Alcohol impairment of behavior in men and women

Fillmore, Mark T.; Weafer, Jessica

doi:10.1111/j.1360-0443.2004.00805.x

Cited by 129 publications

(112 citation statements)

References 38 publications

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“…Much of the research literature has focused on behavioral inhibition following alcohol consumption (Fillmore & Weafer, 2004), but we were unable to find studies that specifically examined response inhibition and alcohol problems. At first, the results reported in Figure 1 seem paradoxical and they do not support our initial hypothesis that higher levels of impulsivity would be associated with greater risk for health-risk behaviors.…”

Section: Discussionmentioning

confidence: 99%

Does gender moderate associations among impulsivity and health-risk behaviors?

Stoltenberg

Batien

Birgenheir

2008

Addictive Behaviors

116

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The present study explores the relations among gender, impulsivity and three health-risk behaviors relevant to young adults (tobacco use, alcohol problems and gambling problems) in a sample of 197 college-age individuals. We sought to determine whether impulsivity is associated with health-risk behaviors in the same ways for men and women. For tobacco use and gambling problems, men were at higher risk than women, and impulsivity was not significantly associated with higher risk. Higher levels of motor impulsivity in men accounted for a significant amount of the gender difference in risk for alcohol problems. That is, impulsivity as measured by the Barratt Impulsiveness Scale (version 11), mediated the association between gender and risk for alcohol problems. For impulsivity as measured by Stop Signal Reaction Time (i.e. response inhibition), gender moderated the association between impulsivity and alcohol problems. Specifically, lower levels of impulsivity were associated with greater risk for alcohol problems in both men and women, but the effect was stronger in men. We speculate that this seemingly paradoxical result might be the result of coping drinking to deal with negative affect associated with behavioral overcontrol. These findings suggest that prevention efforts might well focus on identifying individuals at high risk for alcohol problems, especially males, by assessing response inhibition.

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Section: Discussionmentioning

confidence: 99%

Does gender moderate associations among impulsivity and health-risk behaviors?

Stoltenberg

Batien

Birgenheir

2008

Addictive Behaviors

116

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“…That females exceed males in a number of drug-related behaviors is influenced by hormonal status (e.g., Carroll et al, 2004;; however, it may also be enhanced by elevated impulsivity, another major vulnerability factor, in females. Clinical studies of sex differences in impulsivity have reported mixed findings, that women have lower (Kirby and Marakovic, 1996), higher (Wallace, 1979), or the same (Fillmore and Weafer, 2004;Skinner et al, 2004) levels of impulsivity compared to males. In a preclinical experiment addressing the relationship between sex and impulsivity, Jentsch and Taylor (2003) used a Go/No-go task in which rats were trained to respond for a food pellet upon illumination of a stimulus light (the Go period).…”

Section: Introductionmentioning

confidence: 99%

Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake

Perry

Nelson

Anderson

et al. 2007

Pharmacology Biochemistry and Behavior

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Previous research in rats indicates that delay discounting for food, a model of impulsivity, predicted the rate of acquisition of cocaine self-administration. In other studies, rats bred for high saccharin intake (HiS) acquired cocaine self-administration at higher rates than those with low saccharin intake (LoS), and female (F) rats acquired cocaine self-administration more rapidly than males (M). The purpose of this study was to examine a possible connection between impulsivity, saccharin intake, and sex by comparing M and F rats from the HiS and LoS selectively bred lines on measures of impulsivity; i.e., their rate of delay discounting for food or i.v. cocaine infusions. The adjusting delay procedure allowed rats access to 2 response levers, and a pellet dispenser or an i.v. drug infusion pump. In 4 groups (HiS M, HiS F, LoS M, LoS F) responses under a fixed-ratio (FR) 1 schedule on one lever resulted in one 45 mg pellet immediately, and responses on the other lever resulted in 3 or 6 pellets after a delay. Four additional groups received either a small cocaine (0.2, 0.4, or 0.8 mg/kg) infusion immediately or a delayed larger infusion (3 × the amount of the small infusions). The delay to the larger reinforcer began at 6 sec and increased or decreased by 1 s following responses on the delay or immediate levers, respectively. A mean adjusted delay (MAD) was calculated over 30 choice trials during each daily 3-hr session, and it was used as a quantitative measure of impulsivity. In groups maintained by food, HiS rats were more impulsive (lower MADs) than LoS rats, and LoS females were more impulsive than LoS males. There were no phenotype or sex differences in delay discounting for cocaine. Understanding the relationship between impulsivity and other predictors of drug abuse (e.g., sex, saccharin intake) is important in developing prevention and treatment strategies.

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“…Another potential but understudied influence is sex/gender. Although evidence suggests that BrACs of 80 mg/dl or more might differentially affect men and women (Fillmore & Weafer, 2004;Miller et al, 2009), few investigations have considered sex when evaluating lower doses (for a review, see Nixon et al, 2014).…”

mentioning

confidence: 99%

Alcohol Doesn’t Always Compromise Cognitive Function: Exploring Moderate Doses in Young Adults

Hoffman

Nixon

2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: The purpose of this study was to clarify inconsistent findings regarding the acute cognitive effects of subintoxicating alcohol doses (i.e., <80 mg/dl) by controlling for and evaluating variables that might modulate dose-related outcomes. Method: The current study examined the effects of sex/gender and alcohol concentration on select cognitive functions in 94 individuals (49 men) between 25 and 35 years of age. Participants were randomly assigned to one of three dose conditions: target peak breath alcohol concentration of 0 mg/dl (placebo), 40 mg/dl (low), or 65 mg/dl (moderate). After beverage consumption, they completed tasks assessing psychomotor, set-shifting, and working memory ability. Results: Analyses revealed no significant effect of dose for any cognitive domain. A trend-level effect of dose on psychomotor performance was observed, with the low-dose group performing somewhat better than the moderate-dose and placebo groups. No sex main effects or interactions were revealed. Conclusions: Consistent with our previous studies, these data suggest that low and moderate doses of alcohol may not compromise cognitive ability in non-problem drinkers under certain task conditions. Given the outcomes, sex differences cannot be meaningfully addressed. Future consideration of potentially influential variables and assessment of similarly well-defined cohorts might yield a clearer interpretation of alcohol's behavioral consequences. (J. Stud. Alcohol Drugs, 76, 952-956, 2015)

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Alcohol impairment of behavior in men and women

Cited by 129 publications

References 38 publications

Does gender moderate associations among impulsivity and health-risk behaviors?

Does gender moderate associations among impulsivity and health-risk behaviors?

Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake

Alcohol Doesn’t Always Compromise Cognitive Function: Exploring Moderate Doses in Young Adults

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