“…The increased risk of HIV infection may be attributable to the social consequences of substance use, which facilitates unprotected sex. The physiological effects of substance use on decision-making (Dingle & Oei, 1997; Simons, Maisto, & Wray, 2010; Steele & Josephs, 1990), the altered expectations of condom use when using substances (Gálvez-Buccollini et al, 2008; Maisto, Carey, Carey, & Gordon, 2002), and certain personality types being more likely to engage in all forms of risky behaviours (Cooper, Wood, Orcutt, & Albino, 2003; Hagger-Johnson, Bewick, Conner, O’Connor, & Shickle, 2011; Newcomb, Clerkin, & Mustanski, 2011), may increase the likelihood of risky sex and therefore HIV infection. Substance use is also likely to be on the causal pathway between orphanhood and increased risk of HIV acquisition as the significant association of orphanhood with higher numbers of partners disappeared after adjusting for substance use, implying that substance use may be a mediating factor for orphans.…”