Alcohol promotes waste clearance in the CNS via brain vascular reactivity

Cheng, Yiming; Liu, Xinglei; Ma, Xiaotang; García, Ricardo Juan Bosch; Belfield, Kevin D.; Haorah, James

doi:10.1016/j.freeradbiomed.2019.07.029

Cited by 20 publications

(12 citation statements)

References 50 publications

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“…The effect of alcohol on cerebral SMCs is debatable. A recent study reported that low-dose alcohol increases the activity of eNOS and generation of NO in rat brain ECs and promotes the EC-SMCs interaction, thus inducing brain arterial vessel dilation (44), whereas previous studies suggested that, even in physiological concentrations, alcohol elicits lipid peroxidation and apoptosis in primary canine cerebral artery SMCs, which contributes to brain-vascular damage and stroke (7,133,272). Nevertheless, the detrimental effect of excessive alcohol drinking on cerebral arteries has reached a consensus, as it induces contraction in both isolated rings and primary SMCs of the cerebral artery in both canine and rodent models, which can be mediated through MAPK activation, protein kinase C, and PI3K activation (29,(262)(263)(264).…”

Section: Other Factors Associated With Vascular Diseasementioning

confidence: 99%

Metabolism of vascular smooth muscle cells in vascular diseases

Shi

Yang

Cheng

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

196

120

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Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer of arteries and are essential for arterial physiology and pathology. It is becoming increasingly clear that VSMCs can alter their metabolism to fulfill the bio-energetic and biosynthetic requirements. During vascular injury, VSMCs switch from a quiescent "contractile" phenotype to a highly migratory and proliferative "synthetic" phenotype. Recent studies find that the phenotype switching of VSMCs is driven by a metabolic switch. Metabolic pathways, including aerobic glycolysis, fatty acid oxidation, and amino acid metabolism, have distinct, indispensable roles in normal and dysfunctional vasculature. VSMCs metabolism is also related to the metabolism of endothelial cells. In the present review, we present a brief overview of VSMCs metabolism, and how it regulates the progression of several vascular diseases, including atherosclerosis, systemic hypertension, diabetes, pulmonary hypertension, vascular calcification, and aneurysms, and the effect of the risk factors for vascular disease (aging, cigarette smoking and excessive alcohol drinking) on VSMCs metabolism, to clarify the role of VSMCs metabolism in the key pathological process.

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Section: Other Factors Associated With Vascular Diseasementioning

confidence: 99%

Metabolism of vascular smooth muscle cells in vascular diseases

Shi

Yang

Cheng

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

196

120

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“…This study suggested a new avenue for treating AD by targeting beta-amyloid in the ISS. Another study suggested that alcohol intake at low-dose levels promotes the clearance of metabolic waste products, including neurodegenerative diseaserelated proteins through the ISS [120].…”

Section: Status Of Iss In Neurological Disordersmentioning

confidence: 99%

The Interstitial System of the Brain in Health and Disease

Shetty

Zanirati

2020

Aging and disease

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The brain interstitial fluid (ISF) and the cerebrospinal fluid (CSF) cushion and support the brain cells. The ISF occupies the brain interstitial system (ISS), whereas the CSF fills the brain ventricles and the subarachnoid space. The brain ISS is an asymmetrical, tortuous, and exceptionally confined space between neural cells and the brain microvasculature. Recently, with a newly developed in vivo measuring technique, a series of discoveries have been made in the brain ISS and the drainage of ISF. The goal of this review is to confer recent advances in our understanding of the brain ISS, including its structure, function, and the various processes mediating or disrupting ISF drainage in physiological and pathological conditions. The brain ISF in the deep brain regions has recently been demonstrated to drain in a compartmentalized ISS instead of a highly connected system, together with the drainage of ISF into the cerebrospinal fluid (CSF) at the surface of the cerebral cortex and the transportation from CSF into cervical lymph nodes. Besides, accumulation of tau in the brain ISS in conditions such as Alzheimer's disease and its link to the sleep-wake cycle and sleep deprivation, clearance of ISF in a deep sleep via increased CSF flow, novel approaches to remove beta-amyloid from the brain ISS, and obstruction to the ISF drainage in neurological conditions are deliberated. Moreover, the role of ISS in the passage of extracellular vesicles (EVs) released from neural cells and the rapid targeting of therapeutic EVs into neural cells in the entire brain following an intranasal administration, and the promise and limitations of ISS based drug delivery approaches are discussed Key words: beta-amyloid, cerebrospinal fluid, extracellular matrix, extracellular vesicles, glymphatic system, interstitial fluid, phosphorylated tau contiguous glia, or the adjoining neurons and glia is also known as the extracellular space (ECS) [1-3].

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“…Some animal model studies found negative association between alcohol and cognition mediated by reductions in cell density in the cerebral cortex [ 102 ] and alterations of cholinergic interneurons in the Nucleus Accumbens [ 103 ]. Other animal model studies suggested positive association between alcohol and cognition thought to be mediated by enhancement of brain metabolite clearance [ 104 ] and activation of the vagus nerve [ 105 ], antioxidant system [ 106 , 107 , 108 , 109 ], and other biological processes [ 110 , 111 , 112 ]. However, none of these findings have thus far been confirmed to be causally important.…”

Section: Discussionmentioning

confidence: 99%

Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder

et al. 2021

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The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.

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Alcohol promotes waste clearance in the CNS via brain vascular reactivity

Cited by 20 publications

References 50 publications

Metabolism of vascular smooth muscle cells in vascular diseases

Metabolism of vascular smooth muscle cells in vascular diseases

The Interstitial System of the Brain in Health and Disease

Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder

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