Alcohol-free synthesis, biological assessment, in vivo toxicological evaluation, and in silico analysis of novel silane quaternary ammonium compounds differing in structure and chain length as promising disinfectants

Tagorti, Ghada; Yalçın, Burçin; Güneş, Merve; Burgazlı, Ayşen Yağmur; Kuruca, Tuğçe; Cihanoğlu, Neslihan; Akarsu, Esin; Kaya, Nuray; Marcos, Ricard; Kaya, Bülent

doi:10.1016/j.jhazmat.2024.133470

Cited by 1 publication

(2 citation statements)

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“…The expression of related genes in rice seedlings, UGT79 encoding glycosyltransferase and AdK2 encoding adenosine kinase, were determined by quantitative real-time polymerase chain reaction (qRT-PCR) under different exposure times (0.5, 2, 10, and 24 h). The extraction and purification of total RNA referenced to previous research studies . RNA was reverse-transcribed into cDNA using the instructions of the Takara reverse transcription kit (Monad Biotech Co. Ltd., China).…”

Section: Methodsmentioning

confidence: 99%

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Uptake and Biotransformation of Guvermectin in Three Crops after In Vivo and In Vitro Exposure

Shi,

Pan,

et al. 2024

J. Agric. Food Chem.

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Guvermectin, as a novel nucleoside-like biopesticide, could increase the rice yield excellently, but the potential environmental behaviors remain unclear, which pose potential health risks. Therefore, the uptake and biotransformation of guvermectin in three types of crops (rice, lettuce, and carrot) were first evaluated with a hydroponic system. Guvermectin could be rapidly absorbed and reached equilibrium in roots (12−36 h) and shoots (24−60 h) in three plants, and guvermectin was also vulnerable to dissipation in roots (t 1/2 1.02−3.65 h) and shoots (t 1/2 9.30−17.91 h). In addition, 8 phase I and 2 phase II metabolites, transformed from guvermectin degradation in vivo and in vitro exposure, were identified, and one was confirmed as psicofuranine, which had antibacterial and antitumor properties; other metabolites were nucleoside-like chemicals. Molecular simulation and quantitative polymerase chain reaction further demonstrated that guvermectin was metabolized by the catabolism pathway of an endogenous nucleotide. Guvermectin had similar metabolites in three plants, but the biotransformation ability had a strong species dependence. In addition, all the metabolites exhibit neglectable toxicities (bioconcentration factor <2000 L/kg b.w., LC 50,rat > 5000 mg/kg b.w.) by prediction. The study provided valuable evidence for the application of guvermectin and a better understanding of the biological behavior of nucleoside-like pesticides.

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Section: Methodsmentioning

confidence: 99%

“…The extraction and purification of total RNA referenced to previous research studies. 35 RNA was reverse-transcribed into cDNA using the instructions of the Takara reverse transcription kit (Monad Biotech Co. Ltd., China). The primer pairs are described in Table S9.…”

Section: Instrument Conditions Of Uplc-ms/msmentioning

confidence: 99%

Uptake and Biotransformation of Guvermectin in Three Crops after In Vivo and In Vitro Exposure

Shi,

Pan,

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Alcohol-free synthesis, biological assessment, in vivo toxicological evaluation, and in silico analysis of novel silane quaternary ammonium compounds differing in structure and chain length as promising disinfectants

Cited by 1 publication

References 64 publications

Uptake and Biotransformation of Guvermectin in Three Crops after In Vivo and In Vitro Exposure

Uptake and Biotransformation of Guvermectin in Three Crops after In Vivo and In Vitro Exposure

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