Alcohol intake, reproductive hormones, and menstrual cycle function: a prospective cohort study

Schliep, Karen C.; Zarek, Shvetha M.; Wactawski‐Wende, Jean; Trevisan, Maurizio; Sjaarda, Lindsey A.; Perkins, Neil J.

doi:10.3945/ajcn.114.102160

Cited by 31 publications

(19 citation statements)

References 54 publications

(91 reference statements)

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“…Alcohol use can have harmful effects on reproductive functions and is associated with significant sex hormone changes in women (Schliep et al, 2015). The association between ADH1B rs1229984 and age of onset of menopause is in agreement with these previous findings: women with a protective allele for drinking behaviors undergo menopause (a physiological process strictly regulated by sex hormones) later than those without the allele.…”

Section: Discussionsupporting

confidence: 90%

Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women

Polimanti

Kranzler

2016

Neuropsychopharmacol

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To identify novel traits associated with alleles known to predispose to alcohol and nicotine use, we conducted a phenome-wide association study (PheWAS) in a large multi-population cohort. We investigated 7688 African-Americans, 1133 Asian-Americans, 14 081 EuropeanAmericans, and 3492 Hispanic-Americans from the Women's Health Initiative, analyzing alleles at the CHRNA3-CHRNA5 locus, ADH1B, and ALDH2 with respect to phenotypic traits related to anthropometric characteristics, dietary habits, social status, psychological traits, reproductive history, health conditions, and nicotine/alcohol use. In ADH1B trans-population meta-analysis and population-specific analysis, we replicated prior associations with drinking behaviors and identified multiple novel phenome-wide significant and suggestive findings related to psychological traits, socioeconomic status, vascular/metabolic conditions, and reproductive health. We then applied Bayesian network learning algorithms to provide insight into the causative relationships of the novel ADH1B associations: ADH1B appears to affect phenotypic traits via both alcohol-mediated and alcohol-independent effects. In an independent sample of 2379 subjects, we also replicated the novel ADH1B associations related to socioeconomic status (household gross income and highest grade finished in school). For CHRNA3-CHRNA5 risk alleles, we replicated association with smoking behaviors, lung cancer, and asthma. There were also novel suggestive CHRNA3-CHRNA5 findings with respect to high-cholesterol-medication use and distrustful attitude. In conclusion, the genetics of alcohol and tobacco use potentially has broader implications on physical and mental health than is currently recognized. In particular, ADH1B may be a gene relevant for the human phenome via both alcohol metabolism-related mechanisms and other alcohol metabolismindependent mechanisms.

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Section: Discussionsupporting

confidence: 90%

Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women

Polimanti

Kranzler

2016

Neuropsychopharmacol

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“…In epidemiological studies, adjusting for differences is crucial to the robustness of results, to avoid exaggeration or underestimation of risk estimates [16]. In the present meta-analysis, most study designs did not adequately control for important confounders, such as alcohol drinking [42], obesity [43] and education [4], although no statistically significant differences were observed in the subgroup analyses. Only one study considered the factor of family history of non-Hodgkin's lymphoma.…”

Section: Discussionmentioning

confidence: 69%

Number of parity and the risk of non-Hodgkin lymphomas: a dose–response meta-analysis of observational studies

et al. 2016

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“…While it is known that repeated chronic use of alcohol and high blood alcohol levels cause damage to a variety of body systems and lead to mortality, these risks are heightened for women (Zheng et al, 2015). Even after only one drinking occasion, the harmful impact of alcohol in female participants can be observed by assessing the status of reproductive hormones (Schliep et al, 2015). Despite such findings, young women now engage in binge drinking at high rates that are similar to young men.…”

Section: Discussionmentioning

confidence: 99%

Effects of artificial sweeteners on breath alcohol concentrations in male and female social drinkers

Stamates

Maloney

Marczinski

2015

Drug and Alcohol Dependence

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Background Alcohol is often mixed with various nonalcoholic beverages. While consumption of food with alcohol will decrease peak breath alcohol concentrations (BrAC), recent evidence has suggested that mixing alcohol with diet beverages can result in higher BrAC when compared with mixing the same amount of alcohol with sweetened beverages. The purpose of this study was to examine this phenomenon using two different moderate alcohol doses. Methods Twenty participants (10 males) attended five sessions where they received 1 of 5 doses (0.91 ml/kg vodka + 3.64 ml/kg of diet soda, 0.91 ml/kg vodka + 3.64 of regular soda, 1.82 ml/kg vodka + 7.28 ml/kg diet soda, 1.82 ml/kg vodka + 7.28 ml/kg regular soda, and a placebo beverage). BrAC was recorded repeatedly up to 180 minutes after dose administration. Results Participants had significantly higher BrAC when the mixer was diet as compared to regular for both alcohol dose conditions. No gender differences were observed. Conclusions Mixing alcohol with diet beverages can result in higher BrAC when compared to the same amount of alcohol administered with a similar sweetened beverage. Individuals who consume diet mixers with alcohol may reduce caloric intake but increase the harms associated with higher BrACs.

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Alcohol intake, reproductive hormones, and menstrual cycle function: a prospective cohort study

Cited by 31 publications

References 54 publications

Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women

Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women

Number of parity and the risk of non-Hodgkin lymphomas: a dose–response meta-analysis of observational studies

Effects of artificial sweeteners on breath alcohol concentrations in male and female social drinkers

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