Alcohol intake and cardiovascular risk factor profile in men participating in the WOBASZ study

Waśkiewicz, Anna; Sygnowska, Elżbieta

doi:10.5603/kp.2013.0063

Cited by 30 publications

(40 citation statements)

References 28 publications

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“…With women in a rural African setting making up the majority of our study population, it is plausible that users of alcohol would be mostly low-to-moderate drinkers. Alcohol consumption should however be discouraged because its deleterious effects on ART adherence and HIV progression [33] and on other cardiac-metabolic disorders [34] do outweigh this supposedly positive effect on lipid parameters. Incidentally, patients with existing metabolic disorders (all of whom were sufferers of type 2 diabetes mellitus) have been shown to have very high odds of dyslipidaemia (LDL-c) in this study.…”

Section: Discussionmentioning

confidence: 99%

The lipid profile of HIV-infected patients receiving antiretroviral therapy in a rural Cameroonian population

Bekolo¹,

Nguena²,

Ewane

et al. 2014

BMC Public Health

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BackgroundLong term use of antiretroviral therapy (ART) in persons living with human immunodeficiency virus (PLWHIV) is associated with disturbances in blood lipids which should be monitored. More data on such disturbances are needed in Cameroon to persuade the country program to institute their routine monitoring. We then sought to determine the prevalence and timing of dyslipidaemia in PLWHIV and receiving ART in a predominantly rural Cameroonian setting.MethodsA cross-sectional study conducted between August and October 2012 in HIV-infected persons aged 15 years or more and receiving first-line ART for at least six months at The Nkongsamba Regional Hospital in Cameroon. Lipid assays were carried out by enzymatic-linked colorimetric methods. A multiple logistic regression model was used to assess for factors related to dyslipidaemia.ResultsIncluded were 114 participants of whom 83 (72.8%) were females. Their median age was 43 years (IQR: 36–51) and their median CD4 count was 436 cells/μl (IQR: 275–585) after a median duration on ART of 36 months (IQR: 12–60). The prevalence of dyslipidaemia was 70.2%. Hypercholesterolaemia was observed in 34 (29.8%) patients. One-third of them had a high LDL-cholesterol level (LDL-c ≥ 130 mg/dl). Hypertriglyceridaemia (TG ≥ 150 mg/dl) was present in 59 (51.8%) cases. The proportion of patients with a low HDL-cholesterol (HDL-c < 40 mg/dl) was 18.4% while those with a ratio of TC/HDL-c ≥ 5 were about 16.7%. A duration of 2–4 years on ART (adjusted Odd Ratio, aOR = 5.22, 95% CI: 1.43-19.06, p = 0.01), current smokers (aOR = 15.94, 95% CI: 1.13-225.61, p = 0.04) and a concurrent metabolic disease (aOR = 12.54, 95% CI: 1.02-153.86, p = 0.48) were independently associated with pro-atherogenic LDL-c values. Alcohol users had a more friendly LDL-c profile (aOR = 0.24, 95% CI: 0.07-0.74, p = 0.01).ConclusionThe study has demonstrated a high prevalence of dyslipidaemia in HIV-patients receiving first-line ART in a predominantly rural setting of Cameroon. There is a need for the country HIV program to institute laboratory monitoring of blood lipids in patients over two years on first line ART with a focus on smokers.

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Section: Discussionmentioning

confidence: 99%

The lipid profile of HIV-infected patients receiving antiretroviral therapy in a rural Cameroonian population

Bekolo¹,

Nguena²,

Ewane

et al. 2014

BMC Public Health

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“…21 In a sample of Polish men, moderate drinkers (15-30 g per day) had a 35% lower risk of diabetes than light drinkers (≤15 g per day). 142 In a meta-analysis, the observed incidence of diabetes was reduced by low alcohol consumption, but increased in binge drinking. 153 Lipids Systematic reviews [10][11][12]29 and meta-analyses 89,105 of the effects of low-dose alcohol consumption on biological markers associated with CHD risk have shown a doseresponse relationship across beverage types, increasing levels of HDL cholesterol, apolipoprotein A-I, and adiponectin, and decreasing levels of LDL cholesterol.…”

Section: Alcohol and Cardiovascular Risk Factorsmentioning

confidence: 98%

“…89,105,108,157,158 Moderate alcohol intake increases the risk of hypertriglyceridaemia by 25% and hyperhomocysteinaemia by 46%. 142 The pattern of alcohol drinking influences BMI, and can cause obesity. 159,160 The results of a randomized feeding trial 127 involving beer, non alcoholic beer, and gin demonstrated that moderate alcohol consumption (30 g per day) increases serum HDL cholesterol by 5%, apolipoprotein A-I by 6%, and apolipoprotein A-II and adiponectin by 7%, providing indirect pathophysiological evidence supporting a 25-35% protective effect of moderate alcohol use on CHD in both women and men.…”

