Alcohol-Induced Pain Due to Carcinoma

James, Alison; Harley, H. R. S.; Horton, E.H.; Störring, F. K.

doi:10.1016/s0140-6736(57)90361-6

Cited by 18 publications

(3 citation statements)

References 4 publications

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“…It was subsequently described in a number of different carcinomata (James et al, 1957;Braun and Shnider, 1958;Healy, 1959;Wanka, 1965) in several non-malignant conditions, particularly )f bone (Alexander, 1953;Joske, 1955;Conn, 1957;Braun and Shnider, 1958;Lewes and Valentine, 1962), and in apparently normal persons (Conn, 1957;Snell, 1966).…”

Section: Commentmentioning

confidence: 98%

“…The pain often occurs in the absence of bone destruction (James et al, 1957) and the lack of previous reports of this association with chordoma, where bone destruction is so prominent, argues against this as the prime factor. I would like to thank Dr. M. Kremer and Professor V. Logue for permission to report details of a case under their care and for their comments.…”

Section: Commentmentioning

confidence: 99%

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Alcohol-induced pain in chordoma.

Perkin¹

1973

BMJ

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Since its first description in Hodgkin's disease, alcohol-induced pain has subsequently been described both in other neoplasms and in various non-malignant conditions. It does not appear to have been described in any intracranial lesion, including chordoma. It was a presenting symptom in our patient with an intracranial chordoma.Case Report A 34-year-old Egyptian was admitted to hospital on 8 February 1973. One year previously he began to develop a severe occipital pain about 10 minutes after ingestion of any type of alcohol, lasting up to two hours. Four months later he developed constant occipital and nuchal pain, exacerbated by alcohol and by straining. Six months before admission he developed ataxia, followed by dysphagia for solids and liquids, then left facial numbness. His condition deteriorated greatly in the week before admission.On examination he was generally unwell. The skull and cervical spine were normal. The cranial nerves showed normal fundi, bilateral ptosis, left sixth nerve weakness, coarse horizontal nystagmus on right lateral gaze, impaired facial sensation on the left, bilateral peripheral facial weakness-more noticeable on the left, minimal palatal movement with deviation to the right, and a bilaterally wasted tongue with deviation to the right.The sternomastoids were atrophic but not definitely weak. He showed mild limb ataxia-more pronounced on the left, the abdominal reflexes were absent, and the left plantar response was extensor. There was considerable gait ataxia.Examination of the postnasal space under anaesthesia showed nothing abnormal. Vertebral angiography (see Fig.) showed a large prepontine mass.His condition deteriorated after admission and he required tracheostomy. Craniotomy was performed on 16 February. A chordoma, confirmed histologically, was found extending from just within the foramen magnum to 1 cm short of the civus superiorly. The ninth, tenth, and eleventh cranial nerves were tightly applied to the right hand margin of the tumour. The twelfth cranial nerve could not be identified. An extensive resection was performed but residual infiltration of the retropharyngeal space remained. His postoperative course was uneventful.Though the sixth nerve weakness and tongue weakness remained, facial numbness -disappeared, while facial and palatal movements improved. Postoperative deep x-ray therapy was carried out.Three weeks after surgery the patient was given 15 ml of brandy in orange juice-this failed to produce any pain. CommentApart from the presence of alcohol-induced pain, the presentation of this patient's tumour was similar to those cases of clivus

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Section: Commentmentioning

confidence: 98%

Section: Commentmentioning

confidence: 99%

Alcohol-induced pain in chordoma.

Perkin¹

1973

BMJ

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“…The pain is usually se· vere and localized to one or more groups of lymph nodes. It may last for only a few minutes or for several hours and may re· quire morphine for relief Although alcohol-induced pain is com· monly associated with Hodgkin's disease, it also has been reported to occur in carcinomas of the thymus and pancreas, osteomyeli- tis, bone fractures, and pyogenic lymphadenitis (2)(3)(4). The purpose of this report is to describe the first instance of alcoholinduced pain in a patient with sarcoidosis.…”

Section: Introductionmentioning

confidence: 98%