Alcohol, Liver, Systemic Inflammation and Skin: A Focus on Patients with Psoriasis

Farkas, Árpád; Kemény, Lajos

doi:10.1159/000348865

Cited by 36 publications

(43 citation statements)

References 132 publications

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“…In addition, alcohol contributes to an increased incidence of anxiety and depression, and a greater intake of saturated fats. It is also associated with a poorer response to treatment [81,88].…”

Section: Dieta W łUszczycymentioning

confidence: 99%

“…Wykazano dodatnią korelację spożycia alkoholu z nasileniem łuszczycy. Alkohol powoduje rozszerzenie naczyń, ułatwiając migrację komórek zapalnych, zwiększa stężenie kwasu arachidonowego, nasila stres oksydacyjny, wpływa na częstsze wystę-powanie lęku i depresji, sprzyja większemu spożyciu tłuszczów nasyconych, zmniejsza odpowiedź na leczenie [81,88].…”

Section: Dieta W łUszczycyunclassified

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The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.streszczenie Łuszczyca, która występuje u 2-4% populacji na świecie, jest przewlekłą i nawrotową chorobą zapalną skóry. Na jej wieloczynnikową etiopatogenezę składają się m.in. nieprawidłowa proliferacja naskórka, zaburzenia immunologiczne, czynniki genetyczne, psychosomatyczne, środowiskowe i hormonalne. Łuszczyca jest również uznawana za schorzenie ogólnoustrojowe, związane z chorobami układu sercowo--naczyniowego, miażdżycą, cukrzycą, otyłością i zespołem metabolicznym. Lipidy pełnią wiele biologicznych funkcji, biorą udział nie tylko w magazynowaniu i wydatkowaniu energii, tworzeniu błon komórko-wych, lecz także w zapalnych i metabolicznych szlakach sygnałowych. Zaburzenia ich homeostazy powodują rozwój schorzeń immunometabolicznych, w tym łuszczycy. W niniejszej pracy przedstawiono na podstawie dostępnego piśmiennictwa wybrane aspekty molekularne i kliniczne wielokierunkowego wpływu lipidów na łuszczycę.

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Section: Dieta W łUszczycymentioning

confidence: 99%

Section: Dieta W łUszczycyunclassified

The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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“…Chronicity, the recurring course of psoriasis, the absence of a cure and several side effects of available treatment modalities result in a major reduction in the quality of life and the physical and psychological functioning of psoriatic patients [2,3,4,5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment

Archid¹,

Duerr²,

Patzelt

et al. 2016

Skin Pharmacol Physiol

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Alterations of the skin microvasculature are known to play an important role in the development and maintenance of psoriatic skin lesions. In this study, we investigated lesional skin in 11 psoriatic patients during a modified Goeckerman treatment using reflectance confocal microscopy (RCM) to study the relationship between clinical clearance and histological normalization of psoriatic skin and the significance of histological abnormalities on the course of disease. The treatment regimen resulted in a significant reduction of the Psoriasis Area and Severity Index (PASI) as well as capillary and papillary diameters (p < 0.0001). The capillary and papillary diameters were still enlarged when compared to those in normal skin (p < 0.001). Capillary and papillary diameters correlated with each other prior to and after treatment (correlation coefficient = 0.63 and 0.64, p = 0.01 and 0.002, respectively) but not with the PASI. Capillary and papillary diameters after treatment and percentage reduction of the PASI during treatment seemed to be better predictors for the clinical course of relapse than the PASI after treatment. These findings make the subclinical changes of psoriatic skin vessels and dermal papillae a legitimate target for treatment. Further investigations of a large group of patients are needed to evaluate the potential of RCM findings as successor of the PASI in the monitoring of psoriasis.

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“…Others are focusing on the role of microRNAs in the gastrointestinal tract, and how the microbiome may be a possible source of alcohol-mediated infection/sepsis (Morris, Li, Earley, & Choudhry, 2015;Mutlu et al, 2012). Finally, groups are starting to understand the underlying mechanisms of alcohol in other pathologies including psoriasis and cancer (Farkas & Kemeny, 2013;Poschl & Seitz, 2004).…”

Section: Introductionmentioning

confidence: 99%