Section: Alcohol and Cardiovascular Risk Factorsmentioning

confidence: 99%

Cardiovascular risks and benefits of moderate and heavy alcohol consumption

2015

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The heart and vascular system are susceptible to the harmful effects of alcohol. Alcohol is an active toxin that undergoes widespread diffusion throughout the body, causing multiple synchronous and synergistic effects. Alcohol consumption decreases myocardial contractility and induces arrhythmias and dilated cardiomyopathy, resulting in progressive cardiovascular dysfunction and structural damage. Alcohol, whether at binge doses or a high cumulative lifetime consumption-both of which should be discouraged-is clearly deleterious for the cardiovascular system, increasing the incidence of total and cardiovascular mortality, coronary and peripheral artery disease, heart failure, stroke, hypertension, dyslipidaemia, and diabetes mellitus. However, epidemiological, case-control studies and meta-analyses have shown a U-type bimodal relationship so that low-to-moderate alcohol consumption (particularly of wine or beer) is associated with a decrease in cardiovascular events and mortality, compared with abstention. Potential confounding influences-alcohol-dose quantification, tobacco use, diet, exercise, lifestyle, cancer risk, accidents, and dependence-can affect the results of studies of both low-dose and high-dose alcohol consumption. Mendelian methodological approaches have led to doubts regarding the beneficial cardiovascular effects of alcohol, and the overall balance of beneficial and detrimental effects should be considered when making individual and population-wide recommendations, as reductions in alcohol consumption should provide overall health benefits.

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“…The general characteristics of the subjects included gender and age. Age was categorized as: under 30 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), 30s (30)(31)(32)(33)(34)(35)(36)(37)(38)(39), 40s (40)(41)(42)(43)(44)(45)(46)(47)(48)(49), 50s (50-59), or 60s (60-69).…”

Section: General Characteristics and Socioeconomic Statusmentioning

confidence: 99%

Sex Differences in Cardiovascular Disease Risk by Socioeconomic Status (SES) of Workers Using National Health Information Database

Ryu

Moon

Jung

2020

IJERPH

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The socioeconomic status (SES) and health behaviors of workers are associated with the risks of developing obesity, diabetes, hypertension, hyperlipidemia, and other cardiovascular diseases. Herein, we investigated the factors influencing cardiovascular disease (CVD) risk based on the SES of male and female workers. This cross-sectional analysis used the National Health Information Database to assess the associations between gender, SES (income level, residential area), health behaviors, and CVD-related health status of workers, through multinomial logistic regression. Upon analysis of a large volume of data on workers during 2016, the smoking and drinking trends of male and female workers were found to differ, causing different odds ratio (OR) tendencies of the CVD risk. Also, while for male workers, higher ORs of obesity or abdominal obesity were associated with higher incomes or residence in metropolitan cities, for female workers, they were associated with lower incomes or residence in rural areas. Additionally, among the factors influencing CVD risk, lower income and residence in rural areas were associated with higher CVD risk for male and female workers. The study findings imply the importance of developing gender-customized intervention programs to prevent CVD, due to gender-specific associations between CVD-related health status and health behaviors according to SES. Health Information Database (NHIS-NHID), was employed to verify the association between the SES of male and female workers in Korea and their CVD-related health statuses. The findings of this study will contribute to the production of basic statistics with large volumes of data through an analysis of the factors influencing CVD risk in male and female workers. Materials and Methods Data SourcesThe NHIS of Korea provides health insurance cover to the entire population of the country [13] and allows an insured worker and his or her dependent to receive a free annual or biannual health examination [15]. Based on the NHIS, the national health information database has a large volume of data, including 1.3 trillion pieces of information on the qualifications, premiums, health examination results, and treatment records of the entire population [16]. The NHIS-NHID is the dataset prepared by extracting, summarizing, and processing the health insurance information collected, possessed, and managed by the NHIS for study purposes, while ensuring that personal information cannot be identified [16]. The NHIS-NHID consists of the qualification database, the health examination database, and the claim database [15]. The qualification database includes gender differentiated into male and female, age, premium, and residential area. The premium is defined as the amount paid thus far by the insured worker, and it is categorized into one of 20 quintiles. The residential area is categorized into codes representing the area of residence of the insured. The health examination database contains data from a regular health examination and the accompanying health questi...

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Alcohol intake and cardiovascular risk factor profile in men participating in the WOBASZ study

Cited by 30 publications

References 28 publications

The lipid profile of HIV-infected patients receiving antiretroviral therapy in a rural Cameroonian population

The lipid profile of HIV-infected patients receiving antiretroviral therapy in a rural Cameroonian population

Cardiovascular risks and benefits of moderate and heavy alcohol consumption

Sex Differences in Cardiovascular Disease Risk by Socioeconomic Status (SES) of Workers Using National Health Information Database

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