Alcohol-Free Microemulsions

Abstract

Ternary and Pseudo-ternary phase behavior of the system water/hexadecane/dioctyl sodium sulfosuccinate (DSS)/sorbitan 1aurate has been determined.The mi croemuls i on regi on of thi s alcohol-free system has potential for use as a pharmaceutical topical vehicle.A 1/1 weight ratio of sorbitan laurate:DSS (60:40)/hexadecane can solubil ize up to 55% water, while sobitan 1aurate: DSS ratios larger than 70/30 show dramat i cally decreased water solubilization at equivalent hexadecane concentrations.

Physicochemical investigations of microemulsification of eucalyptus oil and water using mixed surfactants (AOT+Brij-35) and butanol

“…This indicated that the w/o system was converted to the o/w system through a bicontinuous state. Such a behavior was reported earlier for polyoxyethylene [10] oleyl alcohol (Brij-97)/butanol/dodecane/water [58]; SDS/propanol/cyclohexane/water [59]; and CTAB/1-propanol/cyclohexane/water [60] systems. O/w systems have been observed to have viscosity values higher than those of the w/o systems.…”

“…Owing to their diphilic nature, surfactants distribute their head and tail parts to the corresponding pothe system; (iii) reduce interfacial tension; (iv) increase the fluidity of the interface and thereby increasing the entropy of the system; (v) increase the mobility of the hydrocarbon tail and allow greater penetration of the oil into this region; and (vi) influence the solubility properties of the aqueous and oleic phases due to its partitioning between the phases. Several attempts to substitute traditional cosurfactants with other components [9][10][11][12][13][14], for example, nonionic surfactants, alkanoic acids, alkanediols, amines, aldehydes, ketones, butyl lactate, and oleic acid, have been carried out from the viewpoint of suitable applications of microemulsions. The roles of cosolvents and additives in the preparation of microemulsions are also reported [15][16][17].…”

Microemulsion-based Drug Delivery System for Enhancement of Absorption Efficiency of Levofloxacin Hemihydrate

“…It should be noted that the area of microemulsion region is considerably large since 1-propanol acts as a co-surfactant and interacts with the surfactant monolayer to increase the flexibility of the interfacial film. Microemulsions are formed spontaneously when their components come together [12]. The order of mixing of various components is not expected to influence the formation of microemulsions if the system is indeed thermodynamically stable.…”

Self-Emulsifying Formulation of Indomethacin with Improved Dissolution and Oral Absorption

“…There was no phase separation or precipitation which indicates the non ionic surfactants used were stable to change in pH and the concentration of electrolyte. 46 This is necessary for stable emulsion system as it gets in contact with various physiological fluids in the system. …”