, in this review, we propose such a definition of KS and draft outlines for prospective diagnostic criteria.

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Section: Definition Diagnosis and Epidemiologymentioning

confidence: 99%

Korsakoff’s syndrome: a critical review

Arts

Walvoort

Kessels

2017

NDT

215

174

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“…Previous studies found inconsistent results on the relation between alcohol consumption and cognitive performance. The majority of studies indicate that long-term heavy drinking has strong negative associations with diseases of the brain such as dementia [35]. Many short-term studies indicate cognitive impairment in heavy binge drinkers as compared to nondrinking controls [8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Alcohol Consumption, Drinking Patterns, and Cognitive Performance in Young Adults: A Cross-Sectional and Longitudinal Analysis

Hendriks¹,

Rest

Snippe

et al. 2020

Nutrients

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Long-term alcohol abuse is associated with poorer cognitive performance. However, the associations between light and moderate drinking and cognitive performance are less clear. We assessed this association via cross-sectional and longitudinal analyses in a sample of 702 Dutch students. At baseline, alcohol consumption was assessed using questionnaires and ecological momentary assessment (EMA) across four weeks (‘Wave 1’). Subsequently, cognitive performance, including memory, planning, and reasoning, was assessed at home using six standard cognition tests presented through an online platform. A year later, 436 students completed the four weeks of EMA and online cognitive testing (‘Wave 2’). In both waves, there was no association between alcohol consumption and cognitive performance. Further, alcohol consumption during Wave 1 was not related to cognitive performance at Wave 2. In addition, EMA-data-based drinking patterns, which varied widely between persons but were relatively consistent over time within persons, were also not associated with cognitive performance. Post-hoc analyses of cognitive performance revealed higher within-person variance scores (from Wave 1 to Wave 2) than between-person variance scores (both Wave 1 and Wave 2). In conclusion, no association was observed between alcohol consumption and cognitive performance in a large Dutch student sample. However, the online cognitive tests performed at home may not have been sensitive enough to pick up differences in cognitive performance associated with alcohol consumption.

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“… Systematic review Billioti de Gage et al, 2015 Moderate alcohol consumption + High proportion of alcohol-related dementia in early-onset dementia. Systematic review Cheng et al, 2017 + Middle-aged adults with a history of alcohol use disorders have increased odds of developing severe memory impairment later in life. Prospective cohort study (19 years, 6500 participants) Kuźma et al, 2014 + Alcohol use disorders were a major risk factor for onset of all types of dementia, and especially early-onset dementia.…”

Section: Table A1mentioning

confidence: 99%

Making DEEP Sense of Lifestyle Risk and Resilience

Kempermann

2019

Front. Aging Neurosci.

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To effectively promote life-long health and resilience against – for example – neurodegenerative diseases, evidence-based recommendations must acknowledge the complex multidimensionality not only of the diseases but also of personal lifestyle. In a straightforward descriptive and heuristic framework, more than 50 potential lifestyle factors cluster around diet (D), education (E), exercise (E), and purpose (P), unveiling their many relationships across domains and scales. The resulting systematics and its visualization might be a small but helpful step toward the development of more comprehensive, interdisciplinary models of lifestyle-dependent risk and resilience and a means to explain the opportunities and limitations of preventive measures to the public and other stakeholders. Most importantly, this perspective onto the subject implies that not all lifestyle factors are created equal but that there is a hierarchy of values and needs that influences the success of lifestyle-based interventions.

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Alcohol-Related Dementia: A Systemic Review of Epidemiological Studies

Cited by 52 publications

References 18 publications

Korsakoff’s syndrome: a critical review

Korsakoff’s syndrome: a critical review

Alcohol Consumption, Drinking Patterns, and Cognitive Performance in Young Adults: A Cross-Sectional and Longitudinal Analysis

Making DEEP Sense of Lifestyle Risk and Resilience

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Alcohol-Related Dementia: A Systemic Review of Epidemiological Studies

Cited by 52 publications

References 18 publications

Korsakoff&rsquo;s syndrome: a critical review

Korsakoff&rsquo;s syndrome: a critical review

Alcohol Consumption, Drinking Patterns, and Cognitive Performance in Young Adults: A Cross-Sectional and Longitudinal Analysis

Making DEEP Sense of Lifestyle Risk and Resilience

Contact Info

Product

Resources

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Korsakoff’s syndrome: a critical review

Korsakoff’s syndrome: a critical review