Alcohol metabolism are improved by yeast extract mixtures than Hovenia Dulcis mixtures in healthy men: a double‐blind, randomized crossover, placebo‐controlled trial (LB441)

Abstract

Alcohol hangover is an unpleasant aftermath of heavy alcohol drinking. Hangover onset starts after the oral administration of alcohol since ethanol, a key component of the alcoholic drinks, metabolized to acetaldehyde. In this study, we investigated whether the supplement formula might improve the alcohol metabolism in healthy adult men. In a double‐blinded, randomized, crossover study, subjects were received yeast extract mixtures (YEM, n=21), Hovenia Dulcis mixtures (HDM, n=21), placebo (PLC, n=21), and control (CON, n=21) in separate 4 week supplementation periods at a single oral dose followed by one week washout periods. At each visit (0, 1, 2, 3, 4 weeks), the subjects drank 450 mL 23 % alcohol simultaneously with mixtures and blood was drawn periodically (0, 0.25, 0.5, 1, 2, 4, 6, 15 hr). Fifteen subjects completed the protocol and included in the analysis. The plasma ethanol concentrations were tended to lower in the YEM (10 %) and the HDM (5 %) groups. The area under the curves (AUCs) and Cmax for plasma ethanol were significantly decreased only in the YEM group, when compared with the CON group. The AUCs and Cmax for plasma acetaldehyde concentration were significantly decreased in the YEM (45 % and 54 %) and the HDM (35 % and 53 %) groups respectively, when compared with PLC (P<0.01). These findings demonstrated that alcohol metabolism and hangover syndromes might improve by YEM than HDM.