Alcohol-induced hypogonadism: Reversal after ethanol withdrawal

Castilla-Garcia, A.; Santolaria-Fernández, Francisco; González-Reimers, C.E.; Batista-López, Norberto; González-Garcı́a, Cándido; Jorge-Hernández, J.A.; Hernández-Nieto, L

doi:10.1016/0376-8716(87)90035-4

Cited by 34 publications

(12 citation statements)

References 12 publications

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“…Altogether, these data partly confirm previous studies which demonstrated a reversal of alcohol‐induced hypogonadism after ethanol withdrawal (Castilla‐Garcia et al . 1987; Ruusa, Bergman & Sundell 1997).…”

Section: Discussionsupporting

confidence: 91%

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CLINICAL STUDY: Endocrine alterations during a detoxification treatment with carbamazepine in male alcoholics

Krüger

Goebel²,

Schiffer³

et al. 2006

Addiction Biology

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This study aimed to evaluate the prevalence and time-course of endocrine alterations in male alcohol addicts during a detoxification treatment and to examine a possible relation between endocrine alterations and depressive symptoms and overall mental distress. Blood samples were drawn in 54 male alcohol addicts on admission, at day 7 of treatment and at day 14 on discharge. Endocrine analysis was performed for cortisol, luteinizing hormone, prolactin, androgens, free testosterone and 17beta-estradiol. Psychometric measures (Beck's depression inventory and the symptom checklist-90-R) were taken on admission and on discharge and were correlated with endocrine measures. Cortisol plasma levels were substantially increased at the beginning of the detoxification, whereas all other endocrine parameters were within the normal range. Although subjects depicted mild to moderate levels of depressive symptoms and mental distress, there were no correlations with endocrine variables. Further analysis revealed a high variation in sex steroid levels with approximately 55% of participants showing initial (n = 19) or developing (n = 11) hypogonadal values during detoxification. In conclusion, chronic alcohol consumption induces disturbances of gonadal function which are reversible in the majority of cases. However, few patients develop a hypogonadal state during detoxification. Initially increased cortisol levels indicate a bodily stress response with the onset of alcohol withdrawal but are not related to mental disturbances.

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Section: Discussionsupporting

confidence: 91%

“…However, in parallel to Ruusa et al . (1997) the current data did not show compensatory elevated LH levels, which had been demonstrated by others (Castilla‐Garcia et al . 1987).…”

Section: Discussionsupporting

confidence: 82%

CLINICAL STUDY: Endocrine alterations during a detoxification treatment with carbamazepine in male alcoholics

Krüger

Goebel²,

Schiffer³

et al. 2006

Addiction Biology

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show abstract

“…They increase progressively during a period of abstinence. 42,43 The inverse time-dependent change of serum leptin levels 12,16 fits very well to our hypothesis that androgens affect craving of men in alcohol withdrawal by modulation of leptin.…”

supporting

confidence: 77%

The modulating effect of the androgen receptor on craving in alcohol withdrawal of men is partially mediated by leptin

et al. 2009

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We reported recently that a functional relevant CAG trinucleotide repeat of the androgen receptor influences craving of men in alcohol withdrawal. It is known to modulate serum concentrations of leptin, which affects hypothalamic appetite regulation. Its plasma levels are elevated during chronic alcohol consumption, normalize within periods of abstinence and are associated with craving. The aim of this study was to further elucidate the role of leptin in mediating the effects of the mentioned polymorphism on craving in men undergoing alcohol withdrawal. We included 110 male in-patients who were admitted for detoxification treatment. Each one had an established diagnosis of alcohol dependence according to the DSM-IV. Our results show on the one hand negative associations between the number of CAG repeats and (i) leptin serum levels (Po0.01) and (ii) craving (Po0.05), and on the other hand, a positive association between leptin and craving of man in alcohol withdrawal (Po0.001). The path analysis revealed direct and mediated effects of the number of CAG repeats on alcohol craving, direct effects (r ¼ À0.144) accounting for 60% and indirect, leptin-mediated effects (r ¼ À0.096) accounting for 40% of the total effect. Dysregulation of sexual hormones influences human metabolism and seems to affect leptin homeostasis. This report suggests that the investigated polymorphism mediates its effect on craving of men in alcohol withdrawal mostly through the regulation of leptin. Nevertheless future studies are needed to further explore the functionality of the androgen receptor gene in terms of craving.

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“…For roughly 40 years, evidence suggests that alcohol affects sex hormones (Galvao-Teles et al 1973). Sexual disturbances are a common medical consequence of alcohol abuse and are associated with dysregulation of sexual hormones including testosterone (Castilla-Garcia et al 1987). As shown in Figure 2, the hypothalamus produces gonadotropin-releasing hormone (GnRH), also known as Luteinizing-hormone-releasing hormone (LHRH) and luliberin.…”

Section: Reproductive Hormonesmentioning

confidence: 99%

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

et al. 2012

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Alcohol-induced hypogonadism: Reversal after ethanol withdrawal

Cited by 34 publications

References 12 publications

CLINICAL STUDY: Endocrine alterations during a detoxification treatment with carbamazepine in male alcoholics

CLINICAL STUDY: Endocrine alterations during a detoxification treatment with carbamazepine in male alcoholics

The modulating effect of the androgen receptor on craving in alcohol withdrawal of men is partially mediated by leptin

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

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