Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness

Lin, Hui‐Yi; Wang, Xinnan; Tseng, Tung-Sung; Kao, Yu-Hsiang; Fang, Zhide; Molina, Patricia E.; Cheng, Chia-Ho; Berglund, Anders; Eeles, Rosalind; Muir, Kenneth; Pashayan, Nora; Haiman, Christopher A.; Brenner, Hermann; Park, Jong Y.

doi:10.3390/jcm10030553

Cited by 4 publications

(4 citation statements)

References 72 publications

(47 reference statements)

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“…The authors of this manuscript concluded: "Reducing alcohol consumption could slow prostate cancer disease progression." Another study of 3306 PCa patients with European ancestry from the PCa Consortium aimed to examine alcohol intake and SNPs in the four pathways associated with PCa aggressiveness (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) [131]. Investigators found that excessive alcohol intake significantly impacts PCa aggressiveness within the following genetic subgroups: CAMK2D (calcium/calmodulin-dependent protein kinase II delta, enriched in the cell cycle and the calcium signaling pathway), PRKCA (protein kinase C alpha, the modulator of cell adhesion and transformation), and ROBO1 (roundabout guidance receptor 1, cell migration factor and a tumor suppressor gene).…”

Section: The Impact Of Alcohol On the Aggressiveness Of Prostate Tumo...mentioning

confidence: 99%

“…In addition, the authors observed an additional moderate link between alcohol and SNPs of genes associated with PCa aggressiveness. These are HGF (hepatocyte growth factor), PDGFB (platelet-derived growth factor subunit B), SYK (spleen-associated tyrosine kinase), PDGFD (platelet-derived growth factor D), and COL4A3 (collagen type IV alpha 3 chain) [131].…”

Section: The Impact Of Alcohol On the Aggressiveness Of Prostate Tumo...mentioning

confidence: 99%

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Alcohol and Prostate Cancer: Time to Draw Conclusions

Macke

Petrosyan

2022

Biomolecules

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It has been a long-standing debate in the research and medical societies whether alcohol consumption is linked to the risk of prostate cancer (PCa). Many comprehensive studies from different geographical areas and nationalities have shown that moderate and heavy drinking is positively correlated with the development of PCa. Nevertheless, some observations could not confirm that such a correlation exists; some even suggest that wine consumption could prevent or slow prostate tumor growth. Here, we have rigorously analyzed the evidence both for and against the role of alcohol in PCa development. We found that many of the epidemiological studies did not consider other, potentially critical, factors, including diet (especially, low intake of fish, vegetables and linoleic acid, and excessive use of red meat), smoking, family history of PCa, low physical activity, history of high sexual activities especially with early age of first intercourse, and sexually transmitted infections. In addition, discrepancies between observations come from selectivity criteria for control groups, questionnaires about the type and dosage of alcohol, and misreported alcohol consumption. The lifetime history of alcohol consumption is critical given that a prostate tumor is typically slow-growing; however, many epidemiological observations that show no association monitored only current or relatively recent drinking status. Nevertheless, the overall conclusion is that high alcohol intake, especially binge drinking, is associated with increased risk for PCa, and this effect is not limited to any type of beverage. Alcohol consumption is also directly linked to PCa lethality as it may accelerate the growth of prostate tumors and significantly shorten the time for the progression to metastatic PCa. Thus, we recommend immediately quitting alcohol for patients diagnosed with PCa. We discuss the features of alcohol metabolism in the prostate tissue and the damaging effect of ethanol metabolites on intracellular organization and trafficking. In addition, we review the impact of alcohol consumption on prostate-specific antigen level and the risk for benign prostatic hyperplasia. Lastly, we highlight the known mechanisms of alcohol interference in prostate carcinogenesis and the possible side effects of alcohol during androgen deprivation therapy.

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Section: The Impact Of Alcohol On the Aggressiveness Of Prostate Tumo...mentioning

confidence: 99%

Section: The Impact Of Alcohol On the Aggressiveness Of Prostate Tumo...mentioning

confidence: 99%

Alcohol and Prostate Cancer: Time to Draw Conclusions

Macke

Petrosyan

2022

Biomolecules

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“…Studies have shown that alcohol consumption is linked to many diseases, including alcohol dependence, cardiovascular and cerebrovascular diseases, digestive system diseases, and [7]. For example, SNPs on the CAMK2D, ROBO1, and PRKCA genes, may increase an individual's vulnerability to excessive alcohol intake and the development of aggressive prostate cancer [8]. And the GA and AA genotypes on rs671 were associated with a lower risk of gout in Asians [9].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have also shown that genetic variations can alter the effect of alcohol intake on the aggressiveness of a range of tumors, such as prostate cancer, colon cancer [ 7 ]. For example, SNPs on the CAMK2D, ROBO1, and PRKCA genes, may increase an individual’s vulnerability to excessive alcohol intake and the development of aggressive prostate cancer [ 8 ]. And the GA and AA genotypes on rs671 were associated with a lower risk of gout in Asians [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic correlation for alcohol consumption between Europeans and East Asians

Liu,

2023

BMC Genomics

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Genome-wide association studies (GWAS) have identified many genetic variants associated with alcohol consumption in Europeans and East Asians, as well as other populations. However, the genetic homogeneity and heterogeneity between these populations have not been thoroughly investigated, despite evidence of varying effect sizes of variants between ethnicities and the presence of population-specific strong signals of selection on loci associated with alcohol consumption. In order to better understand the relationship between Europeans and East Asians in the genetic architecture of alcohol consumption, we compared their heritability and evaluated their genetic correlation using GWAS results from UK Biobank (UKB) and Biobank Japan (BBJ). We found that these two populations have low genetic correlation due to the large difference on chromosome 12. After excluding this chromosome, the genetic correlation was moderately high ($${r}_{g}$$ = 0.544, p = 1.12e-4) and 44.31% of the genome-wide causal variants were inferred to be shared between Europeans and East Asians. Given those observations, we conducted a meta-analysis on UKB and BBJ and identified new signals, including the CADM2 gene on chromosome 3, which has been associated with various behavioral and metabolic traits. Overall, our findings suggest that the genetic architecture of alcohol consumption is largely shared between Europeans and East Asians, but there are exceptions such as the enrichment of heritability on chromosome 12 in East Asians.

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Understanding and Addressing Prostate Cancer Disparities in Diagnosis, Treatment, and Outcomes Among Black Men

Murphy,

Cottrell-Daniels,

Awasthi

et al. 2024

Cancer Control

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Despite advances in screening, diagnosis, and treatment for prostate cancer (PCa), Black men tend to be diagnosed at younger ages, have higher mortality rates, and are at increased risk of recurrence or metastasis compared to their White counterparts. PCa disparities among Black men are caused by a complex interaction of social, behavioral, and biological factors across the public policy, community, organizational, interpersonal, and individual levels. Key contributing factors include mistrust in the health care system, poor communication between patients and providers, low awareness of screening guidelines, and high medical costs. These disparities are further exacerbated by the low representation of Black men in clinical trials, which limits access to high-quality cancer care and generalizability for PCa treatments. In this narrative review of the existing literature, we examined the epidemiology and identified contributing factors, and propose multi-level strategies to address and mitigate disparities among Black men with PCa.

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Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness

Cited by 4 publications

References 72 publications

Alcohol and Prostate Cancer: Time to Draw Conclusions

Alcohol and Prostate Cancer: Time to Draw Conclusions

Genetic correlation for alcohol consumption between Europeans and East Asians

Understanding and Addressing Prostate Cancer Disparities in Diagnosis, Treatment, and Outcomes Among Black Men

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