Alcohol injection: a new method of treating placental chorioangiomas

Nicolini, Umberto; Zuliani, G.; Caravelli, Elena; Fogliani, Roberto; Poblete, Andrés; Roberts, Alistair

doi:10.1016/s0140-6736(99)00781-3

Cited by 80 publications

(43 citation statements)

References 3 publications

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“…Due to the risk of thrombosis within the tumor and disruption of the arteriovenous shunts, suture ligation and thermocoagulation of the vascular network have been reported as treatment options [13]. Furthermore, 2 cases have been successfully treated with alcohol injection, similar to our first report of this technique in an acardiac fetus [14,15]. Despite these treatment modalities, the parents of our case refused any intervention on this extremely premature fetus as well as preterm delivery.…”

Section: Discussionmentioning

confidence: 66%

Large Placental Chorioangioma as a Cause of Sudden Intrauterine Fetal Death

et al. 2001

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A giant placental chorioangioma was diagnosed in a fetus at 22 weeks of gestation by prenatal ultrasound screening and color Doppler imaging. Although no signs of fetal hydrops and cardiac decompensation were observed, the situation of the fetus deteriorated rapidly and in utero fetal death occurred at 26 weeks, attributed to bleeding from ruptured sinusoids within the tumor. Prenatal diagnosis of chorioangioma and treatment modalities are discussed.

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Section: Discussionmentioning

confidence: 66%

Large Placental Chorioangioma as a Cause of Sudden Intrauterine Fetal Death

et al. 2001

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“…Several other techniques, in addition to those we employed, have also been described in the literature with varying success and limitations. Single or repeated injection of absolute ethanol into the feeding vessel or directly into tumor has been reported with resulting tumor regression and/or reversal of physiologic derangement [9,13,14,15]. This method does suffer from the hypothetical risk of perivascular tissue toxicity and potential fetal exposure [4].…”

Section: Discussionmentioning

confidence: 99%

Giant Chorioangiomas: Perinatal Outcomes and Techniques in Fetoscopic Devascularization

Lim¹,

Coleman²,

Polzin³

et al. 2014

Fetal Diagn Ther

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Objective: To evaluate the intrauterine management and perinatal outcome of pregnancies complicated by giant placental chorioangioma (>4 cm) and elaborate on various devascularization techniques. Materials and Methods: Retrospective review of 10 cases of giant placental chorioangioma evaluated between January 2005 and August 2012. Maternal demographics, prenatal imaging, response to fetoscopic treatment, obstetrical complications, and perinatal outcomes were evaluated. Results: Overall survival was 80%. Seven (70%) cases were associated with obstetrical complications, including polyhydramnios (n = 7), non-immune hydrops (n = 3), and high cardiac output state (n = 5). Five patients underwent fetoscopic devascularization at a mean gestational age of 24.03 weeks with 80% survival. The tumors were devascularized by bipolar coagulation (n = 1), combination of bipolar and diode laser (n = 2), bipolar and radiofrequency ablation (n = 1), and surgical clip application (n = 1). Postoperatively, all survivors had resolution of hydrops and high cardiac output states with survival beyond 60 days of life. Discussion: Fetoscopic devascularization is indicated for high cardiac output states or non-immune hydrops and may require multiple techniques including bipolar coagulation, clip application, and/or laser to interrupt arterial inflow and devascularize the mass.

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“…It may offer additional information to the clinician, guiding the management of such cases. [18][19][20] In our case, diagnosis was clinched on USG findings itself.…”

Section: Diagnosismentioning

confidence: 71%